Drugs for treatment and restoration of the liver

To eliminate liver diseases, special medicines are used. Consider the most popular and effective drugs, their types, indications for use and cost.

Medicines for the liver are called hepatoprotectors, they are appointed by the attending physician to eliminate violations of the functioning of the body. They are necessary to restore the cells of the body with prolonged antibacterial or anti-tuberculosis therapy, the use of painkillers, antitumor drugs and other medicines.

Faced with the problem of choosing a drug, patients are interested in the same questions. Which tool is better, more efficient, safer and cheaper? To date, the pharmaceutical market is represented by a variety of hepatoprotectors that are used for both treatment and organ rehabilitation:

• Phospholipids.
• Herbal remedies.
• Derivatives of amino acids.
• Bile acids.
• Homeopathic preparations.
• Biologically active additives.
• Medicaments of animal origin.

All drugs have different effects on the body and have different efficacy. Focusing on the results of diagnosis and analysis, the symptomatology and severity of the disease, the doctor selects the medicine.

The largest gland in the human body is the liver. The body performs many important functions: it participates in digestion, accumulates blood and glucose, neutralizes toxins and harmful substances, produces hormones and enzymes, cholesterol, bilirubin. The slightest disturbance in its functioning negatively affects the person's health.

Medicines for liver treatment are used to eliminate various diseases and restore damaged cells. Consider the most popular of them:

1. Plant hepatoprotectors

Issued in the form of capsules and tablets with an enteric coating. In this category, well-proven drugs that include silymarin, which has a pronounced health effect:

• Karsil - tablets with active substance - fruits of dry milk thistle spotted.
• Gepabene - capsules with an extract of a medicinal smoky and milk thistle.
• Silimar - tablets with an extract of dry milk thistle and other substances.

Have minimal toxic effect on the body.

2. Essential phospholipids

Medications are used in the treatment and prevention of cirrhosis, fatty degeneration, chronic, toxic and alcoholic hepatitis, radiation syndrome. The drugs are components of the cell wall of hepatocytes. They penetrate into the lipid layer of damaged cells and improve their functioning.

The drug intake minimizes energy costs, increases enzymatic activity and the physico-chemical properties of bile. To achieve a stable therapeutic effect, long-term use is necessary, preferably intravenous administration. The most popular medicine from this group is Essentiale and Essentiale Forte N.

3. Biologically active additives

Many patients are sure that food supplements and various dietary supplements are absolutely safe, and they can be taken without medical permission. But this is not so, some additives have hepatotoxic properties and, when interacting with other agents, cause many side-effects. BADs are not used as the main means, they are used in complex therapy or as an auxiliary medicine.

[1], [2], [3], [4]

Indications for the use of drugs for the liver

Use of any medication is possible only with the appropriate medical clearance. Indications for the use of drugs for the liver depend on the severity of the underlying disease and the presence of concomitant, the patient's age and other characteristics of the body. To date, there are many hepatoprotectors that are prescribed in such cases:

• Hepatitis - most often prescribed for the elimination of viral hepatitis, when antiviral drugs did not have the expected result or the conduct of such therapy is impossible. Hepatoprotectors are used both in complex treatment and for disease prevention.
• Fatty degeneration - occurs in patients with type 2 diabetes and obese patients. In such patients, fat cells form in the liver, which disrupt its normal functioning. For treatment, hepatoprotectors, cholesterol lowering drugs, antidiabetic drugs, diet and physical activity are prescribed.
• Alcoholic hepatitis with the risk of cirrhosis - before starting treatment it is necessary to completely abandon alcohol, since the pharmaceuticals will not have a therapeutic effect. If the intake of alcohol continues, then no drugs will help restore the diseased organ.
• Toxic, medicinal hepatitis - medicines not only eliminate the symptoms of the disease, but also help restore the organ. A prerequisite for recovery is the elimination of factors that provoked malaise.

It is necessary to understand that it is difficult to completely restore the health of the liver with medicines only, so the patient is prescribed a special diet, physiotherapy, mandatory treatment of the pancreas and gallbladder, that is, the organs that take part in digestion.

