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Neurovin
Last reviewed: 23.04.2024
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Neurovin is a psychostimulant with nootropic activity.
Indications Neurin
It is used in neurology - various types of cerebrovascular disease: conditions associated with the transmission of intracerebral blood flow disorders (stroke), vascular dementia, VBN, encephalopathy, which is hypertensive or post-traumatic, and cerebral-type atherosclerosis. The drug helps to weaken the neurological and mental manifestations of cerebrovascular disease.
May be prescribed for ophthalmologic procedures - in case of chronic disease of the eye retina and vessel lining.
It is also used in otorhinolaryngology, with perceptual presbyacusis, ear noise and Meniere's syndrome.
Release form
The release of the drug produced in tablets, in an amount of 10 pieces inside a cellular packaging, 3 packs inside a pack.
Pharmacodynamics
Vinpocetine is a compound with a combined type of influence that positively affects cerebral metabolic processes and improves the blood supply to the brain. In addition, the component improves rheological blood parameters.
Vinpocetine has neuroprotective activity: reduces the negative effects of cytotoxic symptoms that are provoked by stimulating amino acids. The drug slows down the activity of voltage-dependent N +/-, as well as Ca2 +/- channels, and with it the terminations of NMDA with AMPA. Also potentiates the neuroprotective activity of adenosine.
Neurovin stimulates the activity of cerebral metabolic processes: it increases glucose and O2 uptake, as well as the consumption of these components by the cerebral tissues. Increases resistance of the brain to hypoxia, increases the volume of glucose transported through the BBB - an important and exceptional energy source for the brain, moves the glucose metabolism to a more appropriate energetic aerobic pathway, selectively slows down the effect of the Ca2 +/- calmodulin dependent enzyme cGMP-PDE and increases the values of cAMP together with cGMP inside the brain.
Increases ATP values, and in addition, the ratio of ATP elements with AMP, potentiates the metabolism of serotonin with noradrenaline occurring inside the brain and stimulates the upward activity of the noradrenergic system. At the same time, it has an antioxidant effect and a cerebroprotective effect, which develops as a result of the action of all the above factors.
Vinpocetine helps to improve cerebral microcirculation: slows down platelet aggregation, reduces pathologically increased blood viscosity, increases red blood cell deformability, and also slows down the process of adenosine uptake. In addition, it improves the processes of O2 movement inside the tissues, weakening affinity B2 for red blood cells.
The drug selectively increases the cerebral circulation: it increases the cerebral fraction of the cardiac output and weakens the resistance of the blood vessels inside the brain, while not affecting the properties of the general circulation (cardiac output, OPS, blood pressure and pulse rate). At the same time, its use leads to an improvement in the passage of blood into the damaged (but not yet necrosis) ischemic zones with low perfusion.
Pharmacokinetics
Absorption.
Vinpocetine is absorbed at high speed, reaching plasma Cmax values after one hour after ingestion. Most of the element is absorbed through the proximal GI tract. The substance does not participate in metabolic processes when passing through the intestinal wall.
Distribution processes.
The highest rates of substance were observed inside the gastrointestinal tract and liver. The Cmax level inside the tissues is recorded after 2-4 hours from the moment of using the drug. The values of the radioactive label inside the brain correspond to blood counts.
Synthesis with blood protein is 66%. The values of bioavailability after internal use are equal to 7%. The rate of drug clearance (66.7 l / h) inside the blood plasma is higher than the hepatic values (50 l / h), from which it can be concluded that the metabolism of the component does not occur inside the liver.
Exchange processes.
The main metabolic element is the AVK substance, which is formed from 25-30% of the drug. When ingested, the AUC values for AVK are twice as high as those after IV injection, from which it is assumed that AVK is formed during the system-wide exchange of vinpocetine.
Excretion.
After repeated ingestion of 5 and 10 mg of the substance, linear therapeutic kinetics is noted. The half-life of the drug is 4.83 ± 1.29 hours. Most of the drug is excreted through the intestines and kidneys in the proportion of 40/60%.
