Sodium hydroxybutyrate

Sodium oxybutyrate has hypnotic, anesthetic, anxiolytic, and also antihypoxic properties.

[1], [2], [3], [4], [5], [6], [7], [8], [9], [10], [11]

Indications of the sodium oxybutyrate

It is used to eliminate the following disorders:

• pathologies of the neurotic type;
• glaucoma;
• problems with sleep;
• the psychoses arising after surgery;
• severe hypoxia.

Along with this, the medicine is used in surgery - as a means of introductory anesthesia in the performance of operations of a malignant type, while maintaining a respiratory process of a spontaneous type.

[12], [13], [14], [15]

Release form

The release takes place in the form of a lyophilizate, which is readily soluble in ethyl alcohol, as well as plain water. The powder is contained in ampoules with a volume of 5 or 10 ml. Inside the box - 5 or 10 ampoules of powder.

[16], [17]

Pharmacodynamics

Sodium oxybutyrate usually demonstrates interaction with different endings, affecting the activity of various channels, including the channels Ca2 + and K +. As a result, the release process of the activating conductors within the presynaptic receptors is suppressed. This leads to a postsynaptic deceleration. There is also a suppressive effect of the drug against HC.

In the case of small portions of drugs, an anxiolytic effect develops, the severity of neurotic disorders decreases, as well as individual vegetative manifestations in response to stress. There is also a hypnotic effect of the drug.

In high doses, the drug is used as a remedy for muscle relaxation and general anesthesia. At the same time, anticonvulsive, sedative and anti-shock effects develop. In this case, elements of nootropic action can also be observed.

With therapy, the general resistance of the body increases, and in addition the heart with the brain and other organs with respect to oxygen deficiency. There is also an improvement in microcirculation processes, an increase in glomerular filtration activity and stabilization of renal activity in case of blood loss.

It is revealed that the drug is able to pass through the histohematetic barriers.

[18], [19]

Dosing and administration

The drug is allowed to be used orally, and also used for in / m and / in injections.

If it is necessary to perform general anesthesia, the solution should be injected into the vein very slowly - a maximum of 1-2 ml / minute. If it is required to maintain anesthesia, the drug is administered additionally at a dose of 40 mg / kg. With introductory anesthesia, children are prescribed 100 mg / kg (a glucose solution is added to the drug, drip) for 5-10 minutes.

When the drug is administered in / m, the portion is 120-150 mg / kg.

Orally, adults need to take 100-200 mg / kg of the drug, and children - not more than 150 mg / kg.

[26], [27], [28], [29]

Use of the sodium oxybutyrate during pregnancy

It is forbidden to use sodium oxybutyrate during pregnancy (except for obstetric procedures only).

The medicine can not be used for lactation, because it has a hypnotic effect on the baby.

Contraindications

The main contraindications:

• hypokalemia;
• severe forms of toxicosis in pregnant women, against which there is a syndrome of increased pressure and hypokalemia;
• myasthenia gravis.

[20]

Side effects of the sodium oxybutyrate

It has been revealed that in the case of rapid intravenous injection of the solution, some side effects may appear: a disorder of the respiratory function, a feeling of psychomotor agitation, vomiting, a feeling of drowsiness, severe nausea, and hypokalemia in addition.

[21], [22], [23], [24], [25]

Overdose

As a result of drug poisoning, there may be a feeling of excitement, twitching of limbs, and sometimes a stopping of the respiratory process may be observed.

[30],

Interactions with other drugs

With the combination of sodium oxybutyrate with anesthetic and analgesic drugs, the properties of these drugs are often significantly enhanced.

[31], [32]

Storage conditions

Sodium oxybutyrate is kept in a dark place inaccessible to children. The temperature values are in the range of 15-25 ° C.

[33], [34]

Special instructions

Reviews

Sodium oxybutyrate is often discussed in a variety of forums dedicated to medicine. But at the same time, reviews about him are often little related to his medical impact - patients usually use it for completely different purposes.

For example, individual users report using the drug as a substitute for an alcoholic beverage. It is necessary to understand that this substance causes very fast addiction, which leads to complications, which are more powerful by their negative effects than the result of dependence on alcohol.

At the same time, patients ask a lot of questions related to the peculiarities of the use of the drug - about using the product on their own at home, about the place of purchase, and also about the dosage sizes for treating various disorders.

[35]

Shelf life

Sodium oxybutyrate is allowed to be used for 4.5 years after the release of the drug.

[36], [37], [38], [39]