Medicines for the treatment of liver cirrhosis

One of the dangerous diseases that practically does not give in to treatment is cirrhosis. The choice of the method of therapy and drug depends on the stage and activity of the pathological process. To date, there is no such means that could completely eliminate the disease. Medications are aimed at correcting possible complications and protecting the body from further destruction.

Medicines for cirrhosis of the liver:

• Inactive form - with compensated cirrhosis, vitamin preparations are used for treatment. As a rule, patients are prescribed vitamin-mineral complexes: Alphabet, Vitrum, Duovit, Biomax.
• Cirrhosis of medium activity - patients are prescribed plant and vitamin remedies. This is a vitamin complex of group B, vitamin C, rutin, folic and lipoic acid. From medicines prefer drugs on the basis of milk thistle and artichoke.
• Decompensated cirrhosis - at this stage there are various complications. For therapy use lipoic acid, which is used orally / intravenously and various hepatoprotectors.
• Cirrhosis complicated by ascites - the patient is prescribed diuretic drugs: Spironolactone, Furosemide, Triampur.
• Cryptogenic cirrhosis is the most dangerous form of the disease. For the treatment of pathology with an unidentified cause, hepatoprotectors, herbal remedies, amino acid derivatives and other medications are used.
• Viral cirrhosis - treatment is based on the correction of the underlying disease. Most often, patients are prescribed prednisolone. Dosage and duration of therapy are selected individually.

In the treatment of cirrhosis, not only drug therapy is required, but also the diet, a complete refusal from smoking and alcohol. If the pathology is detected in the early stages, then the liver can be restored.

Form of issue

The effectiveness of the drug is determined not only by its composition, but also by the form of release. Liver remedies are available in this form:

• Pills.
• Capsules covered with enteric-dissolvable coating.
• Powders for the preparation of solutions for oral administration.
• Ampoules for injection (drip and intravenous).
• Drops (for small children).
• Teas, phytocomplexes.

The doctor appoints the most appropriate form of release, focusing on the course of the disease and the patient's age.

[5], [6], [7]

Pharmacodynamics

The effectiveness of the drug is determined by its biochemical properties. Pharmacodynamics provides information about the pharmacological group of the drug, its composition and indications for use. Consider these characteristics on the example of different groups of drugs prescribed for the treatment of liver diseases.

• Plant hepatoprotectors

Active substances Gepabene - extracts of medicinal plants. The active ingredient of silymarin is produced from the fruits of milk thistle. Has a choleretic effect, normalizes the tone of the bile ducts and the amount of bile, improving its outflow into the intestine. It improves the function of protein formation, stabilizes the membranes of hepatocytes.

• Essential phospholipids

Essentiale is a highly purified fraction of phosphatidylcholine. The active substances are soybean phospholipids, which in their structure are similar to elements of hepatocytes. The lack of these substances leads to a violation of fat metabolism and the development of fatty degeneration. The medicine restores cellular structures, accelerates the regeneration process and slows the formation of connective tissue.

• Preparations of animal origin

Hepatosan is a drug with freeze-dried cells of the pig liver. Strengthens the detoxification function, sorbs and removes toxins, accelerates the regeneration of hepatocytes. It has two phases of action: intestinal and metabolic. The first one detoxifies toxic substances in the intestine, while the second biological components restore the functional activity of the damaged organ. The composition of the remedy includes vitamins, essential phospholipids, enzymes, amino acids.

• Amino acids

Ursosan is a hepatoprotector with choleretic action. It is available in the form of capsules for oral use with the active substance ursodeoxycholic acid. Forms non-toxic mixed micelles with toxic bile acids, preventing damage to cell membranes of hepatocytes. Reduces the amount of cholesterol in the bile, promotes its absorption and excretion. Dissolves cholesterol gallstones and prevents the formation of new ones. The active component slows the aging and death of hepatocytes.

