Macmirror with giardiasis: treatment in adults and children

Among a number of microorganisms, whose growth is effectively inhibited by the active substance of this antibacterial drug (nifuratel), protozoa are also named. Among them - Giardia. Infection with these tiny parasites is quite common. Diagnosis is not always informative, besides there is no single tactic for the therapy of Giardiasis. Preparations capable of destroying parasites are quite toxic and have a number of side effects, one of which is hepatotoxicity. Strong immunity to infection after recovery does not arise. In addition, lamblias developed resistance to the often used for their eradication drugs, for example, metronidazole or furazolidone.

Often, the presence of lamblia is combined with fungal lesions (candidiasis) and the detection of Helicobacter pylori.

Therefore, the appearance of a new drug, suitable for eradication of lamblia, attracted the attention of physicians. Macmirror (nifuratel) is currently considered the drug of choice for giardiasis. Laboratory and clinical studies confirm its high efficiency in the performance of this task (more than 90%). In addition, in the presence of a combination of intestinal infections, which are often accompanied by giardiasis, it is not necessary to additionally prescribe other drugs, since this antibiotic has a wide range of antibacterial activity. Eliminated from the body through the urinary tract, he on the road makes them sanation.

And, perhaps, the main advantage of nifuratel is low toxicity (all antiparasitic drugs known to this day are very toxic), which is manifested by a minimal number of side effects.

For three decades of its use, no cases of the development of resistance of pathogenic microorganisms have been identified.

[1], [2]

Indications of the makmirora at a lambliasis

Inflammatory diseases of the genitourinary and digestive canal, the causative agents of which are sensitive to the active substance of the drug:

• High sensitivity is found in Giardia ( lamblia ), Trichomonas vaginalis, Entamoeba histolytica, Helicobacter and Papiliobacter pylori, Candida fungi, Salmonella (typhi, typhimurium, enteridis), Shigella (flexneri 2a, flexneri 6, sonnei), Enterococcus, Staphylococcus aureus, Escherichia coli and other enterobacteria;
• moderately sensitive Proteus (mirabilis and vulgaris), Prseudomonas aeruginosa.

[3], [4]

Release form

The drug is available in solid form of tablets coated with gastro-coated dragee shell. Contain 0.2 g of active substance - nifuratel.

Pharmacodynamics

The suppression of the development and growth of sensitive microorganisms by the active ingredient of the drug occurs through several routes of exposure.

First, Nifuratel inhibits the process of their cellular respiration: the molecules of the active substance attach to themselves oxygen molecules, creating its deficiency for microorganisms. In addition, Nifuratel inhibits the enzymatic activity of certain cellular respiratory enzymes.

Secondly, getting into the cells of the microorganism, the nitro group (NO2) is restored, and the obtained component turns out to be toxic for the cells of the pathogenic organism.

The combination of these actions leads to the death of aerobic microorganisms, in the same way - and candidal microflora.

Nifuratel as a representative of nitrofurans is able to block the synthesis of the DNA molecule of pathogenic organisms, and, to a lesser extent, suppress the replication of their RNA.

Pharmacokinetics

The drug, getting into the gastrointestinal tract, with good speed is distributed in the tissues of the body, easily overcomes blood-brain and placental barriers, is found in breast milk. Splitting into metabolites occurs mainly in the liver and tissues of muscle fibers. It is eliminated from the body in its entirety (about half of the drug is excreted unchanged) through the urinary tract, providing a disinfecting effect.

Dosing and administration

Macmirror with giardiasis in adults is dosed at 0.4 g (two tablets) twice or thrice a day. The recommended duration of treatment is a week. The medicine needs to be taken after a meal.

Macmirror with giardiasis in children is used from the age of six and dosed at a rate of 15 mg per kilogram of the weight of the child twice a day or 10 mg per kilogram of weight three times a day. Duration and method of use is similar.

Use of the makmirora at a lambliasis during pregnancy

The active substance of the drug easily overcomes the hematoplacental barrier and is found in breast milk. Therefore, although its teratogenic properties are not found, the appointment of pregnant and lactating women MacMyor is possible only in case of vital necessity and provided the baby is transferred to artificial feeding.

Contraindications

Known intolerance to the patient of any of the ingredients of the drug.

Renal insufficiency, degenerative-dystrophic changes of nerves, enzymatic deficiency G6FD.

Children under six years of age, although some sources do not specify age limits.

Side effects of the makmirora at a lambliasis

The most likely - bitterness in the mouth, diarrhea, nausea, very rarely - a more detailed picture of dyspeptic phenomena. Rarely enough - allergies in the form of rashes and itching, peripheral nerves neuropathy.

[5]

Overdose

Cases of exceeding the recommended dose are not known, hypothetically - increased side effects.

Interactions with other drugs

Potentiates the action of nystatin. Incompatible with alcohol-containing beverages and preparations (development of a disulfiram-like reaction is possible).

[6], [7]

Storage conditions

Store no more than five years in the original packaging, observing the temperature conditions up to 25 ℃. The storage of the drug should be out of reach for children.

Analogues

For the eradication of lamblia, other drugs can be used. The derivatives of nitroimidazole, in particular - metronidazole, took a long time leading position in the treatment of this disease. Currently, this drug and its synonyms (Trichopolum, Clion and others) are not recommended for lambliasis, since parasites have already lost sensitivity to this drug. Other drugs from this group, for example, Ornidazole, are effective in about 90% of cases. However, the incidence of side effects in Ornidazole is estimated at 15% versus 2% for Macmoror.

Modern anthelminthic drug Nemozol (albendazole) - is universal. It acts on all known types of worms at any stage of development (from eggs to mature individuals). The drug is also active for Giardia. The splitting of Nemosol into metabolites occurs in the liver. Therefore, the frequency and the number of side effects of this drug is higher. The answer to the question of which drug to choose - Nemozol or McMiore with giardiasis depends on many factors. First, on the patient's age. Nemozol has been used since the age of six, McMiore's application has been allowed by some authors since two months. Secondly, possible possible concomitant infections should be considered. If lamblia is found in combination with bacterial infections, then the choice is MacMyor. If, in addition to infection with lamblias, the patient finds pinworm or ascaris, then the drug of choice in this case will be Nemozol. The choice of treatment regimen and suitable drugs should remain with a specialist who will take into account the individual specificity of the disease.

If we are talking only about infection with lamblia, then Macmirror is currently the most suitable drug for their destruction, both in terms of effectiveness and safety for adults and children. Although usually in the schemes of lamblia eradication two courses of different drugs are used, each of which is active in relation to these parasites.

Reviews

Doctors unanimously assert that McMiore is the most suitable modern effective and safe drug for the treatment of Giardiasis (according to research in Switzerland - 97% of patients have been cured). However, he did not help three percent of the participants in the study.

The patients' opinions, as always polar, are very satisfied, their children got rid of lamblias, while other drugs did not help. But many adults complain of side effects not indicated in the instructions: severe nausea, vomiting, headache, constipation (rather than diarrhea), severe palpitation, vision problems. Although it is not known whether they took into account the interaction of the drug with alcohol during the treatment.

Macmirolog at a lambliasis preparation, certainly, quite good, only can to someone and to not approach or suit. Older drugs have many side effects, they are toxic and change the formula of blood, although after the cessation of admission it is restored. Our relationship with any drugs is very individual, so it's better to complain about side effects to the doctor in charge and look for a suitable treatment scheme with him.