Complications

Remantadin is an antiviral medication.

Rimantadine hydrochloride is an amidantane element derivative; demonstrates strong antiviral effect. This component is effective against influenza virus subtype A2, as well as B.

Remantadin slows down viral replication in the early stages of the cycle, possibly preventing the formation of the virus envelope. In genetic testing, it was revealed that the specific gene protein (virion-M2) plays an important role in the antiviral effect of the component relative to the influenza A virus.

[1], [2], [3], [4]

Indications Remantadine

It is used for the treatment of influenza in its early stages, and in addition to prevent the development of influenza during epidemics and tick-borne encephalitis.

[5], [6], [7], [8], [9], [10], [11], [12], [13], [14], [15], [16], [17]

Release form

The release of the drug is sold in capsules with a volume of 0.1 g or tablets with a volume of 0.05 g.

[18], [19], [20]

Pharmacodynamics

The drug has antiviral activity, slowing down the early phase of viral reproduction (after its passage into the cell) and blocking the transfer of viral genetic material into the cell cytoplasm.

It affects influenza virus subtype A, as well as tick-borne encephalitis (the so-called arbovirus). It is effective when applied at the initial stage of infection (within 6-7 hours after the onset of symptoms), thereby reducing the incidence of influenza and reducing the intensity of symptoms.

[21], [22], [23], [24], [25], [26], [27], [28]

Pharmacokinetics

The drug, although at low speed, is fully absorbed inside the gastrointestinal tract. Synthesis with blood protein - 40%. Indicators of the active element inside the nasal secretions 50% higher than its plasma level. Metabolic processes develop inside the liver.

The term half-life of a drug is 24-30 hours. Excretion is done through the kidneys.

If you do not adjust the dosage to persons with kidney failure, they accumulate the drug with the achievement of toxic indicators.

[29], [30], [31], [32], [33], [34], [35], [36], [37],

Dosing and administration

It is necessary to apply a medicine after the use of food, orally.

With the flu, the following scheme is used: 1st day - 3 times use of 0.1 g of the substance, 2nd and 3rd days - 0.1 g 2 times a day; 4th day - 1-fold intake of 0.1 g of the drug. To prevent the development of the disease - 50 mg of the drug every day within 10-15 days.

In the case of a tick bite, the drug should be applied during the first 72 hours - 2 times a day in a serving of 0.1 g.

[47], [48], [49], [50], [51], [52]

Use Remantadine during pregnancy

It is forbidden to appoint rimantadine pregnant.

Contraindications

Among the contraindications:

• renal or hepatic pathology;
• hyperthyroidism.

Caution is required when used in epileptics, with elevated blood pressure and atherosclerosis. Older people with elevated BP values increase the likelihood of developing a hemorrhagic form of stroke. If epilepsy is present in history, an epileptic seizure may develop.

[38], [39], [40], [41], [42]

Side effects Remantadine

Among the side effects:

• anorexia, nausea, stomach pain, dry oral mucous membranes and flatulence;
• anxiety, excitability or nervousness, headaches, drowsiness or insomnia, as well as a decrease in concentration;
• allergy symptoms.

[43], [44], [45], [46]

Overdose

When poisoning, there is nausea with emetic urging and a metallic taste in the mouth. In addition, psychedelic trip develops, during which panic, fear, hallucinations and delusions appear, and in addition, the intensity of thought processes increases.

In such situations, physostigmine is required to be injected intravenously - 0.5 mg for a child and 1-2 mg for an adult.

[53], [54],

Interactions with other drugs

Enveloping drugs and adsorbents weaken the absorption of the active element of drugs.

Substances that acidify the urine weaken the effects of rimantadine, while the means that alkalinize the urine, on the contrary, potentiate it.

The values of clearance of rimantadine are reduced when using cimetidine.

Remantadin reduces the effectiveness of anticonvulsants.

The blood indices of Cmax medication decrease when it is combined with aspirin, as well as paracetamol.

[55], [56], [57], [58], [59], [60], [61], [62], [63]

Storage conditions

Remantadin must be maintained at a temperature not exceeding 25 ° C.

[64], [65], [66], [67], [68],

Shelf life

Remantadin can be used for a 5-year term from the time the drug was manufactured.

[69]

Application for children

Cannot be used by children until the age of 7.

Children of the age group of 7-10 years are required to use 50 mg of the substance 2-fold per day, and for children over the age of 10, the same dose 3 times a day.

In severe conditions in children 3-7 years old, the drug can be used, but only at a dosage of 1.5 mg / kg, for 2 uses.

[70], [71]

Analogs

Analogues of drugs are the substances Olvirem, Algirem, Remantadin Ste and Tamiflu with Arbidol, and in addition Remantidin Akititab, Kagocel and Polirem.

[72], [73], [74], [75], [76]

Reviews

Remantadin receives good reviews as an effective preventive element that helps prevent the epidemic of influenza within closed groups and teams.

[77], [78], [79], [80], [81], [82], [83], [84], [85], [86], [87],