• Biologically active additives

Liv 52 is a combined drug with hepatoprotective, anti-inflammatory, choleretic and antitoxic action. Improves the process of digestion and assimilation of food. It restores liver cells, minimizes any degenerative changes and enhances intracellular metabolism. Normalizes the level of bilirubin and other hepatic enzymes, improves the colloidal properties of bile and prevents stone formation.

Pharmacokinetics

To treat diseases of the gastrointestinal tract apply different medications, which differ not only in their composition, but also in the forms of release. Pharmacokinetics allows to learn about the processes of absorption and metabolism of the drugs used.

• Plant hepatoprotectors

The active ingredient Hepabene practically does not dissolve in water, forms salts with alkalis. If the medicine enters the intestine, it is absorbed into the blood with digested intestinal bacteria. Maximum plasma concentration for oral administration is achieved in 2 hours. Metabolites are excreted with bile. The half-life is 5-6 hours.

• Essential phospholipids

About 90% of the dose of Essentiale is absorbed in the small intestine. The active components are cleaved by phospholipase A to 1-acyl-lysophosphatidylcholine. Half of the obtained substance undergoes reverse acetalization when absorbed in the intestinal mucosa. The maximum concentration in blood plasma is reached in 6-24 hours after application. It is excreted in the form of metabolites with feces and urine.

• Preparations of animal origin

Hepatosan is released in the form of capsules with enteric-coated capsules for oral administration. After entering the body, the active substances quickly spread through the body, providing a therapeutic effect. It is excreted in the form of metabolites with urine.

• Amino acids

Ursosan is absorbed from the small intestine and ileum. The concentration of the active substance in the blood plasma depends on the dose taken. Binding to plasma proteins is high, ursodeoxycholic acid penetrates the placental barrier. Metabolized in the liver, excreted with bile, feces and urine.

• Biologically active additives

The pharmacokinetic properties of Liv 52 are due to the cumulative effect of its active components.

Drugs for the liver after alcohol

Alcohol destroys liver cells not only in chronic alcoholics, but also those who like to drink alcohol from time to time. But the situation is reparable, since the body has the ability to recover. There are many medications that will help to normalize the functioning of the liver and accelerate the regeneration of damaged cells.

The best medicine for the liver after alcohol:

• Restorative - this category includes hepatoprotectors, agents with essential phospholipids. Most often used: Essentiale, Phosphogliv, Essliver.
• Preparations (catalysts) for activation of regeneration are vitamin complexes with amino acids, creating an environment for the formation of new hepatites. This category includes: D i Guard, Dipan.
• Cleansers - facilitate the work of the body, remove toxins and eliminate signs of intoxication. Patients are appointed: Karsil, Hepabene, Heptral, Silimar.

All of the above medicines can only be used for medical purposes. After diagnosing the patient's condition, the doctor selects the optimal medicine, determines the necessary dosage and duration of therapy. But the main rule of treatment after alcohol abuse is a total refusal of alcohol.

[13], [14]

Drugs for liver restoration

A lot of drugs are used to restore the liver. They can have a plant base, enzymes from animal liver or amino acids and essential phospholipids. There are also combined means of complex action. To name the best means is impossible, that as for each case there is an optimum preparation.

Drugs for liver restoration:

• Biologically active additives - Artichoke extract, Heptralite, Liposil, Gepatrin.
• Tablets and capsules - Energil, Essler forte, Karsil, Liv 52.
• Homeopathic remedies - drops of Galsten, Hepel tablets.

For recovery, you can use not only pharmacological agents, but also methods of alternative medicine. For example, aromatherapy with anise, rosemary, juniper and other essential oils. The recipe of pumpkin with honey has a special popularity and therapeutic effect. A ripe vegetable should be washed, cut off the top and cleanse the seeds. Inside, pour honey and close with a cut top. Leave the vegetable to be infused at room temperature or in a cool place for 10 days. At the end of this period, drain the honey and take 1 spoon 2-3 times a day. The course of such therapy is 1-2 months.

[15], [16], [17]

Medicines for cleansing the liver

Many people face such a problem as liver disease. The main filter of the body ceases to fully cope with its functions, causing violations by other organs and systems. To eliminate the pathological condition, as a rule, drugs are used on a plant basis. Such agents allow to regulate enzymatic activity, minimize the effect of toxins and increase resistance to negative effects of harmful substances.

