Paroxin

Paroxin has an antidepressant effect.

Indications Paroxin

It is used in such conditions:

• various forms of depression (severe, reactive, etc.), and in addition to this depression, against which there is a feeling of anxiety;
• treatment of panic disorders and prevention of their recurrence;
• therapy for alarming violations of a generalized nature, as well as the prevention of their relapses;
• PTSR;
• sociofobii.

[1]

Release form

The release of the drug produced in tablets of 20 mg; Inside the package contains 20, 30 or 60 tablets.

[2], [3]

Pharmacodynamics

Paroxetine is included in the category of drugs SSRIs with a powerful therapeutic effect, due to which Paroxin has an antidepressant effect. But at the same time, the chemical structure of the drug does not correspond to drugs from the group of the SSRI.

The antidepressant effect of drugs develops after 8–12 days of its systemic use. This reduces the severity of depression, sleep disorders and anxiety.

[4]

Pharmacokinetics

The drug is well absorbed inside the gastrointestinal tract, while the use of food or antacids does not affect the degree of its absorption. Bioavailability values range from 50-100%.

Synthesis with blood protein is approximately 95%. The therapeutic index inside the blood after oral use of drugs is noted after 5-8 hours. Equilibrium values of the drug reaches after 14 days of admission. Metabolism occurs at the 1st hepatic passage.

The excretion of the drug is carried out with urine and feces.

[5]

Dosing and administration

It is necessary to use tablets 1 times a day, together with food (it is recommended to take drugs in the morning).

For the treatment of depressive conditions, take 20 mg each day. If the drug effect is absent, the dose increases +10 mg per day until the patient's condition improves (at the same time, a maximum of 50 mg of the substance is allowed per day). The duration of drug use in acute depressive episodes may be several months.

With panic disorders, you need to take 40 mg of the drug per day, and therapy should be started with a portion of 10 mg per day, then weekly increasing it by 10 mg until the maximum permissible daily dose of 60 mg is reached.

[10], [11]

Use Paroxin during pregnancy

Prescribing the drug to pregnant women is prohibited.

Contraindications

It is contraindicated to use the drug during lactation or intolerance to the drug.

Caution is required when prescribing people with a tendency to develop seizures, kidney or liver failure, people over 65 years of age, and those taking an MAOI.

[6], [7]

Side effects Paroxin

The use of the drug may cause some side effects:

• symptoms of allergies, tremor, emotional instability, increased excitability of the central nervous system, insomnia, dizziness, feeling of irritability, and in addition, amnesia, delirium and concentration disorder;
• ear noise, deterioration of visual acuity, pain in the eye area and conjunctivitis;
• tachycardia, heart rhythm disorder, CHF, increased blood pressure and syncope;
• cough or runny nose;
• nausea, dysphagia, anorexia and gastritis;
• cystitis, dysmenorrhea, nephritis, oliguria, and in addition polyuria, sexual dysfunction and urinary retention;
• myositis or arthritis;
• furunculosis, dermatitis, pruritus, eczema, erythema nodosa, and in addition, peripheral puffiness, hyperhidrosis and urticaria.

[8], [9]

Overdose

If the medication is used in too large portions, nausea, sinus tachycardia, drowsiness, dilated pupils and vomiting may develop.

[12], [13]

Interactions with other drugs

Medications that inhibit the activity of hepatic enzymes, increase blood levels of Paroxin. The combination of drugs with drugs that induce the activity of hepatic enzymes weakens its properties.

Using drugs with warfarin increases the likelihood of bleeding. The drug should be carefully combined with anticoagulants.

The simultaneous use of drugs and products that contain tryptophan is prohibited. Also during treatment with the reception of Paroxin should not drink alcohol.

[14], [15], [16], [17]

Storage conditions

Paroxin is required to contain at temperature indicators not higher than 25 ° C.

[18], [19], [20]

Shelf life

Paroxin is allowed to be used within 36 months from the date of release of the medicine.

[21], [22]

Application for children

Do not use Paroxin in pediatrics (up to 18 years of age).

[23]

Analogs

Analogues of the medication are the means Sertralin, Adepress, Rexetin with Paxil, and in addition, Luxotel, Xet, Cyrestill, Plizil, Aktaparoxetin, Paroxetine hydrochloride, Apo-Paroxetine and others.

[24], [25], [26],

Reviews

Paroxin mostly receives positive reviews, although sometimes there are negative comments. Some patients talk about the high efficacy of the drug, but at the same time they note that it can cause addiction.