Neuro-norms

Neuro-norms is a complex medical agent with a strong nootropic effect.

[1], [2], [3], [4], [5], [6],

Indications Neuro-norm

It is used for cerebral diseases of a chronic or acute nature (among them encephalopathy and ischemic form of stroke), and at the same time after hemorrhagic type of stroke and in the case of comatose and subcomatose states in patients with cerebral trauma or poisoning.

The drug is used for the prevention and treatment of the effects of TBI, Meniere's disease or migraines and disorders in the vestibular apparatus, against the background of which there is ear noise, nausea, nystagmus, and in addition dizziness.

It is prescribed for complex treatment of infections and inflammations affecting the central nervous system.

Neuro-norms are used in children with intellectual retardation to increase the ability to memorize and learn, and at the same time in people with psychogenic etiology of asthenic syndrome, which develops strong irritability, anxiety and emotional instability, and at the same time memory deteriorates with attention.

The drug should be used in persons in whom the use of piracetam in monotherapy causes increased excitability and insomnia.

[7], [8]

Release form

The release of therapeutic agent is made in capsules, inside the cell plates, in the amount of 10 pieces. Inside the box - 1, 2 or 6 such records.

[9]

Pharmacodynamics

Neuro-norms helps stabilize the microcirculation, improving the rheological blood characteristics and providing anti-vasoconstrictor effect. The active elements of drugs - piracetam with cinnarizine - have complementary properties.

Piracetam is a cyclic derivative of the GABA component. It helps improve memory and learning ability, as well as concentration. Along with this stimulates the processes of mental performance.

The substance regulates the speed of movement of excitatory cerebral impulses, stimulates metabolic processes in the area of nerve tissues and helps to improve synaptic transport within neocortical structures and synthesis between the cerebral hemispheres. Also piracetam, affecting the rheological blood parameters, piracetam improves microcirculation, without a strong vasodilator effect.

Cinnarizine is an element that helps improve microcirculation inside the cerebral vessels. The principle of influence of the component is based on the ability to block the Ca channels and the ability to enhance the stability of the vascular membranes in relation to vasoconstrictor agents (among them serotonin with norepinephrine).

Cinnarizine helps to improve microcirculation, but does not lead to changes in blood pressure values and heart rate indicators. In addition, long-term administration of cinnarizine increases the elasticity of the erythrocyte walls and reduces blood viscosity, which improves brain function and microcirculation processes.

The substance, used for a long time, helps to improve the state of brain cells during hypoxia and reduces the stimulation of the vestibular apparatus.

Drug administration to people with cerebral disorders leads to improved cognitive abilities and concentration.

The drug eliminates the dizziness that appears in connection with hypoxia and increased excitation of the vestibular apparatus.

[10], [11], [12], [13], [14], [15]

Pharmacokinetics

When the substance is ingested, the values of plasma Cmax of pyracetam with cinnarizine are noted after 1-4 hours. A noticeable drug effect is recorded after 1-6 hours.

Active elements of drugs have the ability to pass through the BBB. Cinnarizine almost fully undergoes metabolic processes, and piracetam is excreted unchanged.

The half-life of cinnarizine is 3-6 hours, and piracetam is 4-6 hours. Excretion of piracetam is mainly through the intestines, and cinnarizine and about 30% of piracetam are excreted through the kidneys.

[16], [17], [18], [19],

Dosing and administration

The medication is used for ingestion; need to use capsules after eating food. Chew medication is not necessary. The sizes of portions and the duration of the course are selected by the attending doctor, who takes into account the personal characteristics of the patient.

Adults often take 1 capsule of drugs 3 times a day.

In the case of motor pathologies, you need to use 1 capsule of the medication half an hour before going for a walk. The repetition of the reception should be carried out at 6-hour intervals.

Children generally take 1 capsule 2 times a day.

It is forbidden to use the medicine for more than 3 months in a row. When needed, it is used in 3-month courses, repeating them 2-3 times a year.

