Paralen

Paralene is a preparation with antipyretic and analgesic properties.

Indications of the paralena

It is used to treat headaches, including migraines, and in addition to pain in the back or muscles, dental pain, rheumatic pain, periodic female pain. Also on the list are the pains that occur with arthritis.

In addition, the drug helps to reduce fever and pain caused by flu or cold.

[1], [2], [3]

Release form

The release is carried out in tablets, 10 or 12 pieces inside a blister pack. The box contains 1-2 such packages.

Baby Parallel

Parabens baby is made in the form of an oral suspension, in glass bottles with a capacity of 100 ml. Inside the pack contains 1 bottle complete with a dispenser.

Paralen hot drink

Paralen hot drink is available in the form of a powder in a sachet, 5 grams each. The pack contains 5-6 or 10 or 12 such sachets.

Paralen combi

Paralene combi is made in the form of drops for oral administration, inside the bottle with a dropper of 25 ml. In the box there is one such bottle.

Paralene thyme

Paralene thyme is produced in pastilles, 10 pieces inside a blister plate. In the package there are 2 such plates.

Paralym of primrose thyme

Paralene of primrose thyme is a liquid for oral ingestion, in vials of 100 ml (or 130 g). Inside the pack - 1 bottle.

[4]

Pharmacodynamics

The mechanism of drug action is due to the suppression of activity of PG within the central nervous system. This type of oppression is selective.

Analgesic effect of paracetamol in the use of a single dose of medicinal dose of 500-1000 mg, lasts for 3-6 hours. The antipyretic effect lasts for 3-4 hours.

Pharmacokinetics

Paracetamol is absorbed almost completely and at high speed inside the gastrointestinal tract. The substance is quickly distributed inside liquids and tissues. Peak plasma values are noted after 0.5-1 hour after the use of the medication.

The medicine passes through the BBB and penetrates into the mother's milk with saliva. Paracetamol undergoes intensive biotransformation processes. Conjugation and oxidative reactions also develop, during which toxic products of metabolism of drugs are formed. When medication is administered in medicinal portions, hepatotoxic intermediates of metabolism at high speed are biotransformed with the participation of glutathione. In the process, mercapturic acid is formed, excreted mainly in the form of conjugates along with urine.

Less than 5% of the injected paracetamol is excreted unchanged. Half-life is within 1-3 hours. In people with liver failure in a severe degree, this period is extended to 5 hours.

With kidney failure, this period does not increase, but due to the fact that excretion of paracetamol occurs mainly with the help of kidneys, its dosage should be reduced.

Paracetamol is able to pass through the placenta and penetrate into the mother's milk.

[5]

Dosing and administration

The drug is used inside. For adolescents over 12 years of age and adults, the dosage is 1-2 tablets with a 4-time dose per day.

For children from the age group 6-12 years, the portion is 0.5-1 tablet with 3-4 times a day.

The gap between applications should be at least 4 hours. It is forbidden to use more than 8 tablets (4 g) of the drug over a period of 24 hours.

The length of the course of therapy is selected by the attending doctor. Without consulting him, you can use the medicine for a maximum of 3 days.

It is forbidden to exceed the dosage specified in the instructions, and also to combine Paralene with other drugs, which contain paracetamol.

[8]

Use of the paralena during pregnancy

Appointment Paralen in pregnancy is allowed only in situations where the possible benefits of taking it for a woman are more expected than the development of complications in the fetus.

Paracetamol is excreted with the mother's milk, but in non-essential quantities for the medicinal effect. The information available at the moment does not prescribe a ban on breastfeeding during treatment.

Contraindications

The main contraindications:

• the presence of high sensitivity with respect to the elements of the drug;
• deficiency of the G6FD component;
• anemia in severe or hemolytic form, blood diseases and non-hemolytic family jaundice;
• leukopenia;
• insufficiency of the liver or kidneys in severe degree;
• acute form of hepatitis, congenital hyperbilirubinemia;
• combination of drugs with hepatotoxic agents;
• alcoholism.

[6], [7]

Side effects of the paralena

The use of drugs can lead to the appearance of certain side-effects:

• immune disorders: the appearance of anaphylaxis and signs of intolerance, including pruritus and rash on the skin and mucous membranes (often erythematous or generalized and urticaria), and in addition, MEA (also Stevens-Johnson syndrome), edema Quincke and TEN;
• disorders of the digestive function: the development of epigastric pain or nausea;
• manifestations affecting the endocrine system: the emergence of hypoglycemia, which can lead to the development of hypoglycemic coma;
• symptoms of the lymph and blood-forming processes: the development of agranulocytosis, anemia (also its hemolytic form), thrombocytopenia, as well as sulfemoglobinemia with methemoglobinemia (pain in the heart, cyanosis and dyspnea) and the appearance of bruises or bleeding;
• disorders affecting respiratory processes: bronchial spasms in patients with intolerance to aspirin or other NSAIDs;
• problems with digestive activity: a violation of liver function, an increase in the activity of liver enzymes (jaundice does not usually develop).

Overdose

Manifestations of intoxication: pallor of the epidermis, deterioration of appetite and vomiting with nausea. In addition, the development of hepatonecrosis begins (the degree of expression of such necrosis is determined by the degree of drug poisoning), the activity of liver transaminases and PTV values increases. After 1-6 days, there is a noticeable clinical picture of hepatic failure.

To eliminate the disorders, it is necessary to introduce SH-category donors, as well as predecessors of glutathione-methionine binding (8-9 hours after poisoning), and also N-acetylcysteine (after 12 hours). To prevent the development of late hepatotoxic effect, perform gastric lavage.

[9]

Interactions with other drugs

The drug potentiates the medicinal effect of MAOI.

Weaken the properties of uricosuric drugs.

Caffeine helps to accelerate the absorption of ergotamine.

Paracetamol increases the excretion period of chloramphenicol element by 5 times.

Used for a long time, paracetamol is able to potentiate the therapeutic properties of anticoagulants (dicoumarin derivatives).

Combination of the drug with ethyl alcohol increases the likelihood of hepatotoxic effects and the development of acute forms of pancreatitis.

Phenytoin with rifampicin, and in addition barbiturates with phenylbutazone, ethyl alcohol, tricyclics and other stimulants of microsome oxidation increase the production of hydroxylated active degradation products of LS, as a result of which severe poisoning can develop even with slight overdoses.

Drugs that slow down the processes of microsomal oxidation (such as cimetidine), reduce the likelihood of the appearance of hepatotoxic effects.

Domperidone with metoclopramide is enhanced, and colestyramine, on the contrary, weakens absorption.

[10], [11], [12]

Storage conditions

Paralyn needs to be kept in a place that is closed from children's access. Temperatures are a maximum of 25 ° C.

Shelf life

Paralene can be used for 3 years from the date of manufacture of the therapeutic agent.

Application for children

The medication can not be used for children under the age of 6 years, and also with a weight less than 20 kg.

[13]

Analogues

Analogues of the drug are such drugs as Resistol, Minolexin, Gripp-Heel with Ambroxol, and in addition Inspirone, Pulmobrez, Ecoclave and Umkalor with Eucumbal, Pertussin, Langes and Tussrem Plus. The list also includes a liquorice syrup.

[14], [15]

Reviews

Paralen helps to quickly reduce the manifestations of the common cold and facilitate the coughing process. Feedback indicates that the medicine is highly effective.