Pask

Pask has an active antibacterial effect (it has a medicinal effect on mycobacteria).

The drug shows an active bacteriostatic effect against M. Tuberculosis bacteria. The action of this drug is developed by inhibiting the formation of mycobacin, and in addition it occurs through the suppression of the formation of B9-vitamin. Due to this, the microbial capture of microbes by M. Tuberculosis is noticeably weakened.

[1]

Indications Easter cake

It is used in the combined treatment of  tuberculosis, which has a different shape and localization. Usually, Pask is used in people with tuberculosis who are resistant to other anti-tuberculosis elements.

[2]

Release form

The release of the substance can be in the form of a lyophilisate for injection fluids.

Also sold in granules for oral liquid - 5,52 g bags, 25 pieces inside the box.

Can be produced in tablets of 0.5 and 1 g.

[3]

Pharmacodynamics

The drug affects relatively actively breeding mycobacteria, almost without affecting the calm state of Mycobacterium tuberculosis. It has a weak effect on microbial pathogens located inside the cells.

[4], [5], [6], [7], [8], [9]

Pharmacokinetics

After oral administration, the drug is well absorbed at high speed.

It is rapidly distributed, penetrating into the tissues and all histohematogenous barriers. Inside the cerebrospinal fluid passes exclusively with inflammation of the lining of the brain. Exchange processes are carried out inside the liver.

Excretion occurs in acetylated form, mainly with urine. Small amounts of the medicinal component are excreted with the mother's milk, saliva and bile.

[10], [11], [12], [13], [14], [15]

Dosing and administration

For intravenous injections of the drug, 3% liquid is applied through an IV drip using an injection pump. At first, the injection rate is 30 drops / minute, and then (in the absence of systemic and local negative manifestations) it is increased to 40-60 drops (after 15-20 minutes). At the first injection, the size of the portion is 0.2 liters maximum, and then (if there are no negative symptoms) 0.4 liters. For a week, perform 5-6 introductions of drugs. You can also use the scheme with the introduction of fluid through the day (on the days of the break, the medication is taken orally - in granules or tablets).

The size of the daily dosage portion in adults is 10-12 g, and in a child - 0.2 g / kg. In the case of exhaustion or poor tolerability, and in addition to the elderly, 6 g of the substance is administered per day.

Tablets should be administered orally, after a period of 0.5–1 hours after a meal; they are washed down with alkaline mineral water or milk. In adults, the dosage per day is 9-12 g (it is divided into 3 uses). In children, it is the 2nd g / kg per day.

A liquid is prepared from the medicinal powder for ingestion (the lyophilisate from the bag is dissolved in warm boiled water (0.1 l)). Pask should be eaten after half an hour after eating. The finished solution of the drug can be stored for a maximum of 1 hour. The average adult dosage of drugs is 8-12 g per day; It must be divided into several uses.

[26], [27]

Use Easter cake during pregnancy

Cannot be used during breastfeeding or pregnancy.

[16], [17]

Contraindications

Among the contraindications:

• strong sensitivity to the drug substance;
• liver failure, hepatitis or hepatic cirrhosis;
• gastric ulcer;
• aggravated enterocolitis phase;
• amyloidosis affecting internal organs;
• myxedema, which is uncompensated;
• nephritis;
• decompensated stage of CHF;
• thrombophlebitis or hypocoagulation.

Caution is required when used in epileptics.

[18], [19], [20], [21], [22]

Side effects Easter cake

Among the side effects:

• vomiting with nausea, bloating, obstipation or diarrhea, loss of appetite and pain affecting the abdominal zone, and in addition hyperbilirubinemia or hepatomegaly; proteinuria, hematuria or crystalluria may also develop;
• rarely there is platelet or leukopenia, pernicious anemia or drug-induced hepatitis;
• allergy symptoms - fever, arthralgia, dermatitis, and bronchial spasm or eosinophilia;
• With the introduction of large portions of the drug, or in the case of its long-term use, myxedema, hypothyroidism or goiter develop.

[23], [24], [25]

Overdose

With drug intoxication, diarrhea and vomiting usually develop. More rarely, in the case of severe Pasco poisoning, there is a potentiation of negative symptoms and even the onset of psychosis.

[28]

Interactions with other drugs

The drug should be used in combination with other anti-tuberculosis drugs - this can significantly increase the effectiveness of treatment compared with monotherapy. It also significantly reduces the likelihood of the emergence of resistance to tuberculosis mycobacteria against the drug.

The introduction of Pasca along with isoniazid increases the therapeutic efficacy of the course.

Use in combination with streptomycin also potentiates the anti-tuberculosis properties of the drug.

Barbados with butadion in combination with the drug enhance its drug activity.

The combination with Dimedrol weakens the therapeutic effect of Pasca.

It is forbidden to inject the drug along with rifampicin, because this causes a violation of the absorption of the latter.

The introduction of the drug leads to the potentiation of the activity of aminophenazone and anticoagulants, as well as the toxic properties of difenin, and in addition weakens the absorption of cyanocobalamin.

During the use of the drug is prohibited to smoke and drink alcohol.

[29], [30], [31]

Storage conditions

Pask is required to be kept at temperature values of maximum 25 ° C.

[32], [33], [34], [35]

Shelf life

Pask can be used for a 3-year term from the moment of drug implementation.

[36]

Application for children

It is forbidden to use in children younger than 3 years old with a weight below 20 kg. To ensure a more accurate dosage, Pask children are prescribed in granules.

[37], [38]

Analogs

Analogues of the medication are the medicines Simpas, Pazer, Aminosalicylic acid and Pasconate, as well as Aquapask, Monopas and PAS Sodium, PAS-Fatol N, MAK-PAS and PASK-Akri.

[39], [40]

Reviews

Pask mostly receives positive reviews. It demonstrates high efficiency when combined with other anti-tuberculosis substances.

[41]