The main list of medicines for liver cleansing:

• HeptraLight - contains a metabolically active substance, effectively removes toxins. For treatment, take 200 mg once a day.

• Liposil - a drug based on the extract of milk thistle and soybean phospholipids. To cleanse the liver take 1-2 capsules per day.

• Bondjigar - active ingredients: chicory, nightshade, barberry, ecliptic white. The preparation is produced in the form of gelatin capsules and syrup. For cleansing, take 1-2 capsules or 15 ml of syrup 3 times a day after meals.

• Allochol - contains condensed bile, activated charcoal, nettle extract and garlic. Strengthens the synthesis of bile acids and bile. In a day you can take 1-2 tablets 3-4 times.

• Silymarin - this substance is a part of many drugs. Favorably affects the hepatocytes, speeds up the excretion of bile. For treatment, take 200-300 mg per day.

Magnesium is used to purify the liver and gallbladder. This substance increases the acidity of the stomach and has a powerful choleretic effect, so it can be used only by permission of the doctor. To prepare the medicine in a glass of boiled water, dissolve 2 tablespoons of magnesium and drink the solution 30-40 minutes before eating. Before and after taking the remedy it is recommended to lie for 1-2 hours on the right side.

A complete list of medicines for cleansing the liver can be found here.

Liver remedies for antibiotics

To eliminate many diseases, antibiotic agents are used. Their long use negatively affects the health of all organs and systems. Drugs for the liver after antibiotics restores the filter, since it is he who removes the products of the breakdown of medicinal products, toxins and other harmful substances from the body.

To restore the body used special means - phytopreparations, that is hepatoprotectors. The most popular medicines:

• Medicines with vegetable components and milk thistle - Karsil, Liv 52, Galstena, Gepabene, Ovesol. Stabilize the cell membranes and have an antioxidant effect.
• Essential phospholipids - Essentiale forte, Essley, Phosphogliv. Accelerate the processes of regeneration, have antifibrotic action.
• Means with ursodeoxycholic acid - Ursolfak, Ursosan. Protect cell membranes, eliminate the inflammatory process and accelerate the excretion of bile.

For treatment after antibiotic agents, alternative agents are excellent. But do not forget that such methods are ancillary therapy, that is, an addition to the basic treatment.

• Take in equal proportions milk thistle, corn stigmas and chicory, pour them 200 ml of boiling water. The broth should be infused for 10-12 hours, after which it must be filtered and taken before meals.
• Chicory flowers pour 2 cups of boiling water and cook over low heat for 20-30 minutes. Medication strain, add a couple of lemon slices and a spoonful of honey, eat like tea.
• Finely chop 1 kg of cabbage, add berries of currant or cowberry, kiwi and orange to it. Salad well mix and prepare a dressing from lemon juice, olive oil, spices and apple cider vinegar. Salad to eat for a week with a slice of black bread.

Medications for the liver in ampoules

To eliminate diseases of the liver and the digestive tract, many drugs are used, different forms of release. Focusing on the results of tests and diagnosis, the course of the disease and the characteristics of the patient's body, the doctor selects the optimal treatment option.

Medicines for the liver in ampoules:

1. Heptral

Hepatoprotector with antidepressant activity. Has choleretic, cholekinetic, antioxidant, regenerating, neuroprotective action. The active substance - ademetionine, replenishes its deficiency in the body and takes part in the biological reactions of transmethylation. Increases the glutamine content in the liver, normalizes metabolic reactions and has a choleretic effect.

• Heptral is prescribed for the treatment of hepatitis of different etiology, cholecystitis, cholangitis, cholestasis, toxic lesions. Intravenous administration is indicated for fatty degeneration, cirrhosis, encephalopathy, withdrawal syndrome. Ampoules are used intramuscularly or intravenously. The daily dosage should not exceed 800 mg.
• It is contraindicated to use in the І-ІІ trimester of pregnancy and lactation. Do not prescribe for patients under 18 years of age and with individual non-transference components. Side effects occur when the recommended dosage is exceeded. Most often these are allergic reactions and dyspeptic disorders, gastralia.

