Caphid

Capozide is a medicine with antihypertensive and diuretic properties.

Indications Casipeda

It is used to reduce excessively elevated blood pressure.

Release form

The substance is released in tablets, 15 pieces each, packed in blister plates. Inside the pack there are 2 such plates.

Pharmacodynamics

A constituent element of the drug, hydrochlorothiazide is a thiazide-type diuretic that has a moderate effect. This component can weaken the reabsorption of sodium neon within the cortical segment in the region of the Henle loop. In addition, the drug reduces the level of blood pressure, changing the reactivity of the vascular walls, reducing the pressor effect of vasoconstrictor elements (such as epinephrine and norepinephrine), as well as potentiating depressor effects on vegetative ganglia. The medication does not affect the acid-base indicators.

The captopril component is an agent of ACE inhibiting the decrease in the secretion of aldosterone and the volume of its formation from angiotensin 1 and 2. It has a potentiating effect on coronary and renal circulation, and at the same time it weakens post-and preload, and also lowers blood pressure. This substance has a more pronounced vasodilating effect on arteries than veins.

Prolonged use of drugs leads to a decrease in platelet aggregation, increased blood supply to ischemic areas of the myocardium, and in addition, it weakens the intensity of hypertrophy of arterial membranes and myocardium, which has a resistive character.

Dosing and administration

Capozide should be taken as follows: 1 tablet, orally, 1-fold per day. Perform this procedure should be 60 minutes before eating.

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Use Casipeda during pregnancy

It is forbidden to appoint Caposide to lactating or pregnant women.

Contraindications

Among the contraindications:

• the presence of intolerance with respect to the components of drugs, sulfonamide derivatives, as well as diuretics of a thiazide type;
• tachycardia;
• Horse Syndrome;
• disorders of renal activity, having a pronounced form;
• violations in the liver in a serious degree (pre-coma or hepatic coma);
• decreased values of blood pressure;
• cardiogenic shock;
• SWF;
• use in people who have recently undergone a kidney transplant;
• arterial stenosis of a single kidney or a 2-sided form of the disease;
• hypertrophic cardiomyopathy of obstructive nature;
• mitral or aortic stenosis;
• edema Quincke (history of the disease, the disease is caused by the use of ACE inhibitors).

Caution is required when using the drug in these situations:

• combination with GCS, procainamide, lithium agents, cytostatics, as well as immunosuppressants or allopurinol;
• elderly people (age over 65 years);
• scleroderma, nodular form of periarteritis, as well as SLE;
• gout, hypokalemia, -volemia or -natriemia, and in addition hypercalcemia, collagenoses or proteinuria;
• problems with renal function, which have a moderate nature.

Side effects Casipeda

Taking medication can cause some side-effects:

