Nolitsin with cystitis

Cystitis is a very unpleasant disease, which is accompanied by pain, burning, irritation, painful urination. The peculiarity of the disease consists in the fact that it arises suddenly, in the form of seizures, and is accompanied by severe pain. Requires immediate emergency care. Then you need to call an ambulance. It is recommended that the patient be hospitalized for further treatment. There are many methods and means of treatment. As practice shows, one of the most effective means of pain relief is nolycin in cystitis.

Indications Nolycin for cystitis

Nolitsin is recommended for use in various forms of cystitis, including cystitis of bacterial etiology. Also prescribed for other bacterial diseases of the gastrointestinal tract and urogenital system. Virtually all types of genitourinary infection require the use of nolicin. Indications for use may be even some venereal infections, including uncomplicated gonorrhea, trichomoniasis, chlamydia. In some cases, it is used to treat and prevent salmonellosis, brucellosis, various intestinal infections, travelers' diarrhea.

The drug is prescribed for staphylococcal infection, including, and for methyl-sensitive strains of microorganisms. It is used for the treatment of escherichiosis, cytrobacterium, ierisyniosis, enterobacteriosis, proteas, various types of protozoa, hemophilic infections, legionellosis.

Nolycin is characterized by activity against clostridia, petococci, cholera. It is an effective tool for the treatment and prevention of purulent-septic, inflammatory diseases, bacteremia and sepsis.

Nolitsin with chronic cystitis

By noliticin is meant an antibiotic belonging to the group of second generation fluoroquinolones. The main active substance is norfloxacin. The principle of action is that it creates bactericidal concentrations of the substance in the digestive tract, as well as in the genitourinary tract.

The drug is prescribed for chronic cystitis of bacterial etiology. Thus, it exhibits high activity against such groups of microorganisms as gonococci, cholera, escherichia, hemophilic rod, shigella, citrobacter, compilblobacter, meningococci.

It is inappropriate to use nolitsin in the treatment of cystitis caused by ureaplasms, bacteroides, peptococcus, fusobacteria, treponema and clostridia, since antibiotic is resistant to these microorganisms.

The mechanism of action is mainly based on the bactericidal effect, which is achieved by binding to DNA-gyrase. As a result, the process of inhibition of bacterial deoxyribonucleic acid occurs. This leads to supercoiling of the bacterial DNA chain, then further destabilization is noted. Subsequently, the DNA breaks up into smaller fragments.

The route of administration is oral. The therapeutic effect can be achieved in the shortest possible time. The main absorption and accumulation occurs in the genitourinary and gastrointestinal system. Complete absorption occurs over a period of 60 minutes to 90 minutes. In order to minimize the risk of side effects, it is necessary to drink plenty of water, in particular, you need to drink at least 2 liters per day.

Eliminates the body from the antibiotic with urine predominantly. Therefore, care should be taken to treat people who suffer from kidney and liver diseases, because these organs are the ones with the greatest burden on the body. Also, a small dose of the drug is excreted from the body with feces.

The antibiotic has a specific structure, specific mechanisms of activity, as a result of which it exhibits a high activity against bacteria that are resistant to norfloxacin. The use of nolicin is associated with the risk of developing a cross-reactivity reaction to fluoroquinolone drugs. Stability is due to the presence of a mutation in the bacterial genome, in particular, when encoding DNA gyrase. In addition to the mutational effect, during the treatment with antibiotics the permeability of the bacterial cell wall changes, which changes their sensitivity to the antibiotic.

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Nolitsin with cystitis with blood

If the cystitis is accompanied by blood - this is a negative sign, which indicates that a serious complication of cystitis develops. Most often it is an inflammatory process, which is accompanied by an intense inflammatory process, a lesion of the ureters and kidneys. Also, the activity of tissues and cells is significantly transformed, the permeability of the circulatory system, vessels changes. With increased permeability of blood vessels, heavy bleeding occurs. It is dangerous for the further progress of the inflammatory process, as well as the ability to develop further puffiness, necrosis.

With cystitis with blood, self-medication should not be dealt with, since the risk of complications is extremely high. It can be various complications, up to severe complications from the kidneys, urinary tract. Complications can progress, up to the development of severe renal and hepatic insufficiency. Therefore, the first thing to do is to consult a doctor for qualified medical care. Appointments can be made only on the basis of the results of clinical research, examination, laboratory and instrumental research results.

One of the drugs of choice for cystitis with blood is nolycin, but it can not be used alone, so in this case it is not advisable to discuss the optimal course of treatment and dosage. In each case, the treatment regimen will be strictly individual.

