Dexapos

Eye drops Dexapos is a drug based on the corticosteroid hormone dexamethasone. Drops effectively stop the inflammatory process, and also help with severe allergic eye damage.

Indications Dexapos

Dexapos is successfully used in ophthalmic practice for the treatment of complex inflammatory, allergic and non-infectious ocular pathologies with affection of the conjunctiva, cornea,

 Destination Dexapos is appropriate:

• with conjunctivitis of infectious and allergic genesis;
• when sclerite;
• with a deep form of keratitis without damage to the epithelial tissue;
• with iritium and iridocyclitis;
• with choroiditis, retinitis;
• with ophthalmia;
• at allergic processes;
• with hay fever;
• for the prevention and treatment of inflammation after surgery or trauma.

Release form

Dexapos is a drop for eye use. The solution does not have a specific color, it is transparent. Active component is dexamethasone - a glucocorticosteroid hormone substance.

Dexapos is dispensed in plastic bottles-droppers of 5 ml. Each bottle has its own packaging of cardboard, with a nested instruction for use.

Pharmacodynamics

The active ingredient dexamethasone, which is a part of the drops of Dexapos, provides a strong anti-inflammatory effect. The effect of the drug with topical application was proved after the successful treatment of inflammatory and allergic processes in the anterior ocular segment. In the postoperative period, Dexapos is used as a preventive and medicinal agent for possible inflammation of the eye.

The specificity of the curative effect of a corticosteroid substance has not been definitively determined at this time. Binding to protein intracellular receptors affects the metabolic processes at the gene level. In addition, the protein structures necessary for chemotaxis and immune responses are inhibited.

Also, corticosteroid hormones affect the state of humoral and cellular immunity, provoking the appearance of monocytopenia and lymphocytopenia.

Pharmacokinetics

A few studies indicate that in the local application of such drops as Dexapos, therapeutic concentrations of the active substance dexamethasone can be detected in the tissues. At the moment when a small amount of the active ingredient appears in the intact epithelial layer of the cornea, in the presence of an inflammatory process or damage to the cornea, the penetration increases.

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Dosing and administration

Drops of Dexapos are used in ophthalmology, dropping 1 drop of the drug into the conjunctival sac of the diseased eye organ, up to 5 times a day. In complicated and severe pathological situations, the doctor may prescribe a different dosage and frequency of application of Dexapos.

In standard situations, the duration of treatment with drops is 14 days. In this case, if the effect of treatment is not detected during the first 48 hours from the first use of the drug, the doctor can cancel Dexapos, replacing it with another drug.

Applying eye drops, it is necessary to observe the rules of hygiene and not to allow contact of the droplet of the bottle with skin and mucous membranes.

Children's dosages for the drug Dexapos are not provided, as there are no reliable studies on the use of eye drops in children's practice.

[4], [5]

Use Dexapos during pregnancy

Full-scale and full-scale studies on the possibility of using drops of dexapos in pregnant and lactating women were not conducted. For this reason, it is not recommended to expose pregnancy and fetal health to unreasonable risk.

Dexapos can only be prescribed by a doctor solely for life reasons.

Contraindications

Dexapos is not recommended for use:

• in reactions of hypersensitivity to the ingredients of the drug;
• with viral, mycobacterial and fungal lesions of the eye;
• with traumatic and ulcerative lesions of the cornea;
• with increased intraocular pressure;
• with immunosuppression.

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Side effects Dexapos

In some cases, the use of Dexapos may be accompanied by such adverse symptoms:

• local reddening, transient burning, itching, sensation of foreign body in the eye organ, sensation of "fog" before the eyes;
• increased intraocular pressure, cataract, transient accommodation disorder, acute anterior uveitis, erosive and perforating processes in the cornea, eyelid drooping, delayed healing of the postoperative wound;
• exacerbation of existing infectious pathologies of the eye, attachment of a fungal infection.

[3]

Overdose

The situation with the appearance of signs of intoxication with the use of large dosages of Dexapos was not described.

However, if a possible overdose occurs, wash your eyes with running warm water.

If an overdose of Dexapos could be caused by prolonged use of drops, then significant side effects may occur - for example, the development of the Itenko-Cushing syndrome. Symptoms of acute poisoning with Dexapos were not observed in any of the cases.

Interactions with other drugs

Specific studies on drug interactions Dexapos and other medications have not been conducted.

However, the combination of dexapos with atropine, mydriatica and anticholinergic drugs should be avoided - this combination can lead to increased intraocular pressure.

If the patient is prescribed the use of other eye preparations, the interval between their application should be maintained - about 15 minutes. In this case, the eye ointment should be applied last.

[6], [7]

Storage conditions

Dexapos can be stored at room temperature, in factory packaging, in a place inaccessible to children.

Shelf life

Dexapos stored up to 2 years in a packaged form. After the opening of the Dexapos dropper, the shelf life of the drug is shortened to 1 month.