Teveten

Teveten - a remedy against hypertension with an international name - elprostan.

Indications of the tevetena

The reason for the prescription of Teveten is a reduced pressure of the essential form.

Release form

The medicine is available in tablets. Teveten exists in two dosages, fourteen pieces per blister. Each package contains detailed instructions, as well as 1, 2 or 4 plates.

Pharmacodynamics

Teveten is a pressure-reducing medication, an angiotensin II receptor antagonist. Forming a strong alliance and subsequent dissociation, Elprostan selectively affects the AT1 receptor, the anatomical location of which in the heart, vessels, adrenal cortex and kidneys.
Using a vasodilating effect, Elprostan significantly reduces the effect of angiotensin II. In addition, it reduces arterial vasoconstriction, OPPS, absorption of water and sodium in the nearest department of the kidney channels, as well as the secretion of the secretion of aldosterone.
Without showing any effect on the appearance of an orthostatic type of reduced pressure in response to the initial dose, the drug nevertheless remains effective throughout the day.
Stable anitigiperthetic effect occurs after two to three weeks of constant admission. In blood tests on an empty stomach, patients who regularly use Teveten did not show any effect on increasing or lowering the concentration of cholesterol and glucose.
Preserves autoregulation of the kidneys, reduces the excretion of blood proteins, thereby exerting a nephrotoxic effect.
It has almost no effect on purine metabolism.
Does not cause withdrawal syndrome if you stop taking Tevoten.

Pharmacokinetics

The bioavailability of Teveten, immediately after consuming the drug in a single dose, will be about thirteen percent. The highest concentration level will reach one and a half to two hours after the start of taking the medicine. Regardless of sex and liver function, Teveten's binding to serum proteins will be large (about 98%.) This relationship will remain at the same high level after reaching the maximum values of the drug's density.It will not change in patients with mild or moderate renal damage, but decrease with their severe damage.A small decrease (by 25%) of adsorption will occur due to food intake,
About five to nine hours will be half
-life.Ninety percent of the drug is excreted by the intestine, and seven percent In the urine concentration analysis, it is clearly seen that twenty percent is acylglucuronide, and eighty is an unchanged drug.The
Drug is practically not accumulated in the human body.The
Pharmacokinetics of the drug does not affect the patient's body weight, nor his gender or race.In patients who are under the age of eighteen, no studies have been conducted.
In elderly people, the concentration in the body of Teveten is approximately doubled, but this does not require a dosage adjustment.
Use during pregnancy
With the vital necessity of taking Teveten's medication with a nursing mother, breastfeeding of the baby should be stopped immediately, as there is no data on the possible penetration of the active ingredient into breast milk.

You can not take Teveten in the gestational period, especially in the second and third trimester. Patients with an established pregnancy or planning it should immediately, if for taking Tenoten they have exceptional life indications, switch to other medicines with antihypertensive effect, but with the established fact of the possibility of application in the period of bearing the child.
The established fact that Teveten has a toxic effect on the fetus (for example, kidney function decreases, there is a lack of water, the fetus has a delay in ossification of the skull bones). Therefore, if the attending physician insists on Teveten treatment in the second half of pregnancy, ultrasound should be regularly monitored for the condition of the fetus in the kidneys and the skull. In infants whose mothers used Teveten, there may be an increased presence of potassium in the body, kidney failure and low blood pressure. Therefore, they must be scrupulously examined for the detection of hypotension and other pathologies.

Dosing and administration

Tenoten tablets should be taken orally, orally. The drug can be used regardless of eating food, because the pharmacodynamics of the drug does not have any effect.
The required dosage of the medicine is determined by the attending physician, on average the daily dose does not exceed 0.6 mg.
For older people, as well as kidney failure, dosage adjustment is not required. However, such patients should not prescribe more than 0.6 mg per day.
The drug can be used for a long time, but the period of taking the tablets is also determined by the doctor.

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Contraindications

Absolute contraindications for the appointment of Tevoten are:

• personal intolerance of the active components of the drug;
• gestational period;
• lactation;

It is worth considering all the risks when appointing Teveten in the case of:

• diarrhea;
• narrowing of the lumen of the renal artery of two or one kidney;
• lowered BCC;
• severe degree of myocardial insufficiency.

Side effects of the tevetena

During the period of drug use, such undesirable effects may occur:

• dizziness;
• skin rash and overgrazing;
• low pressure;
• swelling of the face;
• anginaervotive edema;
• muscle weakness;

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Overdose

The available information on the drug shows that it is well tolerated. The carried out researches allow to inform about efficiency of a daily dose to 1200 mg during two months and absence of any dependence of occurrence of a side effect from a dose of a medicine.
Therefore, there are practically no data on cases of excessive intake of the drug in the body.
Compatibility:
When sharing Tevetin with certain medicines, it should be noted that:

• with lithium preparations: Tenoten increases the concentration of lithium in the blood serum;
• with Veropamil: there is an increase in hypotensive action;
• with Nifedipin - a significant reduction in blood pressure;
• with adsorption - Teveten absorption will be significantly reduced;
• with Hydrochlorothiazide, Chlorothiazide - an increase in the action of diuretics

Storage conditions

Obligatory conditions for storage of the dosage form are: temperature up to 25 ° C, a place that is inaccessible to children and animals, as well as ensuring the absence of high humidity.

Special instructions

The
Medicine is prescribed by the attending physician for the treatment of hypertension. Side effects are either completely absent, or they are expressed in a small degree and almost immediately pass. The effect of taking the drug will be immediately noticed. It is necessary to adhere strictly to the recommendation that the doctor gave.

Shelf life

The storage time of Tenoten depends on its dosage, so in a dose of 600 mg - the storage period will be three years, and 400 mg - for two years. Do not take the drug more than the specified packaging period.