Nolitsin with acute cystitis

Effective in the acute form of cystitis. But appoint it yourself, without first consulting a doctor. This is due to the fact that the doctor also does not arbitrarily designate this drug. This is a rather complex drug, the basis for the appointment of which is the result of laboratory research, in particular, bacteriological inoculation.

Together with bacteriological culture, an analysis is made of the sensitivity to medicinal products. So, during this analysis, the sensitivity of the microflora to the drug is determined, the optimal dosage is determined, which will have the necessary effect on the body. In accordance with the results of the analysis, the optimal dosage, concentration of the drug is prescribed, the scheme and duration of treatment are selected.

It should be noted that the use of nolicin requires a certain diet. In particular, the use of alcohol in conjunction with nolicin is strictly contraindicated, since in complex these substances cause the formation of complex toxic complexes, the removal of which from the body is difficult.

Also, the appointment should take into account the sensitivity of other bacteria, as well as cross-reactions. Many of the bacteria show high resistance to this antibiotic. He also has numerous contraindications. In each individual case, the choice of the regimen is adjusted in accordance with the contraindications, the current state of the patient. Traditionally, the course of treatment is presented for 4 days. At the same time take the pill with an interval of 11 hours. Depending on the individual characteristics and specificity of the course of the disease in each individual case, the treatment regimen is adjusted. However, this standard scheme is the base from which the different treatment options are based.

Release form

The drug is taken in the form of tablets. Which contain 400 mg of active ingredient - norfloxacin. The tablets are round in shape, coated. The package usually contains 20 tablets.

Tablets from cystitis nolitsin

Nolitsin is used for various forms of cystitis, including acute and chronic. Cystitis can be any etiology. The highest activity of nolycin is in relation to staphylococcal and streptococcal infection. Promotes the removal of inflammatory processes, the normalization of metabolic processes, the restoration of damaged tissues.

It is taken orally before meals. The treatment regimen for each patient is strictly individual and should be based on the results of laboratory and instrumental studies. Self-medication in this case is strictly forbidden, since numerous complications can be obtained, such as increased inflammation, allergic reaction, necrosis of inflamed tissues, development of increased permeability of blood vessels and tissues, impaired lymph exchange between tissues and cells.

It is known that the drug has a pronounced bacteriostatic effect, so it can be accompanied by the development of the inflammatory process, its progression, the development of dysbacteriosis. All this can only intensify the inflammation, provoke tissue necrosis. The most dangerous complication is the development of hepatic and renal failure, which can progress up to complete failure and kidney failure. All this speaks in favor of the fact that self-medication still should not be dealt with, but it is advisable to consult a doctor who chooses the optimal treatment regimen and will monitor the treatment process.

During treatment it is necessary to monitor the effectiveness of treatment. For this you need to periodically make recommended laboratory and instrumental studies, which will show. Is there a need for an intermediate correction of the current treatment regimen.

In the most general form, the standard treatment regimen is used. So, take the drug should be on the pill once every 11 hours, about 1.5-2 hours before meals. When treating, you need a lot of drinking (pure water) to reduce the burden on the kidneys and ensure the timely excretion of metabolites.

Pharmacodynamics

The action of the drug is based on the active substance - norfloxacin. This antibacterial agent (antibiotic), which shows a high antibiotic activity against many Gram-positive, Gram-negative microorganisms, and sometimes - for fungal infection, in particular, fungi of the genus Candida. Nolycin is also active against microorganisms such as mycoplasma, ureaplasma, chlamydia, gardnerella, and other forms of microorganisms that are difficult to treat.

It should also be noted that the drug is active against various forms of intestinal infection. It also affects various forms of mixed infection (that is, mixed forms of infection, which form associations that include different groups of microorganisms that form stable bonds among themselves).

The drug is one of the few that acts against biofilms - stable microbiological formations, which combine various microorganisms, possibly fungi, forming a single habitat. They form a single matrix, form stable links between themselves. In biofilms, the properties of each microorganism change. First of all, they are formations that increase the resistance of microorganisms to the action of antibiotic drugs. There are difficulties in the penetration of the drug inside the matrix. It is also worth noting that stability in biofilms is more rapid. So, if one of the microorganisms has acquired stability, others will immediately become stable, since there is a close relationship between them, and optimal conditions for the formation of cross reactions in the matrix are formed.

Also uniqueness of this drug is that it manifests activity against such resistant forms of microorganisms as dysentery, Pseudomonas aeruginosa, gonococci. It also exhibits activity against methylenensensitive (resistant) forms of staphylococcus aureus. It is also active against hospital strains, which are difficult to treat because they have a high degree of resistance. The danger is that they can also have multiple persistence. He is also active in regard to asinetobacter, stable forms of enterococci. However, activity with respect to anaerobic forms of microorganisms does not manifest.