[26], [27], [28], [29]

Use Neuro-norm during pregnancy

Neuro-norms can not be used during pregnancy.

If the medicine must be used during breastfeeding, it is necessary to consult with your doctor and discuss the issue of discontinuation of hepatitis B. At the end of the treatment cycle, it is allowed to resume breastfeeding (but first you should consult your doctor).

Contraindications

It is forbidden to use the drug in persons with hypersensitivity to cinnarizine, piracetam, and pyrolidone derivatives.

In addition, it is not prescribed for people with glucose-galactose malabsorption, galactosemia, and lactose intolerance.

The drug is not used in patients with severe disorders in the kidneys, parkinsonism, psychomotor agitation, acute disorders of cerebral blood flow and an increased level of IOP. Neuro-norms should not be taken by people with Huntington's syndrome.

Caution is used in patients with liver or kidney disease, hemostasis disorders, porphyria, and also before performing the planned surgical procedures.

It is forbidden to apply to athletes, because the existing elements of the drug can give a false positive response during the doping tests.

[20],

Side effects Neuro-norm

Among the side signs of medication:

• CNS and PNS lesions: ataxia, hyperkinesia, diurnal disturbances, problems with balance and motor coordination, intense headaches or parkinsonism with tremor and strong hallucinations, and in addition dyskinesia, anxiety and severe fatigue. Along with this, there may be a worsening of the condition in epileptics, the appearance of hypersomnia, feelings of severe confusion, lethargy and depression;
• disorders of the hepatobiliary structure and gastrointestinal tract: discomfort along with pain in the epigastric zone, diarrhea, nausea, digestive disorders, dryness of the oral mucosa, vomiting, cholestasis with jaundice and hypersalivation;
• allergy symptoms: anaphylactoid manifestations (anaphylaxis and angioedema), hyperhidrosis, urticaria, photosensitivity, lichen planus and dermatitis;
• other: changes in blood pressure, muscle rigidity, increased libido, thrombophlebitis, weight or temperature increase.

[21], [22], [23], [24], [25]

Overdose

The use of large doses of the drug can lead to potentiation of the intensity of the negative manifestations of its active elements. At the same time, acute neuro-norm poisoning can cause diarrhea (also mixed with blood in the faeces), drowsiness, extrapyramidal symptoms, pain in the epigastric zone, a decrease in blood pressure and vomiting.

In severe poisoning, a coma develops.

In children, intoxication causes the appearance of signs of strong arousal of the central nervous system, including tremor, insomnia, convulsions with euphoria and hallucinations.

The drug does not have an antidote. After less than 1 hour after the introduction of too large portions of the drug, perform gastric lavage and enterosorbents used. In addition, in case of overdose, symptomatic procedures are performed.

If the patient’s condition is severe, hemodialysis can be performed.

[30], [31],

Interactions with other drugs

When a drug is combined with drugs that suppress the work of the central nervous system, potentiation of its sedative properties is observed (among such drugs there are tricyclics, ethanol and sedatives).

The combined use leads to the potentiation of the medication effect of vasodilating, antihypertensive and nootropic drugs, and in addition to this used inside the anticoagulants.

The introduction of the drug, together with hormones that have a thyroid character, can provoke a feeling of anxiety or tremor.

The substance may cause changes in the testimony of epidermal tests.

[32], [33], [34], [35],

Storage conditions

Neuro-norms must be maintained at temperatures that are below 25 ° C.

[36], [37], [38], [39], [40]

Shelf life

Neuro-norms are allowed to apply for a 2-year period from the date of production of the medicinal component.

[41], [42], [43], [44]

Application for children

Do not prescribe medication for children under 5 years of age. The age group of 5-8 years old therapeutic substance can be used exclusively under medical supervision.

[45], [46], [47]

Analogs

Analogues of the medication are the substances Omaron with Fezam and Piracesin.

[48], [49],