Treatment of cystitis with Palin

Cystitis is an inflammation of the lining of the bladder. Its symptoms are manifested by pain in the lower abdomen, pain and difficulty urinating, fever, general malaise, cloudy urine, the presence of "flakes" in it, sometimes blood fragments, and frequent urge to go to the toilet. It will not be possible to ignore its manifestations, and it is impossible to delay treatment, otherwise the infection may cover the kidneys. The urologist will prescribe the necessary antibacterial drugs according to the identified pathogens, diet, heavy drinking, diuretic herbal decoctions, and other therapeutic measures. Palin has a good reputation in the treatment of cystitis .

Indications Palina with cystitis

The drug is based on the active ingredient pipemidic acid, so it will help with cystitis for those whose disease is caused by bacteria that are sensitive to it. Palin is prescribed both for acute conditions, accompanied by interspersed blood in the urine, and chronic cystitis. These may be other diagnoses associated with inflammation of the urinary system: pyelonephritis, pyelitis, prostatitis, urethritis.

Due to their anatomical structure (short and wide urinary canal), women are most susceptible to the disease, this happens less often with men. Menstruation also contributes to the occurrence of female cystitis, at this time bacteria penetrate the body more easily, immunity is weakened, hygiene rules may not be observed. Palin will help in case of female cystitis.

The drug is also used to prevent possible infections during instrumental urological and gynecological implants.

Release form

Palin is produced in the following forms:

• capsules filled with white powder (200 mg), packaged in 10 pieces in a blister;
• coated tablets (400mg);
• vaginal suppositories (200 mg).

Pharmacodynamics

Palin belongs to the quinolones of a wide spectrum of antibacterial orientation. It is especially effective against gram-negative bacteria and, to a lesser extent, gram-positive ones: pipemidic acid destroys their DNA. Anaerobic microorganisms are not affected by it.[1]

Pharmacokinetics

The bioavailability of the drug sometimes reaches 60%. The highest concentration of the active substance is localized in the kidneys, urine, prostate gland. In plasma, its peak occurs 1-2 hours after ingestion. Most of it is excreted from the body through the urinary organs.[2]

Dosing and administration

Usually, with cystitis, palin is drunk for 5-10 days, at the discretion of the doctor, the course is extended to 4 weeks. Uncomplicated disease can be treated within 3 days. Women have the opportunity to treat urinary tract infections in parallel with pills and also with the help of suppositories. Within a week, one suppository is placed at night.

• Application for children

Palin can be used by children from the age of 14. Pipemidic acid leads to muscle hypertonicity, and also accumulates in cartilage, which is an obstacle to its use at an earlier age.

Use Palina with cystitis during pregnancy

The effect of the drug on the fetus has not been properly studied. The lack of epidemiological data gives reason not to recommend it for use in pregnant women. When breastfeeding and the need to be treated with palin, it is better to stop lactation for a while.

Contraindications

In addition to the above prohibitions on the use of palin, it cannot be prescribed for allergies to components, suffering from epileptic seizures, other neurological diseases that cause convulsions, severe pathologies of the kidneys and liver, and cerebrovascular accidents. The drug requires caution in the use of people over 70 years of age.

Side effects Palina with cystitis

Palin is generally well tolerated by patients and has no major complaints about side effects. Among the possible negative manifestations of treatment are nausea, vomiting, epigastric pain, tremor, convulsions, nervous excitement, depression, headaches, insomnia.

Overdose

Exceeding the recommended doses can cause overdose symptoms: dizziness, vomiting, sometimes even loss of consciousness. If the patient is able to induce vomiting, gastric lavage should be done immediately. The active substance is excreted from the body by hemodialysis in 6 hours.

Interactions with other drugs

Palin slows down the action of theophylline, increases the concentration of caffeine and enhances the therapeutic effect of non-steroidal anti-inflammatory drugs, warfarin, cimetidine, rifampicin. Drugs that neutralize the acidity of the stomach and sucralfate, which is used for gastric and duodenal ulcers, reduce its absorption.

Storage conditions

The drug is stored in a dry, dark place and out of the reach of children. The air temperature in the room should not exceed +25ºС.

Shelf life

Shelf life - 5 years, after which it is subject to disposal.

Analogues

To combat cystitis, there are a large number of drugs that are analogous to palin: uropimid, urotractin, pipegal (with the same active ingredient); amoxisar, biseptol, gentos, indomethacin, nolicin, furadonin (based on other components, but with the same therapeutic effect).

Reviews

Palin, according to reviews, is an effective remedy for the treatment of cystitis, he helped many patients get rid of unpleasant and painful symptoms, relieved inflammation. Even some pregnant women had to use it in combination with other therapeutic drugs.