Refers to preparations of the antibiotic series, a group of fluoroquinolones. The principle of action is that the active substance suppresses the enzymatic activity in the bacterial cell, in particular, the activity of DNA-gyrase, which is responsible for supercoiling the DNA, is inhibited. As a result, there is a blockage of the basic cellular processes, which leads to the impossibility of cellular reproduction, and further death of the microorganism.

A distinctive feature of nolycin, and other preparations of the group of fluoroquinolones, is their resistance to beta-lactamase, which is a special kind of enzyme that can be produced by bacterial cells during development. It is these enzymes that often inactivate the action of the antibiotic, which leads to the development of resistance.

Pharmacokinetics

Nolitsin is a drug belonging to the group of fluoroquinolones, which is taken 1-2 times a day, while washing with a lot of water. Simultaneously, you can not eat food, because there is an active absorption of nutrients, and absorption of the active substance of the drug while reducing. This significantly reduces the activity of the drug.

The level of metabolism of the drug is low. In the intestine, the main absorption of the drug occurs. Thus, up to 30-40% of the drug is absorbed in the intestine. At the same time, only 15% of the drug binds to the blood plasma. Everything that has not been assimilated, and not connected, is gradually eliminated from the body. The main percentage of the undigested substance is excreted with bile, urine, and also through the intestine. When removed from the bile, the substance re-enters the intestine, resulting in a reabsorption, and the substance re-enters the blood, the circle of metabolism repeats.

The molecules of the drug bind to the blood plasma, and also to each other. The distribution of bound molecules through the organs of the abdominal cavity occurs. The main accumulation of the substance occurs in the kidneys, organs of the urogenital tract. Therefore, nolicin has the ability to penetrate the blood-brain barrier. The drug has the ability to bind to the inflamed tissue as well, resulting in a recovery, removal of the inflammatory process (through the synthesis of anti-inflammatory factors, histamine).

The maximum concentration of antibiotic in the blood can be achieved in the blood plasma within 1-2 hours after taking the antibiotic inside. The effective effect of the applied dose lasts about 12 hours. During the day, the main part of the drug is eliminated from the body. In this case, the bulk accumulates in the parenchymal organs, in particular, in the ovaries, uterus, prostate, bladder. To maintain the optimal therapeutic dosage of the drug in the blood, it is necessary to take the drug every 12 hours. If this regime is violated, the dosage of the drug in the blood decreases significantly, which leads to a decrease in the activity of the active substance.

Dosing and administration

Nolicin is taken orally at 400 mg every 11 hours. The course of treatment varies in wide intervals - from 5 days to 3 months, depending on the severity of the disease, the form of cystitis, possible complications.

• How and how much to drink nolitsin with cystitis?

Zittite with nolicin should be treated only under the strict supervision of a specialist. Periodically, it is necessary to conduct control laboratory and instrumental studies. Take the inside of the pill twice a day, before eating. It is important to comply with the mandatory condition of treatment - drink plenty of water. Also, when treating with nolicin, a number of mandatory rules should be observed.

First of all, you need to monitor the amount of liquid drunk during the day. This amount should not be less than 2 liters. As soon as the pill is drunk, it should also be washed with plenty of water (about 2-3 cups), this will minimize the risk of complications on the kidneys, and also reduces toxic effects on the kidneys.

In the treatment it is also important to monitor daily diuresis: So, the day must be allocated the necessary amount of urine, corresponding to the age norms and treatment regimen. For monitoring these indicators can be clarified by the doctor.

It is impossible to overexert, carry out heavy physical exertion, as this will help create an additional burden on the body. It is also important to monitor changes in the body, in particular, to monitor the body's basic indices, pain sensations. It is important not to allow the development and progression of pain in the tendons (this is an unfavorable prognostic sign when treating with nolicin). When the first signs of pain in the joints appear, immediately stop taking the drug.

It is strictly forbidden to drink alcohol and nolicin, as this leads to the formation of complexes that have a toxic effect on the body. Do not sunbathe in the sun, swim in an open pool, overheat. Also, avoid direct exposure to the sun's rays on any areas, especially the organs in the lumbar region and kidneys.

Also it is not recommended for the period of treatment, to sit behind the wheel, as the concentration of attention is significantly reduced, dizziness may develop, especially in a tense situation. It is not necessary to drive a vehicle at least in order to avoid creating emergency and potentially dangerous situations on the roads for other people. Also, do not work with mechanisms that require increased attention.

