Teveten

Teveten is a drug against high blood pressure with the international name Elprostan.

Indications Tevetena

The reason for prescribing Teveten is low blood pressure of the essential form.

Release form

The medicine is available in tablets. Teveten is available in two dosages, fourteen pieces per blister. Each package contains detailed instructions, as well as 1, 2 or 4 tablets.

Pharmacodynamics

Teveten is a medicine that reduces blood pressure, an antagonist of angiotensin II receptors. Forming a strong union and subsequent dissociation, Elprostan selectively affects AT1 receptors, the anatomical location of which is in the heart, blood vessels, adrenal cortex and kidneys.
Showing a vasodilating effect, Elprostan significantly reduces the effect of angiotensin II. In addition, it reduces arterial vasoconstriction, OPPS, absorption of water and sodium in the nearest section of the renal canals, as well as the secretion of aldosterone.
Without showing any effect on the occurrence of low pressure of the orthostatic type in response to taking the initial dose, the drug nevertheless retains its effectiveness throughout the day.
A stable antihypertensive effect occurs after two to three weeks of continuous use. In blood tests on an empty stomach, in patients regularly taking Teveten, no effect on the increase or decrease in the concentration of cholesterol and glucose was revealed.
Maintains renal autoregulation, reduces the excretion of blood proteins, thereby exerting a nephrotoxic effect.
Has virtually no effect on purine metabolism.
Does not cause withdrawal syndrome if you stop taking Tevoten.

Pharmacokinetics

The bioavailability of Teveten, immediately after taking the drug in a single dose, will be about thirteen percent. The highest concentration will be reached in one and a half to two hours after the start of taking the drug. Regardless of gender and liver function, the connection of Teveten with serum proteins will be high (about 98%). This connection will remain at the same high level after reaching the maximum values of the drug density. It will not change in patients with mild or moderate renal impairment, but will decrease with severe renal impairment. A slight decrease (by 25%) in adsorption will occur due to food intake.
The half-life will be about five to nine hours.
Ninety percent of the drug is excreted through the intestines, and seven percent by the kidneys. At the same time, very little (about two percent) is excreted by the kidneys in the form of glucuronides. In the analysis of urine concentration, it is clearly visible that twenty percent is acyl glucuronide, and eighty is an unchanged drug.
The drug practically does not accumulate in the human body.
The pharmacokinetics of the drug is not affected by the patient's body weight, gender or race. Studies have not been conducted in patients under the age of eighteen.
In elderly people, the concentration in the body Teveten increases approximately twice, but this does not require dosage adjustment.
Use during pregnancy
If it is vital for a nursing mother to take Teveten, breastfeeding should be stopped immediately, since there is no data on the possible penetration of the active ingredient into breast milk.

Teveten should not be taken during the gestation period, especially in the second and third trimesters. Patients with an established pregnancy or planning it should immediately, if they have exceptional vital indications for taking Tenoten, switch to other drugs with an antihypertensive effect, but with an established fact of the possibility of use during the period of bearing a child.
It is an established fact that Teveten has a toxic effect on the fetus (for example, kidney function decreases, oligohydramnios occurs, the fetus experiences a delay in ossification of the bones of the skull). Therefore, if the attending physician insists on treatment with Teveten in the second half of pregnancy, it is necessary to regularly monitor the state of the fetus's kidney and skull function using ultrasound. Infants whose mothers used Teveten may have an increased potassium content in body, renal failure and low blood pressure. Therefore, they should be carefully examined for hypotension and other pathologies.

Dosing and administration

Tenoten tablets should be taken orally. The drug can be used regardless of food intake, since food has no effect on the pharmacodynamics of the drug.
The required dosage of the drug is determined by the attending physician, on average, the daily dose does not exceed 0.6 mg.
Elderly people, as well as those with renal insufficiency, do not need to change the dosage. However, such patients should not be prescribed more than 0.6 mg per day.
The drug can be used for a long time, but the period of taking the tablets is also determined by the doctor.

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Contraindications

Absolute contraindications for the administration of Tevoten are:

• personal intolerance to the active components of the drug;
• gestational period;
• breastfeeding;

It is worth considering all the risks when prescribing Teveten in the following cases:

• diarrhea;
• narrowing of the lumen of the renal arteries of one or both kidneys;
• decreased BCC;
• severe myocardial insufficiency.

Side effects Tevetena

During the period of taking the medication, the following undesirable effects may occur:

• dizziness;
• skin rash and itching;
• low blood pressure;
• facial swelling;
• anginal edema;
• muscle weakness;

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Overdose

Available information about the drug shows that it is well tolerated. Studies have shown that a daily dose of up to 1200 mg is effective for two months and that there is no dependence of the occurrence of side effects on the dose of the drug.
Therefore, there is practically no data on cases of excessive intake of the drug.
Compatibility:
When using Teveten together with certain drugs, it should be taken into account that:

• with lithium preparations: Tenoten increases the concentration of lithium in the blood serum;
• with Veropamil: there is an increase in the hypotensive effect;
• with Nifedipine - significant reduction in blood pressure;
• with adsorbents – the absorption of Teveten will be significantly reduced;
• with Hydrochlorothiazide, Chlorothiazide - increase in the effect of diuretics

Storage conditions

Mandatory conditions for storing the medicinal form are: temperature up to 25°C, a place inaccessible to children and animals, and ensuring the absence of high humidity.

Special instructions

Reviews
The medicine is prescribed by the attending physician for the treatment of high blood pressure. There are either no side effects at all, or they are expressed to a small degree and pass almost immediately. The effect of taking the drug will be noticed immediately. It is worth strictly following the recommendations given by the doctor.

Shelf life

The shelf life of Tenoten depends on its dosage, so at a dose of 600 mg the shelf life will be three years, and 400 mg – two years. The drug should not be used longer than the period indicated on the packaging.