• disturbances in the metabolic processes: hypermagnesia, uricemia, -lipidemia, and -glycemia;
• problems with the urinary function: glycosuria, proteinuria, pollakiuria, and in addition polyuria or oliguria. Occasionally, there is hyponatremia or an increase in serum creatinine, potassium ions and urea levels. Prolonged reception can lead to a disorder of kidney activity or nephritis;
• disorders in the hematopoietic system: increasing the titer of antibodies of antinuclear type, leuko-, neutro- or thrombocytopenia, eosinophilia, lowering of hematocrit and anemia (may have aplastic or hemolytic form);
• lesions affecting the activity of the PNS or CNS: tremor, dizziness, convulsions, paresthesia, as well as ear noise, visual disorders, depression and ataxia. There may also be a feeling of drowsiness, weakness, fatigue or depression, sleep disorder and headaches;
• violations of the digestive function: hepatitis, hyperbilirubinemia, increased activity of hepatic transaminases, cholecystitis of acute type and cholestatic jaundice. In addition, hemorrhagic form of pancreatitis, abdominal pain, constipation, weakening of appetite, epigastric discomfort, vomiting, diarrhea, or nausea may occur. Prolonged use causes gingival hyperplasia or taste disorder;
• lesions of dermatological nature: exfoliative form of dermatitis, TEN, polyforma erythema, eruptions on the epidermis (exanthema) and Stevens-Johnson syndrome. On the form of such epidermal changes, joint or muscle pain, vasculitis, and an increase in temperature can be noted. Occasionally, alopecia, onycholysis, psoriasis-like skin reactions and photosensitivity are noted;
• allergic manifestations: Quincke's edema in the larynx, lips, tongue or throat, as well as mucous, limbs and face. Occasionally hives occur;
• disorders of respiratory activity: sinusitis, dry type cough, laryngitis, respiratory insufficiency, runny nose and bronchial spasm;
• disorders of VEB indicators: dry mouth mucous, thirst. Occasionally, the secretion of tear fluid decreases;
• problems with the work of CAS: a decrease in the values of blood pressure in a pronounced form, accompanied by dizziness and a sense of weakness. In addition, swelling in the legs, heat, headaches, a feeling of rhythm of the heartbeat, flushing of blood to the face and tachycardia;
• other symptoms: impotence and progression of already existing myopia.

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Overdose

Poisoning with drugs leads to the potentiation of negative manifestations. Symptomatic measures are taken to eliminate them.

Interactions with other drugs

Methenamine sometimes leads to a weakening of the therapeutic properties of hydrochlorothiazide - by increasing the alkaline urine response.

Combination with diuretics of potassium-sparing type (for example, with amiloride, spironolactone, and also triterene), heparin, and potassium salts leads to the appearance of hyperkalemia.

Kolestyramin with colestipol hydrochloride slow down and decrease the degree of absorption of hydrochlorothiazide.

Combination with methyldopa causes the development of erythrocyte hemolysis.

When combined with diazoxide, the drug enhances hyperuricemic, hypotensive and hyperglycemic properties of hydrochlorothiazide.

Simultaneous use with medications that slow down the activity of COX, indomethacin, and also with the edible salt reduces the hypotensive effect of the drug, and also reduces the absorption of hydrochlorothiazide.

Combination with drugs that have an intensive synthesis with protein leads to the potentiation of a diuretic effect.

Lithium agents inhibit the excretion of lithium ions, which leads to the potentiation of their damaging effects on the heart and the central nervous system.

Application along with hypnotics, ethyl alcohol, tricyclics, MAOI, ganglioblocators, and in addition with verapamil, β-adrenergic blockers, nitrates, as well as diuretic-type diuretics, potentiates the antihypertensive effect of drugs.

Hydrochlorothiazide potentiates the effect of medications used in surgical operations that initiate anesthesia and anesthesia (among them triethiodide gallamine, as well as tubocurarin chloride).

The hepatic metabolism of captopril slows down when combined with cimetidine, resulting in plasma captopril values increase.

Caphidum potentiates the negative effect of SG, especially when combining the drug with carbenoxolone, salicylates, and also with laxatives, penicillin G, diuretics, hormones of the adrenal cortex and amphotericin B.

The medication weakens the effectiveness of epinephrine, antidiagnostic drugs, antidiabetic drugs for ingestion and norepinephrine, and also lowers the excretion of quinidine.

The drug increases the digoxin levels by 20% in the blood plasma, and in addition increases the level of bioavailability of propranolol.

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Storage conditions

Caphodic can be kept in a place protected from moisture at a temperature of not more than 25 ° C.

Shelf life

Capposide is allowed to be used within 36 months of the release of the therapeutic agent.

Application for children

The medicine is not used in pediatrics (children under 18 years of age).

Analogues

Analogues of the drug are drugs Kapotiazid, Normopres, as well as Kaptopres-Darnitsa.

Reviews

Kapozid receives quite good reviews - patients note that he has high drug efficacy and rarely causes the development of negative symptoms, even with prolonged use.