Melatonin

Melatonin is a natural hormone of the body, but in addition it exists in an artificial form, which is used as an additive that provides a hypnotic effect. At the same time, this substance has antioxidant properties. This hormone acts as a natural regulator of the day regimen, promoting healthy sleep, as well as a quick awakening in the mornings and falling asleep in the evening.

For disorders of temporary adaptation, melatonin allows you to adjust the daily regimen and adjust the sleep and wake cycles. Thanks to the Melatonin tablets, it is easier to fall asleep in an inappropriate time period, sleep stabilizes and the frequency of nighttime awakenings decreases.

[1], [2], [3], [4]

Indications Melatonin

It is used in the case of such conditions and violations:

• insomnia ;
• conditions during which sleep disorders are observed;
• the need to regulate the biological cycle of sleep and wakefulness;
• the need for antioxidant effects to protect against the effects of free radicals;
• to stimulate immune function;
• stabilization of blood pressure and regulation of blood cholesterol values;
• prevention of the development of tumor pathologies;
• mental adjustment disorders;
• states of depression and anxiety;
• sleep stabilization in the elderly.

[5], [6], [7], [8]

Release form

The release of the drug is implemented in tablets - 12 pieces inside the cell plate.

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Pharmacodynamics

Melatonin is a sleep hormone and is produced inside the human body by the pineal gland, located in the brain base. This component is contained in products of animal nature, and it is also found in vegetable food, but in smaller volumes. Melatonin excretion, among other things, depends on the intensity of illumination. In the case of poor lighting, its output increases, and in the case of good light it slows down.

Inside the human body at night, approximately 70% of the daily volume of this hormone is usually produced. The effect of melatonin increases serotonin with GABA inside the midbrain and hypothalamus.

Melatonin is a solid substance that can dissolve or absorb fat; It is a powerful natural antioxidant. During the binding of this hormone, protection against the effects of free radicals is realized, causing an increase in the rate of aging processes and the appearance of malignant diseases. The specified element is able to pass into all cells, providing special protection to the nuclei. As a result, damaged cells are restored.

The drug has adaptogenic, sedative and hypnotic activity when administered in large portions; in addition, its immunostimulating and antioxidant effect is manifested. At the same time, its influence leads to a decrease in the number of attacks of headaches and the severity of stressful manifestations; regulation of neuroendocrine activity is also carried out.

[11], [12], [13], [14],

Pharmacokinetics

The effect of Melatonin begins after 1-2 hours from the moment of taking the drug inside.

The drug is subjected to the 1st intrahepatic passage, followed by transformation. Bioavailability is 30-50%. The drug can overcome the BBB.

The average half-life term is 45 minutes. Excretion is carried out by the kidneys.

[15], [16], [17], [18], [19], [20], [21], [22], [23],

Dosing and administration

It is required to take a medicine inside, without chewing a tablet, swallowing entirely. Melatonin washed down with plain water. An adult person is prescribed 1-2 tablets in the evening, and a teenager over the age of 12 years old is prescribed the 1st tablet.

It is recommended to take the medicine 30-40 minutes before bedtime. A day should consume a maximum of 6 mg of the drug substance.

The mode of drug use is chosen personally by the attending doctor.

When using sports nutrition containing melatonin, you need to constantly consult with experts.

[30], [31], [32], [33], [34]

Use Melatonin during pregnancy

Do not use the drug for breastfeeding or pregnancy.

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Contraindications

Among the contraindications:

• severe intolerance that occurs under the influence of drugs;
• myeloma or leukemia;
• diseases that are autoimmune;
• lymphogranulomatosis or lymphoma;
• epilepsy;
• diabetes.

Caution is required when appointing persons who need a high concentration of attention at work. In addition, it is extremely cautious when using hormone replacement therapy, hormonal disorders, and also for pathologies of an allergic nature.

[26], [27], [28],

Side effects Melatonin

Among the possible side effects that appear when using the medicine are: gastric discomfort and feeling of heaviness, depression, and heaviness in the head with headaches. In the event of such violations (or any other) is required to consult with your doctor.

[29]

Overdose

The use of more than 24 mg of the drug leads to memory disorders, prolonged sleep and disorientation.

In such cases, perform gastric lavage and appoint reception of enterosorbents. In addition, symptomatic actions are performed.

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Interactions with other drugs

The use of β-blockers and aspirin may cause a decrease in melatonin values.

The combination of drugs with sedative antidepressants or tranquilizers weakens the activity of melatonin.

The drug can affect the therapeutic activity of hormonal drugs.

The effect of melatonin contributes to an increase in the synthesis of benzodiazepines with specific endings. Therefore, this combination can only be used under the regular supervision of a doctor.

Combined administration with tamoxifen enhances its antitumor activity.

Use with methamphetamines causes potentiation of their serotonergic and dopaminergic properties.

The use of drugs leads to increased antibacterial effects of isoniazid.

[36], [37]

Storage conditions

Melatonin is kept in a closed place for small children at standard temperature elevations.

[38], [39], [40], [41], [42], [43], [44], [45]

Shelf life

Melatonin can be used for a 36-month term from the time the therapeutic agent is delivered.

[46]

Application for children

People under the age of 12 do not prescribe Melatonin. To stabilize sleep, this age group can eat food that contains this element (mostly animal). For products containing melatonin, you can consult a medical professional.

[47], [48], [49],

Analogs

Analogues of the drug are the substances Yukalin, Melapur with Melaton and Melaxen.

[50], [51], [52], [53], [54], [55], [56], [57]

Reviews

Melatonin receives good reviews - it is believed that it helps stabilize biological rhythms, and with it it has a positive effect on the quality of sleep processes and eliminates insomnia. Both patients and doctors talk about the good tolerability of the drug and the rare appearance of strong negative symptoms.

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