Ajikold

For the rapid treatment of colds there are many drugs. Adjikold refers to the most effective means, we will consider his instruction.

Adjikold is a locally irritating drug used for the symptomatic treatment of colds and rheumatic back pain. It has analgesic and antipyretic properties. It has several forms of release, which allows you to assign it to patients of different age groups.

The composition of the medicament includes several active components: paracetamol, phenylephrine hydrochloride, ascorbic acid. Their combined effect on the body normalizes the general well-being of respiratory pathologies.

Indications Ajikold

The main indications for use of Adjikold are the treatment and prevention of colds. The drug helps with headaches, nasal congestion and runny nose, muscle and joint pains, as well as with fever and chills.

Release form

The cold remedy has several forms of release:

• Ointment for external use
• Powder for solution
• Pills
• Vegetable syrup

Each of them contains: paracetamol, phenylephrine hydrochloride, ascorbic acid, caffeine and auxiliary substances. The choice of dosage form depends on the age of the patient and the symptoms of the common cold. 

Agicold Ointment

An effective local irritant with anti-cold properties is Adzikold ointment. It includes such substances: camphor 70 mg, menthol racemic 60 mg, essential oil of eucalyptus 30 mg and thymol 15 mg. Produced in plastic containers of 20 grams, which are packed in cardboard packs.

• Indications for use: infectious and inflammatory diseases of the lower and upper respiratory tract, which are accompanied by a cough, runny nose, nasal congestion. Muscle and joint pain, neuralgia.
• The product is intended for external use only. With a cold, a small amount of ointment should be applied 2 times a day to the chest, neck, and back, vigorously rubbing. With neuralgia and muscle pain, ointment is applied to the painful areas. After rubbing, the treated areas must be wrapped. To eliminate rhinitis 1 spoon of ointment should be dissolved in 250 ml of hot water and use inhalation agent 2 times a day.
• Side effects occur when individual components of the drug are intolerant. This manifests itself in the form of allergic reactions, including contact dermatitis. If you accidentally take the medicine inside, you may experience attacks of nausea and vomiting, diarrhea, and increased drowsiness.
• Contraindications: age of patients younger than 2 years, tendency to bronchospasm, convulsions, damage to the skin at the site of application, hypersensitivity to the components of the ointment. With special care, the drug is prescribed during pregnancy and lactation. It is forbidden to treat mucous membranes, especially the oral cavity and nose.
• Overdose with external application does not occur. If the medicine has got inside, it provokes nausea, vomiting, headaches and discomfort in the abdomen, severe dizziness and redness of the face, convulsions, CNS depression, shortness of breath. To eliminate these reactions, it is necessary to rinse the stomach, take activated charcoal or salt laxative. With severe convulsions, intravenous diazepam or short-acting barbiturates are recommended.

Agicold vegetable syrup

Combined drug used for colds and coughs is Agicold vegetable syrup. The effectiveness of the drug is due to its composition. The syrup has mucolytic properties, that is, it helps to dilute and sputum, reduces swelling and flushing of the mucous throat, facilitates breathing, reduces bronchospasm.

• Indications for use: symptomatic and complex therapy of inflammatory diseases of the respiratory tract with a cough (pharyngitis, tracheitis, bronchitis, laryngitis, pneumonia). The main contraindication is hypersensitivity to the components of the drug.
• Dosage depends on the severity of the pathological condition and age of the patient. For children 3-5 years, appoint 2.5 ml of syrup 3 times a day, for children 6-14 years, 2.5-5 ml 3 times a day, for children over 14 years and adults 5-10 ml 3 times in a day. Duration of treatment is 2-3 weeks.
• Side effects are rare and manifest as allergic reactions that occur after the drug is discontinued. Overdose is manifested by painful symptoms in the epigastric region, attacks of nausea and vomiting. To resolve it, symptomatic treatment is indicated.

Agicold Tablets

For the prompt elimination of catarrhal diseases, correct and timely treatment is very important. Adjikold tablets are recommended for taking at the first sign of malaise. The drug is produced in blisters for 4 and 10 tablets. Each tablet contains 500 mg of paracetamol, 30 mg of caffeine, 10 mg of phenylephrine hydrochloride and 2 mg of chlorpheniramine maleate.