2. Essentiale H

Solution for intravenous administration from the pharmacological group of hepatoprotectors. Active substance - essential phospholipids 250 mg. The active component regulates the metabolism of lipoproteins and increases their binding to cholesterol. Has a detoxifying, restoring effect, prevents the formation of connective tissue in the liver.

• Used only for intravenous administration, intramuscular injections can cause local allergic reactions. To dilute, use a 5-10% solution of dextrose. The resulting solution should be transparent during the period of administration. The use of electrolyte solutions (Ringer's solution, isotonic) for breeding is contraindicated.
• Indications for use: hepatitis, fatty degeneration, cirrhosis, toxic damage and necrosis of liver cells. Helps with toxicosis during pregnancy, hepatic coma and precoma, with radiation syndrome and psoriasis, during the pre and postoperative period.
• The use of this drug during pregnancy is possible only for medical purposes, since gasoline penetrates the placental barrier and adversely affects the development of the fetus. It is not used to treat patients younger than 3 years of age and hypersensitivity to components. Side effects are manifested by the immune system, causing allergic reactions and itching.

3. Remaxol

Balanced infusion solution with hepatoprotective properties. Produced in glass bottles of 400 ml. Active ingredients: succinic acid 5.28 g, meglumine 8 g, riboxin 2 g and other components. The drug reduces the content of bilirubin and its fractions, minimizes the activity of excretory enzymes of hepatites and oxidizes cholesterol, converting it to bile acids.

• The main indications for use: violations of the liver in toxic, medicinal and alcoholic hepatitis. Complex treatment of viral hepatitis. With the drip introduction, the active components quickly spread to the tissues of the body. The daily dosage is 400-800 ml, the rate of administration is 2-3 ml / min.
• Contraindicated in pregnancy and lactation. Do not prescribe to children of childhood and with individual intolerance of components. Under medical supervision apply for gout, nephrolithiasis and hyperuricemia. It is not recommended to mix in one vial with other means for intravenous administration.
• In case of an overdose, side effects are possible. With the rapid administration of the solution, a feeling of heat, dryness and perspiration in the throat, hyperemia of the skin. Possible allergic reactions, nausea, headaches, vomiting, dizziness. When these symptoms appear, you need to seek medical help to adjust the dose.

4. Laennec

Immunomodulator, available in ampoules for injection. Stimulates humoral immunity, increases the activity of phagocytes, increases bactericidal activity of leukocytes. Active components stimulate the regeneration of damaged cells, prevent deposition of cholesterol and lipids.

• Injections are prescribed to eliminate chronic liver diseases of different etiologies. The medication helps with atopic dermatitis and chronic recurrent herpes. When liver pathologies are prescribed intravenously, 2 ml per day. The maximum dosage should not exceed 10 ml per day. The course of treatment takes 2-3 weeks.
• Contraindicated for use in children, during pregnancy and lactation. If these recommendations are not followed and the prescribed dosage is exceeded, side effects are possible. Most often, it is pain and numbness at the injection site, allergic reactions.

5. Cryomelt MN

Solution for injection, hepatoprotector. The active ingredient is honey, produced in 1 ml ampoules. The drug is a sterile native solution of honey in water, prepared by special technology. It has an antioxidant effect and stabilizes the membranes of damaged cells. Hepatoprotective activity provides protection from the negative effects of toxins and harmful substances.

• Cryomelt is prescribed for the treatment of chronic hepatitis and toxic lesions, as well as for fatty degeneration of different etiologies. Patients are given 1 ampoule per day, the course of treatment is 10-20 days.
• Contraindicated with hypersensitivity to bee products and for patients of childhood. With special care is used by patients with diabetes mellitus. Side effects are manifested as allergic reactions of varying severity.

Liver remedies for children

Treatment of any diseases in patients of childhood requires a professional medical approach. Children are prescribed safe drugs with minimal side effects and contraindications.

