Ursonost

Capsules based on ursodeoxycholic acid Urson are used for the therapy of hepatobiliary pathologies.

Indications of the ursonosta

Lipotropic medicine Urson can be prescribed:

• for softening the concrements of bile cholesterol etiology, not determined by the X-ray method (provided the biliary function is preserved);
• for the treatment of reflux gastritis with a reverse reflux of bile;
• to eliminate clinical signs in primary biliary cirrhosis in the compensation stage;
• for the treatment of hepatobiliary disorders in cystic fibrosis in childhood.

Release form

Ursonost is produced in encapsulated form, at 150 and 300 mg. The capsule is dense, white, with a fine-grained powder inside.

The blister contains 10 capsules. A cardboard box can include two or five blisters.

The active ingredient is Ursonost - ursodeoxycholic acid.

Pharmacodynamics

The active ingredient Ursonost is an epimer of chenodeoxycholic and bile acids, found in small amounts in human bile.

Ursodeoxycholic acid is able to dissolve cholesterol deposits, "neutralizing" the concrement-forming bile.

A number of mechanisms of Ursonost's action are known:

• depression of cholesterol in bile;
• an increase in the total amount of bile acids;
• the formation of a liquid-crystalline phase with a higher level of cholesterol dissolution.

Receiving Ursonet helps to reduce the level of cholesterol and salts in bile, speeds up the dissolution of cholesterol, which leads to relief of outflow of bile.

One of the priority properties of Urson is the decrease in bile lithogenicity. The drug is practically non-toxic, does not lead to significant disorders on the part of the liver, does not damage the mucous tissues of the digestive tract.

Pharmacokinetics

When administered orally, the active ingredient Ursonost is briefly absorbed in the small intestine, in the upper ileal gut by passive transition, and in the terminal region of the ileum through active transitions.

The suction speed is usually from 60 to 80%.

At the end of the assimilation reactions, bile acid is susceptible to almost complete hepatic conjugation, in the presence of amino acids of taurine and glycine. Further, the acid is excreted with bile.

The indicative values of clearance during primary passage in the liver can be about 60%.

Dosing and administration

Ursonost should appoint a doctor. Dosage and duration of therapy depend primarily on the weight of the patient and on the characteristics of the disease.

• To eliminate the bile-cholesterol stones, the dosage is determined from the calculation of 10 mg of Ursonost per kg of weight of the patient. The required number of capsules is swallowed whole, daily, at bedtime, regularly. Duration of admission can be from six months to a year. If, after 12 months of therapy, no positive dynamics are detected, Ursonost's treatment is discontinued. The dynamics of treatment is important to monitor once every six months, using the technique of ultrasound and radiography. At the same time, the danger of calcification of the concremental formations should be assessed. If signs of calcification are found, the therapy is completed.
• When inflammation of mucous gastric tissues with reflux of bile is enough to drink 1 capsule of Urson at night, for 10-14 days. The therapy regimen can be adjusted at the discretion of the treating doctor.
• In primary biliary cirrhosis, the daily volume of Ursonost should be 12-16 mg per kg of weight of the patient. During the initial 3 months of therapy, Urson is drunk three times a day. After improving the liver function indicators, the patient goes to the standard reception - once a day, at night.

Capsules are swallowed whole, with liquid. Reception is conducted daily at the same time.

With the primary form of biliary cirrhosis, at first, there may be a worsening of clinical symptoms - for example, itching. With such signs, therapy is continued, limiting Ursonot's intake once a day. After normalization of the patient's condition, the number of capsules gradually increases (weekly one capsule is added until the amount necessary for the treatment scheme is reached).

Use of the ursonosta during pregnancy

To date, not enough information has been collected regarding the possibility of treating pregnant women with the drug Ursonost. Studies that were conducted earlier on animals indicated the presence of teratogenic effects in the first half of pregnancy.

It is undesirable to apply Urson in the period of gestation without any particular indication. The doctor must in each case decide on the possibility of using Urson. However, given the lack of information about the drug, taking it during pregnancy and breastfeeding is still not recommended.

Contraindications

Medical specialists do not prescribe Ursonot for such diseases and conditions:

• when hypersensitivity to any substance from the composition of Urson;
• in the acute period of inflammatory diseases affecting the biliary system;
• with violation of patency of the bile ducts;
• with often diagnosed hepatic colic;
• in the presence of radiologically contrasting gallstones;
• with disturbed contractile work of the gallbladder;
• with unfavorable completion of portoenterostomy, or in the disturbance of bile flow in patients of pediatric age with biliary atresia.

Side effects of the ursonosta

Adverse symptoms during the Ursonost course of treatment do not happen often, but they need to be known to both patients and medical specialists. Among such symptoms are most common:

• diarrhea, liquid and semi-liquid feces;
• tenderness (sometimes pronounced) in the projection of the liver;
• processes of calcification of bile concrements;
• the transition of the primary biliary cirrhosis to a temporary stage of decompensation, which regresses relatively after the termination of the administration of Ursonost;
• allergic manifestations in the form of dermatitis and rashes.

Overdose

The main sign of an overdose Urson is the appearance of diarrhea. Other symptoms are almost impossible, since with the development of diarrhea, the absorption of the drug is stopped, and the remnants of Urson are excreted from the body with calves.

If the patient complains of the appearance of diarrhea, the amount of Ursoston used decreases. If after a decrease in dosage diarrhea does not stop, then the drug is canceled altogether.

Special antidote therapy is not applied. Symptoms of overdose are eliminated by correction of the water-electrolyte level.

It was established that the long-term administration of high doses of Urson (more than 28-30 mg per kg per day) in patients with primary sclerosing cholangitis was accompanied by more pronounced signs of overdose.

Interactions with other drugs

You can not use Urson in combination with such medications as Cholestyramine, Cholestipol, anti-acid drugs, which contain oxy- and hydroxy-aluminum. The above mentioned agents envelop the ingredients of Urson in the intestinal cavity, which makes it difficult to assimilate and reduce the effect. If you can not avoid this combination, then you need to withstand at least 180 minutes between using these medications.

Ursonost is able to increase the degree of absorption of Cyclosporine. Therefore, in patients who are treated with Cyclosporine, it is important to check the level of this medication in the blood, and, if necessary, to correct it.

In some patients, Ursonost may interfere with the absorption of ciprofloxacin.

The combined administration of Ursony and medications, the metabolic processes in which are carried out with cytochrome P450 3A4, should be observed and evaluated (dosage adjustment may sometimes be necessary).

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Storage conditions

It is possible to store Urson at room temperature, away from sunlight and dampness. It is important to limit the access of children to the storage of medicines.

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Shelf life

Ursoon storage up to 5 years is allowed.