Panthitrate

Pancidrate helps to fill the lack of pancreatic enzymes.

Indications of the pancicrate

It is used in such situations:

• for substitution treatment for chronic pancreatitis, for dyspepsia, gastrocardial syndrome, cystic fibrosis, pancreatectomy, non-infectious diarrhea and bloating, and after irradiation procedures;
• at disorders of processes of assimilation of food products after the procedure of resection in the area of the stomach or some part of the small intestine;
• to improve the digestive process with malnutrition, sedentary lifestyle, problems with chewing activity, or after being in a state of prolonged immobility.

In addition, Pancetrate is used during the procedures of instrumental examination of the peritoneal organs (X-ray or ultrasound).

Release form

The release is carried out in gelatin capsules, placed in flasks of polyethylene or glass. Each bottle can contain 20, 50 or 100 capsules.

Pharmacodynamics

The drug helps to compensate for pancreatic activity, in which there is a deficit of secretion. The drug has a proteolytic, lipolytic, and also amylolytic effect. The effect of pancreatin enzymes leads to the breakdown of proteins, which in this case are converted into amino acids; starch, which turns into dextrins with monosaccharides; and fats, which decompose to glycerol with fatty acids.

Pancetrate stabilizes all digestive processes and helps to improve the activity of the digestive tract. Pancreatic enzymes are released from the capsules inside the small intestine, trapped in an alkaline medium. Avoid dissolution under the influence of gastric juice capsules helps their stable shell.

Pharmacokinetics

Entered into the stomach capsules are further mixed with the food used, and then evenly distributed inside the acidic stomach environment. During gastric passage, the acid-resistant capsule shell prevents the inactivation of pancreatic enzymes.

Moving together with food in the small intestine area, the capsules dissolve under the action of an alkaline medium, after which the enzymes begin to be released.

Dosing and administration

The medicine is used orally, with food or after it is taken. Capsule can not be chewed, you should swallow it and drink it with some liquid (plain water, fruit juice or warm tea). The size of the portion is determined by the severity of the digestive disorder. The average adult dose is 1-2 capsules with a volume of 10 thousand units or 1 capsule with a volume of 25 thousand units. Take them three times a day.

The duration of the course is prescribed for each person separately, taking into account the medicinal indications (for 3-5 days if there are errors in the diet regime or for 3-12 + months, if the patient needs constant substitution treatment).

[3]

Use of the pancicrate during pregnancy

Because clinical testing of the effects of pancreatic enzymes on the body of pregnant women has not been carried out, Pancitrat should be used with caution in this period. It is also not enough and the data of testing on animals with the study of the toxic effect of the substance on reproductive function and fertility.

Because there is no information on the systemic exposure of pancreatic enzymes, one should not expect the possibility of exposure to the infant, which the mother is breastfeeding. Therefore, the drug is allowed to use during lactation.

If necessary, nursing or pregnant women may consume pancreatin in servings that provide the required nutritional status.

Contraindications

The main contraindications:

• acute form of pancreatitis or chronic during the period of exacerbation;
• hypersensitivity to the elements of drugs;
• children age less than 6 years.

Side effects of the pancicrate

Basically, Pancidrate is transferred without complications. Only occasionally develop allergy symptoms, nausea, discomfort in the stomach, as well as diarrhea or constipation. As a result of prolonged intoxication, hyperuricosuria or hyperuricemia may develop. In cystic fibrosis, due to excess of the recommended portion, stricture inside the ascending colon can appear.

[1], [2]

Overdose

Intoxication with the drug can cause hyperuricosuria hyperuricemia or constipation.

Interactions with other drugs

The combination of Pancitrate with antacids containing calcium carbonate or magnesium hydroxide weakens the effectiveness of the substance pancreatin.

The use of drugs can reduce the absorption of iron, as well as folic acid.

[4]

Storage conditions

Panticrate is required to be kept in usual conditions for medicines. Temperature values should not be above 20 ° C.

[5]

Special instructions

Reviews

Pancidrat receives mostly positive reviews. It works perfectly after a lot of feasts (for example, during the holidays), helping to eliminate the disturbances associated with the digestion of food products and facilitating this process. Also, the drug is often prescribed for the treatment of pancreatitis in chronic form.

Shelf life

Pantcitrate is allowed to be used for 3 years from the date of release of the drug.