The active component of udenafil is a selective inhibitor of a specific element of PDE-5 (reversible action), which helps the cGMP exchange process.
Udenafil does not have a direct relaxing effect on the isolated cavernous body, although under the influence of sexual stimulation it increases the relaxing effect of nitric oxide (by slowing down PDE-5 responsible for the destruction of cGMP inside the cavernous body).
As a result, the smooth muscles of the arteries relax, and the blood flows to the tissues inside the penis, stimulating the erection. If sexual stimulation is not available, the medicine will not have the desired effect.
In vitro tests demonstrated that udenafil acts as a selective inhibitor of the enzyme PDE-5. This element is located inside the smooth muscles of the cavernous body, and with it the vessels of the organs, and in addition to the musculature of the skeleton, the kidneys with platelets, as well as the cerebellum with the lungs. Udenafil inhibits the element of PDE-5 more than 10,000 times faster than enzymes PDE-1 and PDE-2, as well as FDE-3 with PDE-4, located inside the brain with the heart and liver, and in addition blood vessels and other organs.
Along with this, the acting component is 700 times more potent on PDE-5 than on the element of PDE-6 (it is in the retina, responsible for the perception of colors). Udenafil does not slow down the activity of PDE-11, as a result of which it does not cause muscle and lumbar pains, as well as signs of testicular toxicity.
Thanks to the active substance improves the erection, which contributes to the successful implementation of sexual intercourse.
The drug lasts up to 24 hours. It begins to manifest itself after half an hour after admission (under the condition of sexual arousal in a man).
In healthy men, the active component does not provoke a significant change in the values of the SAD, as well as the DAD with respect to the placebo in the recumbent and standing positions (the maximum lowered level averages 1.6 / 0.8, and 0.2 / 4.6 mm Hg, respectively. St.).
Together with this, udenafil does not change the color perception (green / blue), since it has a weak affinity for the element of PDE-6. The substance does not affect the indices of pressure inside the eyes, visual acuity, and at the same time the size of the pupils and ERG.
During the testing of udenafil, there was no clinically significant effect on the concentration index, and at the same time the amount of sperm released, and in addition morphology along with the motility of the spermatozoa.