Consider effective medicines for the liver for children:

• Galstena - a homeopathic remedy on a plant basis. Has hepatoprotective, anti-inflammatory, choleretic and antispasmodic properties. It is used for complex therapy of pancreatitis, liver restoration, after prolonged use of antibiotics, for hepatitis and other pathologies. It is released in drops, which allows it to be used for the youngest patients.

• Essential - the active substances of this medication are essential phospholipids. In their structure they are similar to endogenous membranes of liver phospholipids. Assign with fatty degeneration, acute and chronic hepatitis, necrosis of the body cells and toxic lesions. Available in the form of capsules and injections for intravenous administration.

• Allochol - a drug that enhances the formation of bile. It improves the secretory function of the digestive tract, reduces the processes of fermentation in the intestine, accelerates the regeneration of damaged cells of the liver and gallbladder. It is prescribed for the treatment of chronic hepatitis, with cholecystitis, cholangitis, prolonged constipation associated with intestinal atony. It is available in the form of capsules with an enteric coating.
• Antral - hepatoprotector, is used to treat hepatitis of various etiologies and minimizes the signs of dyspeptic and asthenovegetative syndrome. Assign for the treatment of cirrhosis and fatty degeneration, various inflammatory and infectious diseases of the digestive tract. Antral is available in capsules for oral administration.

• Betargin - contains amino acids (betaine, arginine), necessary for the normalization of the functions of the hepatobiliary system. It is available in the form of a solution for oral administration. It is used to treat functional disorders of the liver, with hepatosis, viral hepatitis, steatosis, medicamentous and toxic organ damage.

Method of administration and dose of drugs for the liver

In order for the treatment to be quick and effective, the doctor prescribes to the patient the way of application and the dose of the medication. For the liver, different formulations are used, so the therapeutic effect depends on the method of their use.

• Plant hepatoprotectors

Gepabene appoint 1 tablet 2-3 times a day. If the pain in the right upper quadrant occurs at night, then an additional capsule is allowed before bed. The maximum daily dose of 6 tablets in 3 divided doses, duration of therapy from 3 months.

• Essential phospholipids

The daily dose of Essentiale is 4-6 tablets in 3-4 divided doses, the duration of treatment is individual for each patient. Tablets are not chewed, washed down with water. Dosing solution for intravenous injection - up to two ampoules a day.

• Preparations of animal origin

Hepatosan take 200-400 mg, depending on the indications. The course of treatment is 10-20 days.

• Amino acids

Ursosan is taken in the calculation of 10 mg / kg body weight. The daily dosage is divided into 2-3 doses. For patients younger than 2 years, the dosage is selected individually.

• Biologically active additives

Liv 52 is taken for both curative and preventive purposes. For children over 6 years and adults 1-3 tablets 2-3 times a day. Drops are used to prevent liver diseases, 10-20 drops 2 times a day for children over 2 years and for 80-160 drops for adults.

Use of medicines for the liver during pregnancy

Pregnancy is not only a long-awaited period for every woman, but also quite responsible. During pregnancy, the work of some organs and systems is disrupted, but the liver most often suffers. Violated the process of blood supply, which affects negatively on hepatic functionality. This process is considered natural, because after the birth the body's work is restored. But future mothers may exacerbate chronic diseases that require treatment.

Consider drugs for the liver during pregnancy, which are used to prevent and eliminate pathological conditions:

• Essentiale Forte is a complex agent with phospholipids, improves the cell membranes of the damaged organ. It consists of natural components that do not penetrate the placental barrier. Can be used in any trimester.

• Legalon is a herbal remedy with the active substance of milk thistle. Has a strong hepatoprotective effect, improves intracellular metabolism, stabilizes membranes of hepatocytes. It is used to treat many diseases, regardless of etiology and severity.

• Karsil is one of the most popular drugs for restoring a weakened or damaged liver. The active ingredient is the thistle extract. It is used during pregnancy and for patients of child age. Well tolerated, not addictive.

