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Testosterone in the blood

 
, medical expert
Last reviewed: 31.05.2018
 
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Testosterone is an androgenic hormone responsible for secondary sexual characteristics in men. The most important source of testosterone is Leidig cells of the testes. Testosterone supports spermatogenesis, stimulates the growth and function of additional sexual glands, as well as the development of the penis and scrotum. The hormone has an anabolic effect, mainly in relation to bones and muscles. Due to direct effects on the bone marrow, as well as by activating the synthesis of erythropoietin in the kidneys, testosterone stimulates erythropoiesis. A hormone is also needed to maintain libido and potency. The synthesis of testosterone is controlled by the LH of the anterior lobe of the pituitary gland. In men, this is the main androgen, which determines the achievement of sexual maturity. The concentration of the hormone in the blood increases after exercise. The reference values of serum testosterone concentration are given in Table. 9-28.

In adult healthy men, peak testosterone concentrations occur in the morning and decrease by at least 25% in the evening. After 50 years, there is a progressive decrease in testosterone in the blood.

The concentration of testosterone in the blood serum increases with idiopathic premature puberty and hyperplasia of the adrenal cortex in boys, tumors of the adrenal cortex, extragonadal tumors in men, in diseases of trophoblast in pregnant women, and arrenoblastomas.

Reduction of testosterone concentration in the blood is noted with Down's syndrome, delayed puberty.

Reference values (norm) of testosterone concentration in blood serum

Age

Floor

Testosterone

Ng / dL

Nmol / l

Newborns

Male

75-400

2.6-13.9

 

Women's

20-64

0.69-2.22

Prepubertal age:

1-5 months

Male

1-177

0.03-6.14

 

Women's

1-5

0.03-0.17

6-11 months

Male

2-7

0.07-0.24

 

Women's

2-5

0.07-0.17

1-5 years

Male

2-25

0.07-0.87

 

Women's

2-10

0.07-0.35

6-9 years

Male

3-30

0.10-1.04

 

Women's

2-20

0.07-0.69

Pubertal age:

1 age group

Male

2-23

0.07-0.80

 

Women's

2-10

0.07-0.35

2 age group

Male

5-70

0.17-2.43

 

Women's

5-30

0.17-1.04

3 age group

Male

15-280

0.52-9.72

 

Women's

10-30

0.35-1.04

4 age group

Male

105-545

3.64-18.91

 

Women's

15-40

0.52-1.39

5 age group

Male

265-800

9.19-27.76

 

Women's

10-40

0.35-1.39

Adults

Male

280-1100

8.72-38.17

 
Women's

15-70

0.52-2.43

Pregnant
3-4 times higher than usual concentration
Postmenopause
8-35
0.28-1.22

Approximately 2% of testosterone circulating in the blood is in a free state. Only free testosterone is able to penetrate the cell, bind to intracellular receptors, penetrate the nucleus and change gene transcription (that is, ultimately to realize its biological effects).

Reference values (norm) of concentration of free testosterone in blood serum

Floor

Free testosterone

Age

Pg / ml

PMol / l

Newborns

Male

1.5-31

5.2-107.5

 

Women's

0.5-2.5

1.7-8.7

1-3 months

Male

3.3-8

11.5-62.7

 

Women's

0.1-1.3

0.3-4.5

3-5 months

Male

0.7-14

2.4-48.6

 

Women's

0.3-1.1

1.0-3.8

5-7 months

Male

0.4-4.8

1.4-16.6

 

Women's

0.2-0.6

0.7-2.1

Children:

6-9 years

Male

0.1-3.2

0.3-11.1

 

Women's

0.1-0.9

0.3-3.1

10-11 years old

Male

0.6-5.7

2.1-9.8

 

Women's

1.0-5.2

3.5-18

12-14 years old

Male

1.4-156

4.9-541

 

Women's

1.0-5.2

3.5-18

15-17 years old

Male

80-159

278-552

 

Women's

1-5.2

3.5-18

Adults

Male

50-210

174-729

 

Women's

1.0-8.5

3.5-29.5

Free testosterone is independent of the concentration of SSH. Therefore, the determination of free testosterone is indicated in those situations when the content of the SSH may increase (hyperthyroidism, hyperestrogenism, pregnancy, intake of oral contraceptives or antiepileptic drugs) or decrease (hypothyroidism, obesity).

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