Dosing and administration
Standardly, 5–10 mg of the drug is prescribed 3 times a day (15–30 mg per day). Pills should be taken after eating food.
The duration of the therapeutic cycle is selected by the attending doctor personally.
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Use Neurin during pregnancy
It is forbidden to prescribe Neurovin when breastfeeding or pregnancy.
Contraindications
It is contraindicated to use in case of strong intolerance of the active ingredient or auxiliary elements of the drug.
Side effects Neurin
Among the side effects:
- lesions of the lymph and blood system: thrombocyto-or leukopenia is rarely observed. Erythrocyte agglutination or anemia is singularly manifested;
- immune disorders: there is a single strong sensitivity;
- problems with nutritional and metabolic processes: sometimes hypercholesterolemia develops. Anorexia, anorexia and diabetes mellitus are rarely observed;
- mental disorders: occasionally sleep problems, insomnia, and anxiety. Unity develops depression or a feeling of euphoria;
- HCS lesions: occasionally headaches, dysgeusia, amnesia, dizziness, as well as drowsiness, hemiparesis, and stupor. Single cramps or tremors appear;
- disorders of the visual organs: occasionally there is swelling of the nipple in the optic nerve. Single - conjunctival hyperemia;
- Disorders associated with the labyrinth and auditory organs: sometimes vertigo occurs. Occasionally there is hypo-or hyperacusia, as well as ear noise;
- problems with the activity of the cardiovascular system: rarely there is tachycardia, myocardial infarction or ischemia, palpitations, bradycardia with extrasystole and IHD. A single atrial fibrillation or just an arrhythmia develops;
- violations associated with the work of blood vessels: sometimes increased values of blood pressure. Occasionally, hot flashes or thrombophlebitis appear and blood pressure decreases. Unity can develop fluctuations in blood pressure levels;
- damage to the gastrointestinal tract function: sometimes dryness of the oral mucosa, abdominal discomfort and nausea sometimes appear. Occasionally, dyspepsia, pain in the abdominal area, vomiting, and diarrhea occur. Single develops stomatitis or dysphagia;
- disorders affecting the subcutaneous layers and the epidermis: occasionally itching, erythema, rash, urticaria or hyperhidrosis. Dermatitis is rarely developed;
- systemic lesions: occasionally there is a feeling of weakness or heat and asthenia. Single - hypothermia or discomfort in the sternum;
- indications of diagnostic procedures and laboratory tests: sometimes decreases blood pressure indicators. Occasionally, the blood values of triglycerides or the level of blood pressure increase, the number of eosinophils increases or decreases, depression develops in the area of the ST segment on the ECG, and liver enzyme activity values change. The number of erythrocytes or the PTV index decreases individually, the number of leukocytes decreases or increases, and the weight increases.
Interactions with other drugs
The combination of vinpocetine and β-blockers (for example, pinodolol or cloranolol), and in addition to glibenclamide, clopamide with digoxin, hydrochlorothiazide and acenocoumarol does not lead to any therapeutic interaction. Occasionally, a slight additional effect was observed when combined with α-methyldopa, which is why one should constantly monitor blood pressure values when using these medications.
It is necessary to carefully combine Neurovine with substances that affect the work of the central nervous system, and, moreover, when administered simultaneously with the anticoagulant or antiarrhythmic treatment cycle.
Storage conditions
Neurovine needs to be kept in a dry place, closed from small children. Temperatures are a maximum of 25 ° C.
Shelf life
Neurovin can be used for a 36-month term from the time a pharmaceutical substance is manufactured.
Attention!
To simplify the perception of information, this instruction for use of the drug "Neurovin" translated and presented in a special form on the basis of the official instructions for medical use of the drug. Before use read the annotation that came directly to medicines.
Description provided for informational purposes and is not a guide to self-healing. The need for this drug, the purpose of the treatment regimen, methods and dose of the drug is determined solely by the attending physician. Self-medication is dangerous for your health.