Femoston with menopause: how to take and what to replace

The climacteric period in women is caused by a decrease in the production of sex hormones by the ovaries. This process, as a rule, is accompanied by poor health, tides, excessive sweating, irritability, insomnia, malfunctions of the heart, hypertension, weight gain and other troubles. To avoid or weaken the manifestations of menopause take hormonal drugs. Femoston with menopause is one of the most effective hormonal drugs often prescribed by doctors.

[1], [2], [3], [4]

Indications of the femostone with menopause

Indications for the use of femostone in menopause are its negative manifestations. This is a two-component preparation consisting of estradiol, the most active sex hormone of a woman and dydrogesterone, a steroid hormone that takes part in the regulation of vital processes.

With the help of femostone, hormone replacement therapy is performed for various disorders caused by natural or premature artificial menopause, which leads to a decrease in the synthesis of estrogens. Also, the drug is indicated for the prevention of osteoporosis and women with a high risk of fractures, if special medications for treating these ailments are for any reason contraindicated or intolerable.

[5], [6],

Release form

The form of release of femostone is tablets in various dosages, as indicated by the inscription in the form of a fraction: 1/5, 1/10, 2/10. The numerator of the fraction indicates the content of estradiol in one tablet of the drug in milligrams, and the denominator for the content of dydrogesterone. In addition, such auxiliary components as colloidal silicon dioxide, corn starch, lactose monohydrate, magnesium stearate, shell material, etc. Are used in the manufacture of femostone. Femoston is packed in a blister of 28 tablets of two colors with the days of the week indicated on them. The side of the package with tablets for the first two weeks of admission is marked with the number 1, the rest - 2.

Pharmacodynamics

Estradiol, which is the active substance of femostone, is analogous to its chemical and biological characteristics of the hormone produced by the body naturally. Therefore, the pharmacodynamics of the drug consists in replenishing the lack of sex hormones caused by the extinction of ovarian function during menopause. This provides treatment for hot flushes, hyperhidrosis, anxiety, dizziness, insomnia, headaches, atrophy of the mucous genital organs and urinary system.

Also, the drug increases the elasticity and tone of the muscles of the genital organs, sphincters of the bladder. Dydrogesterone, as a component of femostone, provides a normal structure of the endometrium, prevents its pathological proliferation. It is an effective preventive tool for osteoporosis and bone fractures, inhibits the reduction of bone mass.

Pharmacokinetics

The pharmacokinetics of femostone testifies that as a medicine for low-dose hormone replacement therapy, the drug, getting inside, is quickly absorbed. As a result of metabolic processes, estradiol, which is an integral component of femostone, is converted into a liver in estrone sulfate and estrone (a natural estrogen produced by cholesterol). In this case, the level of total cholesterol and "bad" (low density) decreases, and "useful" (high density) increases. From the body, estradiol is excreted mainly by the kidneys. Dydrogesterone - the second component, is quickly absorbed by the gastrointestinal tract, concentrating in the body as much as possible after 0.5-2.5 hours after ingestion. Completely excreted by the kidneys after three days.

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Dosing and administration

The way of application and dose of femostone in menopause depends on the phase of menopause, the condition of the patient and is determined by the attending physician. Femoston 1/10 is appointed in perimenopause, its reception is designed for a cycle of 28 days. In the first 14 days, one white tablet (estradiol content - 1 mg) is taken daily at the same time. In the next 2 weeks of the cycle, you should drink a tablet of gray color (estradiol - 1 mg and dydrogesterone - 10 mg) in the same scheme.

Femoston 2/10 should be drunk two weeks on a pink pill (2 mg of estradiol), in the following days - one yellow-orange (2 mg of estradiol and 10 mg of dydrogesterone). Women who still have menstruation should begin treatment with the drug on the first day of menstruation. If the menstrual periods are irregular, then at first it is necessary to treat 2 weeks with gestagen, and then switch to femostone. Femoston 1/5 is prescribed to women who are in postmenopause, lasting a year or more, taking a pill a day at the same time.

[9],

Femoston 2/10 with menopause

Femoston 2/10 is indicated in the early menopause as a hormone replacement therapy. The active substance of the drug is estradiol, very close to the hormone produced by the ovary. The pharmacological properties of the drug include regulation of the functions of the genital organs, stabilization of metabolic processes in the bone and the autonomic nervous system. Dydrogesterone contained in the preparation provides delamination of the endometrium, which significantly reduces the possibility of endometriosis and uterine cancer. The drug is contraindicated in breast cancer, endometriosis and other neoplasms. It is not prescribed for liver diseases, uterine bleeding and, of course, for pregnant women and nursing mothers. Treatment with femostone 2/10 may be accompanied by pain in the chest, rarely dizziness, nausea.

