Serrata

Serrata contains the element serratiopeptidase, which acts as an enzyme extracted from non-pathogenic genesis of the intestinal microbe - Serratia type E15; This microorganism has proteolytic properties.

This category of bacteria can break down fibrin with bradykinin, as well as other inflammatory conductors. At the same time, it has an anti-inflammatory and anti-edema effect and demonstrates an analgesic effect - releasing painful amines from inflamed tissues.

[1], [2]

Indications Serrata

The versatile drug activity of the drug leads to the fact that it is used for a variety of diseases from different fields of medicine.

Surgery and traumatology: fractures with dislocations,  sprains  and other injuries. In addition to this puffiness of various genesis (also arising after operations). As a prophylactic element used to prevent rejection of the transplanted organ.

Dermatology: acute dermatoses, which occur with the development of pain.

Plastic surgery: strengthening of microcirculation processes to prevent graft rejection, and also weakening of edema after performed operations.

ENT-organs: otitis with sinusitis and other inflammatory diseases (among them, the VDP), in which there is increased mucus formation and a problem with sputum discharge. In addition, it is used to improve the process of assimilation of antibiotics.

Gynecology: elimination of the edema of the mammary glands, which appears due to various pathologies, and with it to increase the rate of resorption of hematomas (for example, in the case of mastitis).

[3], [4], [5], [6], [7]

Release form

The release of the drug substance is made in enteric tablets - 10, 30 or 100 pieces inside the pack.

[8], [9], [10], [11]

Pharmacodynamics

Serrata demonstrates a high level of penetration into areas that are affected by inflammation, and at the same time it lyses necrosis tissue with their metabolic elements, reduces hyperemia and acts as a catalyst for the absorption and activity of antibiotics. In addition, the drug helps to dilute nasal secretions and reduces salivary viscosity, making the process of their elimination becomes easier.

Serratiopeptidase together with blood α-2-macroglobulins create an active complex in the ratio of 1k1, thereby masking the antigenicity of the enzyme without losing its therapeutic effect. In the future, the blood values of serratiopeptidase decrease, because in the area of inflammation the enzyme goes into exudate.

Cleavage of histamine and serotonin with bradykinin leads to a decrease in capillary dilatation and strengthens the strength of capillaries. The drug suppresses the elements blocking plasmin, which leads to an improvement in its fibrinolytic effect. Reducing edema and reducing microcirculation helps to improve sputum discharge.

[12], [13], [14], [15]

Pharmacokinetics

The active ingredient and additional elements of the drug are closed with a special enteric coating, which prevents the destruction of the tablets inside the stomach. As a result, the absorption is carried out inside the intestine. Inside the blood plasma, the Cmax index is recorded after the expiration of the 1st hour from the moment of use. A small part of the drug is excreted in the urine.

[16], [17], [18], [19], [20],

Dosing and administration

It is required to use tablets orally - 30 mg of the drug per day (1 tablet containing 10 mg of the active element, 3 times a day). Eating does not affect the absorption and therapeutic efficacy of the drug. A pill is swallowed whole, without chewing (so as not to damage its enteric coating), and washed down with plain water.

A variety of pathologies and different degrees of their intensity may require changes in the daily portion of the medication. To choose the minimum effective dosage, and in addition, the duration of use, should the attending doctor, given the clinical picture observed in the patient.

Use Serrata during pregnancy

During pregnancy or breastfeeding, it is possible to prescribe Serrata only in exceptional situations.

Contraindications

Among the contraindications:

• strong sensitivity associated with serratiopeptidase or other components of the drug;
• painful conditions during which blood coagulability is disturbed and the likelihood of bleeding increases.

[21], [22], [23]

Side effects Serrata

Serrarata may occasionally cause pain in the gastrointestinal tract, nausea, upset stools and vomiting.

In people with a predisposition to bleeding, nose bleeding may occur or blood may appear in the discharge of sputum.

There are also reports of the development of signs of allergy - in the form of a rash on the epidermis, itching, and urticaria.

[24], [25]

Overdose

Drinking too large servings of Serrata can trigger the potentiation of its negative symptoms and (sometimes) cause internal bleeding.

You must stop using the medication and perform the required symptomatic procedures.

[26], [27], [28]

Interactions with other drugs

It has been revealed that when combined with Serrata, potentiation of the medicinal activity of anticoagulants occurs. With the need for simultaneous use of drugs, the patient should be under the supervision of experienced doctors, who will, if necessary, adjust the dosage of the anticoagulant.

[29], [30]

Storage conditions

Serrata should be maintained at temperatures not higher than 25 ° C.

[31], [32], [33]

Shelf life

Serrata can be used for a 24-month term from the time the drug was manufactured.

[34], [35]

Application for children

It is forbidden to use the drug in pediatrics (under the age of 18), because its effect on the child’s body is not fully determined.

[36], [37]

Analogs

Analogs of drugs are means Movinaz and Fibrinaz.

[38], [39], [40], [41], [42],

Reviews

Serrata receives good reviews from patients who have used the drug for surgical, gynecological, trauma and inflammatory conditions - often it has worked quite effectively. Use in combination with antibiotics can reduce the period of the disease and speed up the process of easing the manifestations of pathology, which is also reported in the comments on the forums.

[43], [44]