Terraflex

Teraflex is a medication used in the defeat of the ODA system. The drug stimulates the regeneration of cartilage tissue. Its active elements (glucosamine with chondroitin) are effective in the treatment of osteoarthritis.

The drug has anti-inflammatory effect on the cellular level, it stimulates the binding of internal proteoglycans and hyaluronic acid, and with it weakens the catabolic effects of chondrocytes, slowing the activity of certain enzymes that destroy cartilage (including elastase, collagenase, phospholipase A2 and proteoglikinaza with N-atsetilglikozaminidazoy). In addition, the drug slows down the formation of other components that can damage the cartilage tissue - for example, superoxide radicals; also slows down the activity of lysosome enzymes.

Indications Teraflex

It is used in such conditions:

• osteoarthritis of primary or secondary nature;
• osteochondrosis ;
• periarthritis of the humeroscapular character;
• fractures (to speed up the formation of callus).

Release form

The release of the therapeutic element is realized in capsules - 30, 60 or 120 pieces inside the bottle.

Pharmacodynamics

Chondroitin is a major component of cartilage. It reduces the activity of inflammation at an early stage, thereby inhibiting the degeneration of cartilage tissue. Helps relieve pain, improves joint function and reduces the need for the use of NSAIDs in case of osteoarthritis, which affects the hip and knee joints.

The human body itself contains glucosamine, which has a chondroprotective effect. In vitro and in vivo tests revealed that glucosamine hydrochloride stimulates chondrocyte binding of proteoglycans to glycosaminoglycans, as well as synoviocyte binding of hyaluronic acid.

Pharmacokinetics

With a single use of a therapeutic dose, the plasma index Cmax of chondroitin sulfate is recorded after 3-4 hours. The bioavailability values of the ingested dosage are 12%.

Inside the blood, chondroitin with its depolymerized derivative is 85% synthesized with individual intraplasma proteins.

At least a 90% portion of chondroitin is first subjected to metabolic processes involving lysosomal phosphatase, and then depolymerized with hyaluronidase, as well as β-glucuronidase with β-N-acetylhexosaminidase inside the kidneys with the liver and other organs.

Chondroitin with its depolymerized derivative is excreted mostly through the kidneys. The term half-life is 5-15 hours.

When ingested, glucosamine hydrochloride is almost completely absorbed inside the intestine and at high speed. The pharmacokinetic characteristics of glucosamine are linear with a standard portion of 1.5 g 1-fold per day. Higher dosages do not cause a proportional increase in the Cmax level of glucosamine.

More than 25% of the consumed portion of glucosamine moves from the blood plasma into the cartilage tissues, as well as the synovial membrane of the joint.

At the 1st intrahepatic passage, more than 70% of the substance is metabolized to form carbon dioxide, urea, and also water.

Excretion of the unchanged component occurs mainly through the kidneys and with urine, and another part is excreted in the feces. The term half-life is 68 hours.

Dosing and administration

It is necessary to use a medication orally, washing it down with plain water. Apply 1-well capsule 3 times a day. The therapeutic cycle lasts at least 2 months. In general, it is usually 3-6 months. When needed, the treatment course can be repeated with a 3-month interval.

Teraflex can not be used to eliminate the pain of a sharp nature. The weakening of the manifestations (especially pain) may not occur even after several weeks of therapy, and sometimes more. If there is no effect after 2-3 months of therapy, it is necessary to consult a physician.

Also, the patient needs to consult with the doctor in cases where the symptoms of the disease increase with the beginning of the use of drugs.

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Use Teraflex during pregnancy

Due to the fact that there is no information regarding the safety of the use and effectiveness of the drug during lactation or pregnancy, it is forbidden to prescribe it during the specified periods.

Contraindications

The main contraindications:

• thrombophlebitis;
• severe intolerance to the elements of the drug (allergy symptoms);
• tendency to bleeding;
• decompensated disorder of the kidneys or liver;
• use in people with allergies to seafood.

Side effects Teraflex

Among the adverse events:

• disorders affecting the work of the digestive tract: dyspepsia, vomiting, pain in the epigastric zone, bloating, nausea, constipation and diarrhea;
• immune disorders: signs of allergy, including urticaria, dermatitis, rashes (also maculopapular), erythema, pruritus, angioedema, and simple edema. If an allergy appears, it is necessary to cancel the therapy and consult a doctor;
• problems with NA function: headaches, insomnia or drowsiness, dizziness, as well as severe fatigue;
• other symptoms: there is evidence of the development of visual disorders, extrasystoles, and alopecia in the case of the administration of 1.2 g of chondroitin sulfate, but such cases are isolated.

Interactions with other drugs

The drug can be combined with GCS, and besides with NSAIDs.

Chondroitin sulfate is able to potentiate the effect of anticoagulants, which is why it is necessary to more closely monitor the blood clotting values during their combined use. Some sources report that in the case of a combination of warfarin with glucosamine, the MHC (INR) index may increase, and bleeding may appear. Because of this, when sharing drugs, you need to keep track of blood coagulation.

The therapeutic efficacy of Teraflex is enhanced when the patient receives magnesium with selenium and zinc, ascorbic acid, manganese salts, copper and retinol.

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Storage conditions

Teraflex must be kept in a place that is closed to small children. Temperature indicators - no more than 25 ° C.

Shelf life

Teraflex allowed to apply for a 3-year term since the production of the drug.

Application for children

Because the experience of use in pediatrics is limited, children do not prescribe Teraflex.

Analogs

Analogues of drugs are the substances Afenak, Tsefenap, Zelid plus with Rebon, Movex, and Teraflex advance.

Reviews

Teraflex receives rather ambiguous reviews - to some he really helped to cope with the disorders, but there are also comments that say that the drug had no effect. Of the negative, they also highlight the high cost of the drug.