Senadeksin

Senadexin has a laxative effect.

Indications Senadexin

It is used for such disorders:

• provoked by poor peristalsis and hypotonia of the colon of constipation;
• helps stabilize the stool with such violations as hemorrhoids with proctitis and anal fissures;
• constipation, having a spastic or atonic character (regardless of origin).

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Release form

Release of the medication is carried out in tablets, in an amount of 10 pieces inside the blister pack. The box contains 1 or 2 such packages.

[2]

Pharmacodynamics

The drug is made on a plant basis and has laxative properties, affecting the activity of the peristalsis of the colon.

Drug treatment is provided by anthra- and other glycosides that transit after passing the capsule into the stomach through the small intestine without being absorbed. Inside the colon, the anthroglycosides are cleaved under the influence of the intestinal microflora, transforming into active derivatives - anthrons and anthranoles, which irritate the intestinal receptors of the colon, thereby stimulating its peristalsis and accelerating the process of excretion of intestinal contents.

Senadecin prevents the absorption of water with electrolytes. Osmotic influence allows to increase the volume of fecal masses, as well as the force of the filling pressure, so that the stimulation of peristalsis improves.

The effect of the drug develops after a lapse of 6-11 hours. If the medicine is used for a long time, the intensity of the drug effect may decrease (due to a decrease in the potassium levels inside the blood).

Pharmacokinetics

Products of the metabolism of anthraglycosides, which are contained in Senna, are practically not absorbed. Their excretion mainly occurs with feces, and a smaller part of the substance is excreted in the urine. In addition, the drug is excreted with sweat, and can also (in small amounts) pass into the mother's milk.

Dosing and administration

The drug should be consumed inside, in the morning or in the evening, washing down the pill with plain water.

For adolescents (at the age of 12 years) prescribing the drug in a dose of 2 tablets one or two times a day. The maximum allowable size of a daily dose is 4 tablets.

Elderly people should begin treatment with the use of the 1st pill per day.

Use Senadexin during pregnancy

Senadecin is not allowed for lactation or pregnancy.

Contraindications

The main contraindications:

• nausea with vomiting, as well as inflammation in the gastrointestinal tract, having acute shape (such as regional enteritis and colitis);
• presence of allergy in relation to elements of drugs;
• blockage of the intestine, constipation of a spastic character, a hernia of the restrained type, cystitis and bleeding in the gastrointestinal tract or uterus;
• not diagnosed diseases in the digestive system, which developed in connection with intestinal disorders in acute form or by surgical operations (appendicitis with peritonitis, as well as diarrhea and diverticulitis);
• pain sensations in the epigastrium, having an unknown nature;
• disorders of water-electrolyte balance, having a pronounced form;
• disorders of the liver function, having an organic nature;
• pains of a spastic nature;
• rectal hemorrhages.

Side effects Senadexin

Adverse symptoms are reversible and quickly go away when the drug is withdrawn or its portion is reduced. Among the reactions:

• digestive disorders: diarrhea, anorexia, vomiting, bloating, abdominal pain, colic, nausea, intestinal pseudomelanosis, and besides intestinal atony, digestive disorders and weight loss;
• problems in the work of the urogenital system: hematuria or proteinuria, as well as a change in the shade of urine;
• disorders of metabolic processes: loss of electrolytes, which can lead to problems with the work of the heart, weakness in the muscles, cramps, fatigue and collapse;
• immune lesions: urticaria, rashes, exanthema of local or generalized nature, and itching.

Overdose

Symptoms of poisoning: the appearance of intestinal colic, seizures, nausea, pain in the epigastric region, as well as diarrhea. Together with this, vascular collapse, an electrolyte balance disorder or intestinal function develops, and in addition a metabolic form of acidosis.

To clean up the disorder, you need to do a gastric lavage and conduct symptomatic procedures. If necessary, rehydration is performed (to fill the volume of the lost liquid).

Interactions with other drugs

The combination with quinidine sulfate can cause a decrease in the level of active elements in the blood.

Combination of the drug with SG can lead to the development of cardiac arrhythmias (in connection with the occurrence of hypokalemia).

Simultaneous use with antiarrhythmic drugs, diuretics and corticosteroids can trigger the development of muscle weakness.

Long-term use of Senadixin or its administration in large portions negatively affects the absorption of tetracyclines.

The drug weakens the therapeutic effect of drugs that have a slow absorption.

[3], [4]

Storage conditions

Senadecin should be kept out of the reach of small children. The temperature is within 25 ° C.

[5],

Shelf life

Senadixin can be used for 3 years from the date of manufacture of the therapeutic agent.

Application for children

Do not prescribe the drug to children who are under 12 years of age.

[6]

Analogues

The analogues of the drug are Xen preparations, Slabilen, Fibralax with Senadex, Senadé and licorice syrup, RectActiv, glycerin suppositories, Lactulose with Guttalax, and in addition Norgalax with Dufalac and Laxatin with Bisacodil.

Reviews

Senadexin receives a large number of positive reviews regarding its high drug efficacy.

Of the minuses most often identify the presence of addiction to the drug and a sufficiently large number of possible side effects.