The treatment regimen for different forms of the disease can be different. It is necessary to consult with a doctor and select their own, strictly individual form of treatment, but in general terms it can be said that it is recommended to take 400 mg 1-2 times a day. Duration of treatment also varies within wide limits - from 1 week to 2-3 months. The longest course of treatment is 2-3 months with a chronic form of the disease. In uncomplicated forms of the disease, the course of treatment is usually an average of a month.

Light forms require treatment lasting up to 1-2 weeks. It must also be taken into account that nolycin can be prescribed for prophylactic purposes. For example, it can be prescribed to patients suffering from chronic forms of cystitis during a long journey. In this case, usually prescribed on a tablet twice a day. Preventive maintenance is carried out for some time before a trip, and also during the trip. But with the preventive purpose the drug can not be taken for more than 3 weeks.

Also, a drug is used to prevent sepsis in neutropenia, immunodeficiencies, progressive cystitis. It is recommended for preventive purposes for women during menopause. In order to prevent the recurrence of newly cured cystitis, you should also take nolycin (not more than 200 mg at a time). People prone to chronic forms of cystitis, and other diseases of the genitourinary system, it is recommended to take with a preventive purpose. It is prescribed for the prevention of cystitis with urethritis, various vaginal infections in women, against a background of dysbacteriosis and intestinal infections. In some cases, nolycin in cystitis can be replaced by the closest analogues.

Nolitsin with cystitis in women

Cystitis is more susceptible to women, as this is facilitated by the anatomical and physiological characteristics of the female reproductive system and the urogenital tract. This is the proximity of the intestine and the vagina to the urogenital tract, as a result of which infection easily penetrates the genitourinary system. Also, a shorter urogenital tract, compared to men, leads to the fact that the infection spreads faster along the ascending path and penetrates into the ureters, kidneys.

In addition, the development of cystitis in women can contribute to the development of hormonal disorders, restructuring, dysfunction of various organs. Often observed against a background of hormonal imbalance, which accompanies changes in the female reproductive system. Appear during perestroika in adolescence, during pregnancy, a few days before menstruation, with dysfunction of the ovaries, during menopause. Often you have to deal with senile cystitis, which develop against the background of physiological changes, hormonal imbalance, microbiocenosis disorders.

Cystitis often appears due to age-related changes in the body, against aging, various diseases (infectious, venereal, dermatological, rarely somatic, leprosy, erythema).

Also, cystitis can be a consequence of hypothermia, prolonged use of certain medicines, including the use of hormonal contraceptives.

Women should be particularly careful in selecting a regimen of treatment with nolicin. It is necessary to consult a doctor for advice, because self-treatment can be fraught with serious consequences. Usually for women the dosage of the drug is practically the same as that for men. Sometimes the scheme may vary depending on the characteristics of the physiological state of the body. Thus, with menstruation, it is advisable to reduce the dosage of the drug. At pregnancy the preparation is not recommended for reception.

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Application for children

This drug is quite strong and toxic, therefore its use is allowed only from the age of 18 years. In some sources, you can find information that indicates the possibility of using this tool from 15 years. However, in any case, use at the age of 15 years is prohibited, since it can lead to irreversible consequences, exerting a powerful load on the kidneys and liver of the child, which are already not sufficiently formed.

Use Nolycin for cystitis during pregnancy

During pregnancy, take nolicin is prohibited, because it is quite strong and toxic, which has the ability to penetrate the transplacental barrier. It is a threat to the normal development of the fetus, sometimes dangerous for his life.

Contraindications

The drug is quite potent, refers to antibiotics of a new generation, therefore it has a number of contraindications. All of them can be conditionally divided into relative contraindications, which presuppose the presence of various variants that will allow to prescribe the drug with observance of certain conditions and forms of application. Absolute contraindications are also identified, which imply that the drug can not be used under any circumstances.

So, nolitsin is absolutely contraindicated in case of pregnancy, and the period of breastfeeding, and children under 18 years. Also it is not necessary to appoint it in cases of individual intolerance of fluoroquinolones, and other components of the drug. Also absolutely contraindicated drug with congenital deficiency of the enzyme glucose-6-phosphate dehydrogenase (because the risk of anemia increases dramatically). Completely contraindicated in epilepsy, atherosclerosis, hepatic and renal failure.

 Relative contraindications include porphyria, inflammatory processes in the region of joints and ligaments, ruptures of tendons. Also, with caution should prescribe the drug to patients with various diseases of the kidneys and liver, because it is metabolized with urine and bile, and this significantly increases the burden on the liver and kidneys. Also, it is not possible to prescribe a drug for arrhythmias, bradycardias, tachycardias, and other heart rhythm disturbances. Malignant tumors, in particular, myasthenia gravis, are also a relative contraindication to the administration of nolicin.

