Vestinorm

Westinorm has a histamine-like effect that helps improve microcirculation. The principle of therapeutic effect is studied only partially; There are several theories regarding the effect of the drug.

Betahistine is an artificial histamine analogue, has an effect on H1-terminations, acts as an antagonist of H3-terminations, and also shows weak activity relative to histamine H2-terminations. The active element helps to improve the blood flow processes inside the vessels of the inner ear, relaxing sphincters located in the microcirculation system of the inner ear. At the same time, the drug enhances blood circulation inside the basilar arteries.

Indications Vestinorm

It is used in case of Meniere's syndrome or disease, in which nausea, severe dizziness, ear noise, hearing loss and vomiting is observed.

Together with this medicament administered to eliminate symptoms vertigo (vestibular having character), developing at different pathologies (postoperative dizziness during neurosurgical procedures or ophthalmic, traumatic encephalopathy character maze failure Verteba basilar-type, atherosclerosis and vascular golovnomozgovyh neuritis vestibular character).

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Release form

The release of the drug substance is made in tablets (volume 8 or 16 mg) - 10 pieces inside the cellular packaging. In the box - 3 or 6 packs.

Pharmacodynamics

The drug helps to create vestibular compensation, and also increases the speed of the processes of recovery of vestibular activity, regulating the metabolism aimed at histamine release.

Drug efficacy confirmed by tests conducted with the participation of persons suffering from Meniere's disease and vestibular disorders. This subgroup of people showed a decrease in the intensity of attacks and a decrease in their frequency.

Pharmacokinetics

After consuming the tablets, the active element is absorbed at high speed inside the gastrointestinal tract. After that, betahistine undergoes metabolic processes with the formation of the metabolic component - 2-pyridyl acetone acid. In the case of the use of drugs when eating food plasma indicators of the metabolic element is slightly lower than in the case of eating on an empty stomach; the process of absorption from the gastrointestinal tract also slows down. Values Cmax metabolic component reaches after the 1st hour after drinking drugs.

The term half-life is 3.5 hours. Excretion of 2-pyridyl acetic acid occurs mainly along with urine; a small part of the substance is excreted by the kidneys and with feces.

Indicators of protein synthesis are extremely low - about 5%.

Dosing and administration

Use the medication orally. It is recommended to do this after a meal, swallowing the pill whole, without chewing.

The duration of the treatment and the size of the portion are selected by the attending doctor, taking into account the patient’s personal characteristics and the effectiveness of the therapy.

It is recommended to apply Westinorm at the initial stages of the pathology in order to prevent its progression or hearing loss in the patient.

The size of the daily portion is in the range of 24-48 mg.

Taking into account the size of the dosage, the frequency of drug use varies. At a dosage of 24 mg, 1 pill should be applied 2 times a day. Tablets with a volume of 16 mg are consumed 3 times a day for 0.5-1th unit. The 8 mg drug is used in the amount of 1-2 tablets 3 times a day.

The average duration of therapy is several months. Improvement of the patient’s condition sometimes occurs only after 2-3 weeks of daily use of the medicine.

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Use Vestinorm during pregnancy

Information regarding the use of Westinorm during pregnancy is not available. Apply the drug is allowed only after discussion with the doctor.

There is no information as to whether betahistine is excreted in breast milk. Whether to stop breastfeeding during treatment is determined by the doctor.

Contraindications

Among the contraindications:

• pheochromocytoma;
• active phase BA;
• peptic ulcer;
• the presence of allergies to the elements of the drug.

Side effects Vestinorm

Usually the use of the drug is tolerated without complications. Most often, patients have nausea, gastric discomfort and headaches.

In addition, there are reports of bloating, itching, signs of allergies, rashes, angioedema, urticaria, and anaphylaxis.

Reducing the daily ration and use of the drug along with food allows you to eliminate some of the above negative manifestations.

Overdose

In case of intoxication, nausea, drowsiness and stomach pain develop. The introduction of too large portions, especially when combined with other drugs, can provoke complications in the work of the cardiovascular system and seizures.

Symptomatic treatment procedures are carried out. If less than 60 minutes have passed since the drug was consumed, gastric lavage should be performed and enterosorbents should be taken.

Interactions with other drugs

Drug efficacy is impaired by selegine, MAOI, and antihistamine substances (fencarol, zyrtec, tavegil with suprastin, xyzal, and kestin).

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Storage conditions

Westinorm is required to be kept in a closed area from children and sunlight at standard temperature values.

Shelf life

Westinorm can be used for a period of 36 months from the date of sale of the therapeutic agent.

Analogs

Analogues of the drug are substances Aviomarin, Stugeron, Avetid with Tsinarizin, Akuver and Vestikap with Betaserk, Cinnaridone and Tablets for motion sickness and nausea.

Reviews

Westinorm receives good reviews from patients on the forums. It is often prescribed to persons with IRR - to eliminate unpleasant manifestations. It is also often used for dizziness and speech disorders associated with received CCT.