Texol

Texol is a hormone antagonist and a drug that slows the activity of enzymes.

Indications Texola

It is used to treat a common form of breast cancer in postmenopausal women (except for women with estrogen-negative cancer) if they have not previously had a positive reaction to tamoxifen.

Release form

Release of the medication occurs in tablets, in an amount of 7 pieces inside the blister pack. The box contains 4 such packages.

Pharmacodynamics

Anastrozole is a non-steroid-type selective element that slows the activity of aromatase. During postmenopause, the formation of estradiol occurs mainly with the participation of estrone produced by peripheral tissues, by transformation from androstenediol. The enzyme aromatase is involved in this process.

Decreased estradiol results in the development of medicinal effects in women with breast cancer. During the postmenopause, the anastrozole component in a dose of 1 g per day leads to a decrease in the values of estradiol by 80%.

The drug does not possess an androgenic, progestagenic, and estrogenic effect and does not affect the release of aldosterone with cortisol in therapeutic portions.

Pharmacokinetics

With the use of drugs inside, it is quickly absorbed inside the gastrointestinal tract. Peak values within the blood plasma are noted after 2 hours (when taken on an empty stomach). Food slightly reduces the absorption rate, without affecting its degree. The synthesis of a substance with a protein in the plasma is 40%. There is no information on the cumulation of the drug.

Exchange processes of LS proceed with the participation of N-dealkylation, glucuronization and hydroxylation. The main product of disintegration is triazole, which does not lead to a slowing down of aromatase activity.

Anastrozole together with its metabolic products is excreted mostly in urine (less than 10% of them have unchanged form), during 72 hours after single use. Half-life is about 40-50 hours.

Dosing and administration

Texol is prescribed for adult women - for oral use, 1 mg once a day.

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Use Texola during pregnancy

Prescribe Texol to pregnant women - it is contraindicated.

Contraindications

The main contraindications:

• women who did not start menopause;
• kidney failure in severe degree (CC level is less than 20 ml / min);
• women breastfeeding;
• the presence of hypersensitivity against anastrozole;
• Insufficiency of the liver.

Side effects Texola

The use of medication can provoke various side effects, manifested with varying frequency.

In most cases, reactions that affect vascular activity develop, such as sudden flushing of blood to the skin of the face, often with a mild or moderate degree of severity.

Often there are such signs:

• systemic: a feeling of fatigue or asthenia;
• disorders affecting the function of ODA: muscle rigidity or pain, and in addition the risk of fracture of the bones;
• abnormalities in the functioning of the mammary glands or reproductive organs: dryness of the vaginal mucosa (usually of moderate severity);
• damage to the epidermis or its appendages: a moderate form of alopecia;
• problems with the activity of the digestive tract: the appearance of diarrhea or nausea;
• disturbances in the function of the NA: a feeling of excitement or anxiety, headaches and carpal tunnel syndrome;
• damage to the visual organs: the development of cataracts;
• disorders in the work of SSS: the development of myocardial infarction, ischemic heart disease or angina pectoris;
• disorders of the hepatobiliary system: an increase in the values of liver enzymes - such as ALT with AST and AF.

Sometimes the following disorders occur:

• lesions in the mammary glands or reproductive organs: bleeding from the vagina (often in patients with breast cancer in progressive form - during the first few weeks in the period after the change of treatment with hormone therapy for the drug with anastrozole);
• metabolic and metabolic disorders: the development of anorexia (mainly to a moderate extent). The total cholesterol index may also increase slightly;
• disorders of the function of the digestive tract: the emergence of vomiting;
• symptoms associated with the work of the National Assembly: a feeling of drowsiness;
• lesions affecting the hepatobiliary system: development of hepatitis or an increase in the values of GGT and bilirubin;
• violations of the function of CCC: any complications of thromboembolic nature in the veins, and in addition, vascular ischemia in the brain.

Occasionally the following manifestations are noted:

• lesions affecting the work of the CAS: ischemia in the myocardium or coronary arteries;
• disorders in the epidermis with its appendages: Stevens-Johnson syndrome or polyformiform erythema;
• other disorders: allergy symptoms, including hives, Quincke edema and anaphylaxis;
• disorders of reproductive activity and functions of the mammary glands: cancer in the endometrium.

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Interactions with other drugs

The drug weakens the medicinal properties of estrogens in case of its combination with them.

Information taken from clinical tests shows that with the combination of Texol with cimetidine or antipyrine, the likelihood of developing therapeutic interaction associated with the induction of microsomal hepatic enzymes is very low.

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Storage conditions

Teksol should be kept in a place that is closed from children, at temperatures below 25 ° C.

Shelf life

Texol can be used for 2 years from the date of manufacture of the therapeutic agent.

Use in children

It is forbidden to use medicines for children.

Analogues

Analogues of the drug are drugs Aksastrol, Aktastrozol, Anastora, Anastrozole, Anatero, Arimidex, Armotraz, Aromazine, Lezra, Letorap, Letrozol, Letromara, Letrotera, Mammozol, Nexazolum, Fehmara, Femiset, Egistrozol, Exemestan, Enzamidek, Etruzil.