• Indications for use: elimination of flu and cold symptoms, relief of head, muscle and joint pain, nasal congestion and runny nose, lacrimation, chills. Dosage for adult patients - 2 tablets 2-4 times a day, for children from 6-12 years, 1 capsule up to 4 times a day, with an interval of 4-6 hours. The course of the drug should not exceed 5-7 days.
• Side effects occur in isolated cases. Patients encounter various allergic reactions, rashes on the skin, nausea and pain in the epigastric region. Sleep disturbance, dry mouth, headaches, and increased nervous excitement are also possible.
• The main contraindication to use is the intolerance of the components of the drug. Adjikold is contraindicated in cases of severe impairment of kidney and liver function, during pregnancy and lactation, in severe forms of diabetes mellitus, acute pancreatitis, hyperthyroidism and for children younger than 6 years.
• Overdose can occur due to the action of paracetamol. It manifests itself as pronounced pallor of the skin, nausea, vomiting, increased activity of hepatic transaminases. Symptomatic therapy, gastric lavage and activated charcoal are indicated for treatment.

Agicold Hotmix

Another popular form of production of medicines for the treatment of colds is powders for preparing solutions with different flavors. Adjikold hotmix has an orange flavor and is available in packs of 5, 10 and 50 sachets of 5 g. Granular powder contains the same active ingredients as other forms of the drug, ie: paracetamol, caffeine, phenylephrine hydrochloride, chlorpheniramine maleate.

• It is used for symptomatic treatment of colds and infectious and inflammatory diseases, which are accompanied by headaches and muscle pains, fever, nasal congestion and acute rhinitis. The medicine is taken 1 sachet 4 times a day. The contents of the sachet should be poured into a glass and pour 200-250 ml of hot water.
• Side effects: increased fatigue, decreased speed of psychomotor reactions, dry mouth, temporary increase in blood pressure and increased heart rate, epigastric pain, urinary retention.
• Contraindications: hypersensitivity to paracetamol or any other components of the drug, the age of patients under 15 years, hyperoxaluria. Do not use with tricyclic depressants or monoamine oxidase inhibitors.
• With special care, the drug is prescribed for such systemic manifestations: hypertension, bradycardia, pregnancy and lactation, hyperthyroidism, prostatic hypertrophy, recent myocardial infarction or unstable angina.
• Overdose: decreased appetite, pallor of the skin, liver necrosis, nausea and vomiting. A more pronounced toxic effect occurs with a single application of 10-15 g of the drug. In this case, emergency medical care with gastric lavage and monitoring of vital signs is shown.

Pharmacodynamics

Agicold is a combined preparation, as its composition includes several components. Pharmacodynamics is determined by such substances:

• Paracetamol is an antipyretic and analgesic. Reduces the excitability of the center of thermoregulation of the hypothalamus and is involved in inhibiting the synthesis of prostaglandins.
• Phenylephrine hydrochloride is a vasoconstrictor, whose action is aimed at eliminating nasal congestion and decreasing secretions from the sinuses.
• Caffeine - a stimulant that affects the central nervous system, reduces the feeling of drowsiness and fatigue. Increases mental and physical performance.
• Chlorpheniramine maleate is a decongestant and antiallergic agent. Its action is aimed at reducing vascular permeability. Removes swelling and redness of the nasal mucosa. Eliminates the symptoms of allergic rhinitis and facilitates nasal breathing.

Pharmacokinetics

The cold remedy begins to act 30 minutes after application, providing an antipyretic and analgesic effect. Pharmacokinetics is expressed by such components:

• Paracetamol - quickly absorbed from the digestive tract and binds to blood plasma proteins. The maximum concentration in plasma is observed after 1-4 hours. Metabolizes in the liver, forming glucuronide paracetamol sulfate. The metabolic process is associated with a general clearance and a microsomal enzyme system. Penetrates through the placental barrier. Glucuronidation products have nephrotoxic and hepatotoxic properties. The substance is excreted in the form of conjugation products, about 5% is excreted unchanged.
• Phenylephrine hydrochloride is poorly absorbed from the gastrointestinal tract, it is metabolized on first passage through the liver with monoamine oxidase in the walls of the intestine. Undergoing biotransformation, it forms sulfated derivatives - phenylephrine 3-O-sulfate. Bioavailability is low, subject to systemic absorption.
• Chlorpheniramine maleate - completely and quickly absorbed from the digestive tract and spreads through the tissues of the body. About 70% of the substance binds to plasma proteins. The half-life is 8 hours. Metabolizes in the liver. Gradually absorbed from the gastrointestinal tract, the maximum concentration in the blood plasma occurs in 3-6 hours. It is excreted in urine, part unchanged and part of the substance in the form of dimethylated metabolites. The rate of excretion is completely dependent on the pH of the urine.
• Caffeine - quickly absorbed, the maximum concentration in the blood plasma is reached after 5-90 minutes after oral administration. Rapidly destroyed in cells, penetrates through the placental and blood-brain barrier. About 35% is associated with blood plasma proteins. Rapidly metabolizes in the liver, forming metabolites: 1-methyluronic acid, 1-methylxanthine and 7-methylxanthine. All metabolites undergo intensive biotransformation, the elimination period takes about 5 hours. It is excreted by the kidneys.

