Tebantin

A medication characterized by antiepileptic, analgesic (against the background of damage to the glomeruli and renal parenchyma) and neuroprotective mechanisms of action.

Indications Tebantina

Tebantin can be prescribed for use by a group of patients who suffer from epilepsy.
Thus, for children (from three to twelve years old) Tebantin is actively used in the treatment regimens for individual attacks.
There is no data on the possible use of the drug in the treatment of up to three years.
Tebantin can already be prescribed to children from twelve years old and adults not only in the context of auxiliary, but also monotherapy of epileptic partial attacks.
There is no information on the use of the drug before the age of twelve only this drug.
In addition, the drug is effective for pain of a neurotic nature, and for damage to the glomeruli and renal parenchyma.

Release form

The medicine comes in capsule form, containing 100, 300 or 400 mg of active substance. Each box contains fifty or one hundred pieces.

[ 1 ]

Pharmacodynamics

Tebantin does not interact with GABA and GABA receptors.
Studies show that new peptide receptors have been discovered in brain tissue, and by acting on them the medication can exert an anticonvulsant effect.

Pharmacokinetics

The highest concentration of the drug is reached three hours after the first dose. If you take the tablet again, the concentration will be reached three hours faster. The bioavailability of Tebantin, on the contrary, will decrease with increasing dosage. It can be up to 60%. The patient's consumption of food that contains a lot of fat will increase such pharmacokinetic characteristics as AUC and maximum concentration, but will not affect the absorption of the drug.
The increase in these indicators occurs proportionally to the increase in dosage.
The density of the drug in the blood serum of children from four to twelve years old is similar to that of adult patients. The same condition was observed with further use of the drug and remained stable throughout the course of therapeutic treatment.
Gabaptine does not enhance liver enzymes and is almost not metabolized in the human body.
The drug almost does not react with plasma proteins, but passes through the BBB and gets into breast milk.
The half-life is determined by the amount of the active substance taken (about seven hours). Excretion occurs unchanged by the kidneys. Hemodialysis will remove residual drug from the serum.

Dosing and administration

The medicine should be taken exclusively orally, without chewing. A mandatory condition, if the attending physician has prescribed more than one dose per day, is to observe a time interval of no more than twelve hours.
Therapy regimens with Tebantin are determined by the pathological condition for which it is prescribed:
1. Partial seizures
Used in therapy for children from 12 years of age and adults. The maximum effect is achieved in a couple of days, when using doses from 900 to 1200 mg per day.
Treatment by day:
One day - 300 mg per day
Two days - 600 mg per day
Three days - 900 mg per day
From the fourth day - 1200 mg per day
It is advisable to divide the dosage into three doses. Another regimen also starts with 300 mg/day, but from the second day it can be increased to 1200 mg and, with normal effectiveness, increased by 300-400 mg daily, but not more than 2400 mg per day (due to insufficient safety information).
For children from three years of age, the initial treatment regimen is indicated in the table:

Child's weight, kg	Dose, mg	Day 1, mg/day	Day 2, mg, 2 times a day	Day 3, mg, 3 times a day
17–25	600	200	200	200
≥26	900	300	300	300

For maintenance therapy, children weighing more than 17 kg can use the following doses:

Weight, kg	Total dose, mg/day
17–25	600
26–36	900
37–50	1200
51–72	1800

2. Nephropathy in patients over eighteen years of age.
The dosage is strictly controlled by the doctor and depends on the patient's condition and the effectiveness of the treatment. In this case, it can reach its highest value of 3600 mg per day.
Description of the treatment procedure:
One day - 300 mg per day
Two days - 600 mg per day
Three days - 900 mg per day
You can also use a therapy in which the dose will be 900 mg on the first day, and then over the course of seven days it can be increased to 1800 mg per day.
In exceptional circumstances, the dosage can be immediately increased to 3600 mg per day (in three doses). Thus, in the first week of therapy - up to 1800 mg, the second - up to 2400 mg, and from the third week reach 3600 mg per day.
If the patient is too weak, the dose can be increased by no more than 100 mg per day.

For patients undergoing the procedure of blood purification outside the kidney, taking Gabapeptin (on days without the procedure) is prohibited. The initial dose is approximately 300-400 mg, and then every four hours of the procedure is 200-300 mg.
Overdose
If a patient taking Tebantin complains of lethargy, double vision, then he has all the signs of drug intoxication. But it is worth noting that even after taking 49 g of the drug, an overdose of Tebantin did not threaten the patient's life.
In case of severe poisoning with Gabapeptin or severely reduced renal function, hemodialysis is required.

[ 2 ], [ 3 ]

Use Tebantina during pregnancy

Studies show that Gabapeptin passes into breast milk, so due to the potential threat of severe adverse reactions in newborns, breastfeeding should be discontinued.
The use of the drug during the gestational period is possible only after a scrupulous discussion of all acceptable threats and the positive effect of therapy. This is explained by the fact that there is no information on the use of the drug at this time.

Contraindications

The medicine should not be used during breastfeeding, in case of acute inflammation of the pancreas, or in case of individual hypersensitivity to the components of Tabentin.

Side effects Tebantina

During the course of therapy, the following side effects may occur:

• tremor,
• dry mouth and throat,
• anorexia
• excess weight
• hyperemia of the skin, itching, appearance of rashes,
• aggressiveness.

Interactions with other drugs

When Tebantin is used in combination with certain medications, the following reactions are possible:

• Antiepileptic drugs (Carbamazepine, Phenytoin): no reaction.
• Oral contraceptives: do not cause reactions unless used in combination with other antiepileptic drugs.
• Antacids: Gabapeptin should be taken only two hours after taking medications that contain magnesium or aluminum, and, in addition, neutralize increased acid in the stomach. Since the bioavailability of Tebantin will be greatly reduced (by 24%).
• Cimetidine: reduces the ability of Gabapeptin to be excreted.
• Morphine: When taken in capsule form two hours before Tebantin, the AUC of Gabapetin increased by 44%. This resulted in an increase in pain sensitivity. However, Gabapetin did not change the pharmacokinetics of Morphine.
• Alcohol: Increases the drowsiness effect.

[ 4 ], [ 5 ]

Storage conditions

The main storage conditions for Tebantin are: maintaining a temperature of no higher than 25°C, and a place inaccessible to children.

Special instructions

Reviews
The drug should be taken only as prescribed, starting therapy with a smaller dose, gradually increasing it. This is a fairly effective remedy, with a strong mechanism of action. The main condition is to follow all the recommendations given by the attending physician.

[ 6 ], [ 7 ]

Shelf life

Do not use the product after five years from the date of manufacture.

[ 8 ]