• Heptral - hepatoprotective agent with active substance ademetioninom. It regenerates, detoxifies, antioxidant and neuroprotective. Effective in the treatment of toxic, viral and inflammatory liver damage.
• Hofitol - a combined remedy with choleretic, diuretic and hepatoprotective properties. The active ingredient is artichoke extract. It is used for chronic and acute diseases of the liver and organs.

Treatment of any diseases in expectant mothers has certain difficulties, since many drugs are contraindicated to use. Use of medicines for the liver during pregnancy is possible only for medical purposes. This is due to the fact that the active substances can penetrate the placental barrier, adversely affecting the development of the fetus.

A woman is selected safe preparations, usually on a plant basis. Many hepatoprotectors not only restore the work of the liver and organs of the digestive tract, but also alleviate the state of pregnancy in toxicosis.

Contraindications for use

Medications have not only indications, but also contraindications to the use. Consider the prohibitions on the use of medications to restore hepatocytes.

• Plant hepatoprotectors

Gepabene is not allowed to be used in cases of liver and bile duct disease in acute form, with intolerance to the components of the drug and for the treatment of patients younger than six years old.

• Essential phospholipids

Essentiale is prohibited with increased sensitivity to its active ingredients. Solution for injection is not prescribed for newborns and premature babies, since the composition of the product includes benzyl alcohol.

• Preparations of animal origin

Hepatosan has a unique contraindication - intolerance of active components.

• Amino acids

Ursosan is not prescribed for patients with acute inflammatory lesions of the bile duct and gall bladder, as well as in violation of the contractile function. Tablets are not prescribed for calcified stones and biliary colic, impaired renal and hepatic function. The use of medication in pediatric practice is possible for patients older than 5 years.

• Biologically active additives

Liv 52 is not used for intolerance of its components, during pregnancy and lactation. With special care is used in diseases of the gastrointestinal tract and for the treatment of children with pathologies of the biliary tract.

[8], [9], [10], [11], [12]

Side effects

Non-compliance with medical recommendations for the use of tablets, leads to undesirable effects. Side effects of drugs for the liver are manifested by many organs and systems. Most often, allergic reactions: skin itching, rash, redness.

Possible disorders of the gastrointestinal tract and cardiovascular system. Patients complain of headaches, dizziness. Most hepatoprotectors and essential phospholipids are well tolerated, but only if the prescribed dosage and duration of therapy are observed.

Overdose

Elevated doses of the drug may cause adverse symptoms. Overdosing manifests itself as an increase in side effects. Most of the medicines for the liver are well tolerated. In rare cases, there are signs of a disorder of the gastrointestinal tract, headaches.

To eliminate the symptoms of an overdose, it is recommended that you stop taking the medicine and seek medical help to adjust the dose and duration of therapy.

Interactions with other drugs

The use of several drugs in the elimination of one disease is possible only with the appropriate medical purpose. Interaction with other drugs depends on the form of release of the main medication.

Injections for intravenous and intramuscular administration should not be confused with other drugs. Since local allergic reactions are possible, redness at the injection site and other symptoms. Particular attention should be paid to solutions for ampoule dilution. In any case, when several drugs are used simultaneously, it is necessary to observe a time interval of 1-2 hours to prevent side effects.

Storage conditions

The therapeutic properties of drugs largely depend on the storage conditions. Tablets should be kept in their original packaging protected from sunlight and out of the reach of children. These recommendations apply to injections for intravenous / intramuscular administration.

Particular attention should be paid to the temperature regime, the temperature should not exceed 25 ° C. Open ampoules for injection should be used on the same day. If the drug is cloudy or flakes appear in it, then this medicine is contraindicated to use. This applies to tablets, if the capsules have changed their physico-chemical properties, their application can lead to a number of unfavorable symptoms.

Shelf life

Liver remedies help restore the cells of a damaged organ and make it function. Such medications are used in therapy of patients of all ages. In order for the treatment to be safe and effective, before using the drug it is necessary to study its instructions and pay attention to the expiration date. The use of overdue tablets or injections threatens with side effects, disrupts the work of all organs and systems.