Dosing and administration

The cold remedy has several forms of release, on which the method of application and dose depends. Adjikold is appointed according to the following schemes:

• Tablets - adults 2 pcs. 1-4 times a day, for children 1 pc. 1-4 times a day. The course of treatment is 5-7 days.
• Ointment - is intended for external use and inhalation in rhinitis. A small amount of the drug must be distributed around the neck, back, chest and grind well. After rubbing it is necessary to wrap up and stay warm.
• Syrup - for children 3-14 years for ½ - 1 teaspoon 3 times a day, for patients over 14 years and adults for 1-2 spoons 3 times a day. Duration of treatment is 14-21 days.
• Powder for the preparation of the solution - the contents of one sachet should be filled with hot water and mixed until completely dissolved. It is recommended to apply the medicine on one sachet up to 4 times a day. The course of treatment should not exceed 5 days.

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Use Ajikold during pregnancy

The possibility of using Adjikold during pregnancy should be determined by the attending physician. This is due to the fact that some of the substances that make up the drug can penetrate the placental barrier. The drug is prescribed in the event that the potential benefit to the mother is higher than the possible risks to the fetus. 

Contraindications

Effective elimination of colds completely depends on the selected drugs. Agicold is a combined remedy, but, despite its effectiveness, it has such contraindications for use:

• Intolerance of the components of the drug.
• Pregnancy and breastfeeding.
• The age of patients younger than 6 years.
• Simultaneous use with medicines, which include active ingredients Adjikold.
• Simultaneous use with tricyclic antidepressants, beta-blockers and monoamine oxidase inhibitors.

With special care the drug is prescribed for patients with blood diseases, hepatic or renal insufficiency, arterial hypertension, thyroid lesions. And also with diabetes mellitus, bronchial asthma, closed-angle glaucoma.

Side effects Ajikold

Incorrect use of the medicine for cold causes side effects. Agicold can provoke such symptoms:

• Allergic reactions (itching, rash, burning, urticaria, angioedema).
• Headaches and dizziness, increased excitability.
• Sleep disturbances.
• Attacks of nausea and vomiting, dry mouth.
• Pain in the epigastric region.
• Anemia and thrombocytopenia.
• Increased arterial and intraocular pressure.
• Retention of urine.

If the drug is used for a long period of time and at dosages exceeding the recommended levels, hepatotoxicity, nephrotoxicity, aplastic or hemolytic anemia can be observed.

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Overdose

The medicine should be used in the dosages prescribed by the doctor. Failure to follow the treatment recommendations can cause adverse symptoms. Overdose in most cases is associated with the action of paracetamol. There are bouts of nausea and vomiting, marked paleness of the skin, increased activity of liver transaminases and increased heart rate. To eliminate these reactions, it is necessary to rinse the stomach, take activated charcoal and, if necessary, conduct further symptomatic therapy.

Interactions with other drugs

For rapid and effective treatment of common cold, an integrated approach is recommended. Interactions Adjikold with other drugs should be monitored by the attending physician. This is associated with a high risk of adverse reactions from many organs and systems.

• The drug is not recommended for taking with other medicines that contain paracetamol.
• The drug enhances the action of MAO inhibitors, ethanol and sedatives.
• When used with antidepressants, antipsychopathic, antiparkinsonian and phenothiazine derivatives, the risk of constipation, dry mouth and fluid retention in the body increases.
• When interacting with glucocorticosteroids, the risk of developing glaucoma increases.
• Paracetamol slows down the action of diuretics.
• Chlorpheniramine in combination with MAO inhibitors can cause hypertensive crisis and hyperpyrexia.
• Tricyclic antidepressants increase their symptomatic effect.
• Halothane increases the risk of ventricular arrhythmia.

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Storage conditions

Regardless of the form of release, the preparation should be kept in a place protected from sunlight, moisture and inaccessible to children. The recommended storage temperature should not exceed 25 ° C.

Shelf life

Agicold must be used within 36 months from the date of its manufacture. Shelf life is indicated on the product package. Improper storage of the medicine shortens its useful life. Overdue product is contraindicated to use and must be disposed of.