Jinntropin

Gentropine is a drug of STH, which has a stimulating effect on growth processes.

Indications Gintropina

It is used to treat such disorders:

• osteoporosis ;
• observed in the presence of a deficiency of STH slowing the growth processes in the child;
• insufficiency affecting the renal function, in which growth retardation is recorded;
• Prader-Willi syndrome;
• severe immunodeficiency, accompanied by weight loss;
• with tissue regeneration and healing of burn areas in the period after surgical procedures;
• Ulrich syndrome;
• as HRT for an adult.

Release form

The release of the medicamentous element occurs in the form of a powder for the manufacture of injection liquid, inside the bottles.

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Pharmacodynamics

Dzhintropin - a biosynthetic somatotropin, created with the help of genetic engineering. Inside the bacterial DNA (intestinal rods), the STH gene is introduced, and then the bacteria contribute to the synthesis of full-value somatropin.

The composition of the drug and its effect are identical to the human STG produced by the pituitary gland. It is a polypeptide containing 191 amino acids. Promotes the stimulation of skeletal growth - by affecting the epiphysis of the bones of the tubular form. In addition, the drug activates the processes of binding collagen with chondroitin sulfate.

Has anabolic properties - increases the rate of delivery of amino acids inside cells, as well as binding of protein from them. Increases the volume of muscle cells, thereby increasing muscle mass.

Along with this, the drug affects fat metabolism: it reduces the volume of adipose tissue. Also promotes the retention inside the body of mineral salts with nitrogen and liquid. Increases blood sugar levels by inhibiting insulin production.

Pharmacokinetics

The drug exposure lasts between 12-48 hours.

Dosing and administration

Enter Dzhintropin necessary s / k method, once a day, at night. The injection site should be constantly changed to prevent the appearance of lipoatrophy. To raise the lyophilisate is necessary only in the solvent attached to it. The finished medicine has a transparent shade. If the liquid contains particles of undissolved powder or has a murky color, it is prohibited to use it for injection.

Choice of portions is necessary, given the degree of deficiency of STH, therefore the scheme and duration of drug use should be prescribed exclusively by the endocrinologist.

For the child, daily portions equal to 0.07-0.1 IU / kg are prescribed. Therapy should be started from an early age and continue to be carried out for several years before the onset of puberty (or until the epiphyses of tubular bones are closed).

With Ulrich's syndrome and kidney failure, complicated by a delay in the growth process, the drug is used in a daily dosage of 0.14 IU / kg. Increase the portion should be on the 2nd year of the therapeutic cycle. If the dynamics of growth is not enough, the dosage should be increased by the first year of therapy.

An adult is first prescribed a portion of 0.45-0.9 IU per day, then increasing it taking into account the effect.

Use Gintropina during pregnancy

Use Dzhintropin during pregnancy is prohibited.

Contraindications

The main contraindications:

• the presence of strong sensitivity with respect to the drug;
• neoplasms in the brain;
• closure of osseous epiphyses.

Along with this caution is needed when appointing people with hypothyroidism, but also with diabetes mellitus or increased rates of ICP.

Side effects Gintropina

The introduction of a drug substance can cause such side effects:

• headache;
• hyperglycemia;
• feeling tired or weak;
• increased rates of ICP (among the symptoms - vomiting, eye disorders, nausea and with it headaches);
• the appearance of hypothyroidism;
• leukemia;
• the appearance of hyperemia, and in addition to this itching or a strong swelling in the injection zone, as well as the development of lipoatrophy (reduction in body fat);
• destruction of the integrity of the cartilage in the region of the head of the femur;
• the appearance of rashes on the epidermis;
• fluid retention.

Such manifestations are temporary and depend on the size of the portion of the drug.

Less common are the following negative symptoms: pancreatitis, gynecomastia, swelling in the optic nerve disk, auditory disorder, acceleration of growth processes, hip subluxation in the child, and in addition progression of scoliosis and malignancy of the nevus that the patient already had.

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Overdose

Poisoning first causes hypo-, and then hyperglycemia. Constant prolonged intoxication provokes the appearance of hypothyroidism, acromegaly, and also gigantism.

Interactions with other drugs

Substances of SCS lead to a weakening of the therapeutic properties of STH.

Also, the medicinal effectiveness of the medication is affected by estrogens, anabolic and thyroid hormones.

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Storage conditions

Dzhintropin must be kept at temperatures ranging from 2-8 ° C. The finished medicinal substance is allowed to contain at temperature values of 2-8 ° C for a period of 14 days.

Shelf life

Gentropine can be used within 36 months of the release of the therapeutic agent.

Analogues

Analogues of the drug are preparations Genotropin with Biosome, Ansomon, Rastan, Humatrop, and Somatropin and Norditropin.

Reviews

Dzhintropin, used in bodybuilding, based on comments left on the forums, begins to affect the second month of use, while its use should be accompanied by a diet with carbohydrate intake and training. The full cycle should last at least 3 months.

To get the desired effect, you must adhere to a strict daily routine and change your lifestyle - start a specific diet, exercise, give up smoking and liquor, and also have a lot of rest.

It should also be borne in mind that stresses have a negative effect on the state of the muscles, so when trying to get mass, you should try to avoid stressful conditions.

Before you start using drugs, you need to carefully evaluate all the risks and benefits, as well as consult a sports doctor who can choose the optimal course and dosage, taking into account the expected effect. Selecting a portion should be individually, with a gradual increase in the course of adaptation of the organism to a changed metabolism. It is necessary to understand that if you do not take into account these nuances, the drug can cause serious damage to the patient's health.

In general, the medication is usually tolerated without complications. In the reviews, it is noted that negative symptoms appear when injections of dosages amounting to more than 10 IU. Many people have experienced such signs as fatigue, severe headaches, significant fluid retention, changes in color perception, rashes and itching in the area of drug administration. During the first weeks of using Gentropine, there is an ache in the joint area.

Among the minuses of the drug is the need for its injection. Also, many note the presence of side effects and a high price, as the cycle of therapy should be at least 90 days.