Cefamabol

Cefamabol belongs to the category of cephalosporins and other related medicinal elements.

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Indications of the cefamabol

It is used to eliminate diseases that have an infectious and inflammatory origin, and are caused by bacterial pathogens that are sensitive to the action of drugs. Among them are:

• meningitis with sepsis and endocarditis;
• infections in the abdominal area;
• Gynecological infections;
• infectious processes affecting the urinary tract;
• joint or bone infections;
• infections in the soft tissue area;
• respiratory infections.

The medicine is also used to prevent the emergence of complications of an infectious nature after surgical procedures.

Release form

The release takes place in the form of lyophilizate, intended for the preparation of an injectable medical solution.

Pharmacodynamics

The medicine has a wide range of antibacterial activity. It has the ability to inhibit transpeptidase and disrupt the biosynthesis of the mukopeptidicletic bacterial wall. It has bactericidal properties.

It has an effect on a variety of gram-negative and gram-positive bacteria: Klebsiella, Escherichia coli, enterobacteria (in the treatment they can acquire resistance), Influenza sticks, Proteus mirabilis, Providence Rettgera, and Morgan bacteria.

In addition, it affects individual strains of vulgar protein, staphylococcus aureus (this includes most strains resistant to methicillin and strains producing penicillinase), streptococci, epidermal staphylococci and anaerobes of gram-positive or gram-negative nature (peptostreptococci, bacteroides, peptococci, clostridia and Fusobacterium spp .).

Pharmacokinetics

With an intravenous injection (in a dose of 0.5 or 1 g), the peak values of the drug are observed after a lapse of 0.5-2 hours and are 13 or 25 μg / ml, respectively. After intravenous injection (in a dose of 1.2 or 3 g) after 10 minutes, the drug value within the plasma reaches 139, 240 and 533 μg / ml (medicinal values of LS remain for 6 hours ).

The half-life of the substance with iv injection is 32 minutes; with an i / n prick this indicator is 1 hour. Drug values of the drug are formed inside the bones, joint and pleural fluids, and also in bile.

Excretion of the unchanged element occurs in the urine (in the 8-hour period, 65-85% of the drug is excreted at the same time). With a / m injection of 0.5 and 1 g of drugs, its level inside the urine is 254, as well as 1357 μg / ml, and after performing intravenous injection in portions 1 or 2 g - 750 or 1380 μg / ml, respectively.

If the kidney is deficient, the patient experiences a slowing of the excretion of Cefamabol.

Dosing and administration

The medicine can be injected in / in and / m method. When intramuscular injections need to dissolve 1 g of the drug in injection water or a solution of sodium chloride (3 ml).

In the case of a jet type of intravenous injection, the drug should be diluted in a ratio of 1 g of drugs per 10 ml of injection water or a solution of sodium chloride.

With IV in the dropper, the substance diluted according to the above description must be mixed with a 10% solution of glucose (NaCl solution can also be used).

The drug is prescribed in portions of 0.5-1 g, with intervals between administration of 4-8 hours.

To eliminate diseases in the field of the urethra, enter 0.5 g (in severe cases of pathology - 1 g) at intervals of 8 hours. For infectious lesions, life-threatening - enter up to 2 g at intervals of 4 hours (12 g per day).

The sizes of children's dosages are 50-100 mg / kg (if there is a severe degree of infection - increase to 150 mg / kg) per day with intervals between procedures of 4-8 hours.

To eliminate infections that were provoked by β-hemolytic streptococcus, it is necessary to continue therapy for a minimum of 10 days.

People who undergo hemodialysis procedures need to administer 1 g of drugs intravenously or intravenously at intervals of 12 hours (with an additional injection of a third or half of the dose after hemodialysis).

To prevent the development of infection after surgery, it is necessary to inject 1-2 g (adult) or 50-100 mg / kg (child) of the drug 0.5-1 hour before the procedure. Further, the same dosages should be administered within 24-48 hours.

People who have problems in the work of the kidneys, the dosage regimen is selected taking into account the QC indices. After the introduction of the initial dose of 1-2 g (determined by the severity of the infection process), the following maintenance doses are prescribed:

• level of CK 50-80 ml / minute - in severe stages of the disease, administer 2 g of drugs at intervals of 4 hours; at moderate stages of pathology - 1.5 g at intervals of 6 hours or 2 g at intervals of 8 hours;
• QC value of 25-50 ml / minute - in severe stages of pathology, administer 1.5 g of the drug at intervals of 4 hours or 2 g at intervals of 6 hours; at moderate stages of the disease - 1.5 g LS at intervals of 8 hours;
• KK value of 10-25 ml / minute - for severe forms of disease, 1 g is administered at intervals of 6 hours or 1.25 g at intervals of 8 hours; at moderate pathologies - 1 g with interruptions at 8 hours;
• SC level 2-10 ml / minute - in severe stages of the disease, administer 670 mg LS at intervals of 8 hours or 1 g at intervals of 12 hours; at moderate stages of the disease - 0.5 g with interruptions of 8 hours or 0.75 g at intervals of 12 hours;
• the QC value is less than 2 ml / minute - in case of severe stages of the pathology, administer 0.5 g of drugs with interruptions of 8 hours or 0.75 g with interruptions equal to 12 hours; for moderate infections - 0.5 g of LS at intervals of 12 hours.

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Use of the cefamabol during pregnancy

Pregnant and lactating mothers are prescribed medicine only in extreme cases. In this case, it is necessary to take into account the ratio of benefits for women and the risk of negative consequences for the fetus / infant.

Contraindications

The main contraindication is the presence of intolerance to penicillins along with cephalosporins and carbapenems.

Side effects of the cefamabol

Taking medication can lead to the development of the following side effects:

• the emergence of colitis pseudomembranous nature, persistent form of hepatitis and intrahepatic cholestasis, and in addition vomiting or nausea;
• the appearance of thrombocyto-, leuko- or neutropenia, a positive Coombs reaction, a decrease in the values of CC, an increase in the level of urea nitrogen inside the blood (in persons with kidney deficiency), and in addition a temporary increase in the activity of liver transaminases and SF parameters, the development of superinfection or dysbiosis;
• signs of allergy: urticaria, fever, rashes, eosinophilia. Occasionally angioneurotic edema, bronchospasm and anaphylaxis are noted;
• pain and the appearance of infiltration at the site of administration, as well as the development of thrombophlebitis (with iv injection).

Overdose

When using Cefamabol in too high a dosage, convulsions may develop.

To eliminate the violation, you need to stop the injection of drugs, and then appoint the patient to take anticonvulsants. Together with this, it is required to perform the hemodialysis procedure.

Interactions with other drugs

The drug potentiates nephrotoxic properties of loop diuretic substances, and at the same time aminoglycosides. In addition, prolongs the effect of alcohol (causes the development of a disulfiram-like reaction).

When combined with aminogligozidami increases the antibacterial effect of drugs.

Probenecid inhibits the excretion of the drug, doubling the level of concentration and the duration of the therapeutic effect.

Thrombolytics, as well as anticoagulants and NSAIDs increase the likelihood of bleeding in the patient.

Has a pharmaceutical incompatibility with aminoglycoside solutions (it is forbidden to mix them inside a single syringe).

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Storage conditions

Cefamabol is contained in a dark, completely protected from moisture, a place with a child's access closed. Temperature values are not higher than 25 ° C.

Shelf life

Cefamabol can be used for 2 years from the date of manufacture of the drug.

The finished solution has a shelf life of 24 hours (subject to a temperature of up to 25 ^° C), and also 96 hours if stored in a refrigerator.