Femoston 1/10 with menopause

Usually, hormone replacement therapy is started with one gram of estradiol, therefore initially 1/10 of femostone is prescribed. According to the characteristics, it is similar to femostone 2/10, differs only in the dose of estradiol. As the treatment progresses, the doctor can adjust the dose of admission by increasing it. Tablets are consumed regardless of food intake, once a day, adhering to the same time. If, for some reason, the drug is missed, then the double dose to make up for lost time should not be taken.

How to replace femoston 1/10 with menopause?

The standard procedure for hormone replacement therapy lasts 5-7 years. After 2-3 years of taking Femoston 1/10, the dose can be reduced by going to 1/5. One blister of tablets is designed for one cycle of reception. Interrupts between the cycles do not need. Throughout the treatment it is necessary to observe the condition of the genitals, mammary glands, thyroid gland, and other organs. Therapy may continue until the risk of complications exceeds the therapeutic effect of the treatment. The effect of the drug on women after age 65 has not been studied.

Contraindications

Femoston has a number of significant contraindications to the use, so before his appointment it is necessary to undergo a series of examinations, both general and the gynecologist. When identifying pathologies that may worsen from taking Femoston, the doctor must decide on the appropriateness of his appointment.

Contraindications to use are pregnancy, breast-feeding of the child, intolerance of the components of the drug, as well as a number of diseases. Such diseases include uterine bleeding, untreated endometrial hyperplasia, malignant neoplasms of the breast, acute blockage of veins, kidney disease. It is also necessary to be cautious when prescribing the drug to patients suffering from diabetes mellitus, epilepsy, migraines, high blood pressure, otosclerosis, uterine myoma, gallstone disease, systemic lupus erythematosus, renal insufficiency, bronchial asthma.

A serious risk factor for the appointment of femostone is obesity. With the predominance of the use of femostone before the risk of complications, it is necessary to stay under the supervision of the doctor and when the first symptoms of the described diseases appear (severe headache, high blood pressure, yellowing of the skin, etc.), discontinue treatment. When receiving extensive injuries and the need for surgical interventions, you should also stop taking hormones.

Side effects of the femostone with menopause

Possible side effects of femostone with menopause. In 1% to 10% of women participating in the drug test, there were headaches, flatulence, nausea, abdominal pain, pelvis and mammary glands, leg cramps. Less than 1% experienced depression, irritability, allergies, edema of the extremities, an increase in the size of the existing fibroids, an exacerbation of cholecystitis.

A small proportion of women (less than 0.1%) observed swelling of the mammary glands, malaise, asthenia, jaundice. And in a very insignificant group (0.01%) there were such manifestations as epileptic jaundice, vomiting, skin lesions, myocardial infarction, stroke. Therefore, when treating with femostone, the patient should be under the constant supervision of a doctor, undergoing periodic examinations, doing mammography, examining the liver, the thyroid gland, monitoring the level of sugar in the blood. If the slightest deviation is detected, the patient's attention should be emphasized and directed to the profile doctor, if necessary, discontinue treatment.

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Overdose

Femoston belongs to low-toxic drugs. In practice, there were no cases of an overdose of femostone. Theoretically, nausea, vomiting, dizziness, drowsiness can be observed. In case of an alleged overdose, treatment can be directed at eliminating these symptoms.

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Interactions with other drugs

When studying interactions with other drugs, it was noted that simultaneous reception of femostone with drugs that activate liver enzymes reduces the concentration of the drug, thereby weakening the effect of estrogens. These drugs include carbamazepine, phenytoin, rifabutin, barbiturates, rifampicin. Phytopreparations containing St. John's wort, on the contrary, enhance the effect of femostone. In turn, femoston is able to affect such drugs as theophylline, fentanyl, tacrolimus, cyclosporine. Their joint reception can increase the level of concentration of the latter to toxic, so it is advisable to lower their dose of admission.

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Storage conditions

The conditions for storing femoston must conform to the usual standards: a darkened dry place with an air temperature not exceeding 25 degrees Celsius, outside the reach of children.

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Shelf life

Shelf life - 3 years.