Take care with patients who have a drop in potassium in their blood (hypokalemia), and also with some antipsychotic drugs, antidepressants.

Side effects Nolycin for cystitis

Against the background of taking nolycin, there may be various side effects and complications. They can touch different organs and systems. Most often, there are abnormalities from the digestive tract: nausea, diarrhea, vomiting, bile taste in the mouth, a decrease in appetite. Also, there may be various pathologies from the urinary system, for example, inflammation of the kidneys, excessive urinary leakage. There may be blood in the urine, pain when urinating. In the analyzes, protein in the urine, urine salts can be observed, as well as an increase in the level of creatinine in the urine.

From the side of the cardiovascular system, there is often the appearance of creatinine in the blood, arrhythmias, palpitations, vasculitis. Also, often you have to face a headache, a noise in your ears. Many patients on the background of taking this drug note increased irritability, depression, excessive fatigue, insomnia. The condition can progress up to loss of consciousness, fainting, constant dizziness. In clinical analyzes, leukocytopenia is registered against the background of an increased number of eosinophils. Also, there may be adverse reactions in the form of allergies of various types. With prolonged admission, development of a fungal infection (candidiasis) may occur.

Also one of the side effects is the impact on the joints and tendons. Under the influence of nolicin, their inflammation occurs. Also often they lose elasticity, become brittle, easily tear, are exposed to inflammations, transformations. Therefore, nolitsin can not be taken by professional athletes, as well as those who engage in sports, has increased physical activity. Also significantly reduces the concentration of attention.

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Overdose

In case of an overdose, the main signs of poisoning are observed: headache, dizziness, nausea, vomiting, digestive disorders, epigastric pain, blurred vision, and sometimes loss of consciousness. In case of an overdose, the injured person should give urgent help as soon as possible and call an ambulance. At the first signs of poisoning, it is necessary to induce vomiting, which will cleanse the digestive tract, and prevent further absorption of the drug. Then the doctor will provide the necessary assistance and offer hospitalization.

 Usually in a hospital, gastric lavage is performed, neutralization of the poison further recovery treatment. Do not forget to tell the doctor that you were taking  nolycin with cystitis, and he became the cause of poisoning. This will significantly speed up the diagnosis and the selection of the right treatment.

Interactions with other drugs

Firstly, the drug should not be combined with alcohol. This is due to the fact that nolitsin pretty quickly forms quite stable complexes with alcohol that enter the blood. It is quite difficult to get them out, they practically can not be neutralized. It is also known that nolycin and alcohol complexes have high toxicity. Also, when interacting with other drugs, in particular, topics that contain ethanol, weakness, disability can manifest itself. Sometimes there may be allergic reactions, up to anaphylactic shock.

Preparations for heartburn and dairy products can not be taken together with nolicin, since its activity decreases significantly from this, and absorption decreases. Also, the drug is not compatible with drugs against diabetes mellitus, in particular, with funds based on sulfanylurea, theophylline. Also, nolycin is contraindicated in conjunction with nitrofurans.

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Storage conditions

The drug is stored for no more than two years in unpacked form, in its original packaging at room temperature. The date of production must be indicated on the packaging.

Shelf life

The drug is suitable for 2 years from the date of manufacture, indicated on the package. And the printed form, without the original packaging, the drug can be stored for no more than three months.

Reviews

If you analyze the reviews, you can see that most patients note that nolycin is very effective in treating cystitis, and other diseases of the genitourinary system. In such treatment, there are drawbacks and dignities. So, the advantage is that the drug makes it possible to get rid of the disease completely, even from the residual phenomena. The risk of relapse is reduced to a minimum. In addition to the main action, it often has an additional effect on other organs and systems, in particular, it has a slight anti-inflammatory effect, and also affects the mycobacteria, chlamydia, and reketasia.

The disadvantages include the fact that the drug quite effectively eliminates any infection. But at the same time, the normal state of the microflora may be disturbed, as a result of which dysbacteriosis develops, and the amount of normal microflora decreases. This entails the development of a fungal infection, in particular. Candidiasis. Therefore, often it is necessary to use nolitsin together with antifungal drugs.

 Sometimes nolylic stimulates the immune system, thereby increasing the body's ability to resist infection. When taking nolicin, a person recovers much faster. It should also be noted that against the background of taking nolycin, there are almost no complications and cases of recurrent disease.

The disadvantage is that  nolitsin in cystitis is  prohibited for children. It can be appointed only from the age of 18, according to some sources - from 15 years. Also strictly prohibited for pregnant and lactating mothers.