Tebantin

A medication for which characteristic antiepileptic, analgesic (against a background of lesions of glomeruli and parenchyma of the kidneys) and a neuroprotective mechanism of action are characteristic.

Indications of the tebantin

Tebantine can be prescribed for use by a group of patients who suffer from epilepsy.
So, for children (from three to twelve years old) Tebantin is actively used in therapy regimens for individual seizures.
These possible use in the treatment of drugs up to three years there.
Children with twelve years and adults Tebantin can already be prescribed not only in the context of ancillary, but also monotherapy of epileptic partial seizures.
Information on the use of a medicinal product before the age of twelve is not available only with this drug.
In addition, the drug is effective for pain of a neurotic nature, and in the defeat of glomeruli and parenchyma of the kidneys.

Release form

Form of drug capsules containing 100,300 or 400 mg of active substance. In each box there are fifty or one hundred pieces.

[1]

Pharmacodynamics

Tebantin does not interact with the GABA and GABQC receptors.
Studies show that new peptide receptors have been found in the brain tissues, acting on which the medication can exhibit an anticonvulsant effect.

Pharmacokinetics

The highest concentration of medication reaches three hours after the first dose. If you take the pill again, achieving concentration will happen three hours faster. Bioavailability of Tebantine, on the contrary, will decrease with increasing dosage. Maximum it can be about 60%. The patient's intake of food that contains many fats will increase such pharmacokinetic characteristics as AUC and maximum concentration, but does not affect the assimilation of the drug.
The increase in these indices is proportional to the increase in dosage.
The density of the drug in the blood serum in children from four to twelve years is similar to the adult category of patients. The same condition was observed with the further use of the medication and remained stable throughout the course of therapeutic treatment.
Gabapeptin does not enhance liver enzymes, and is hardly metabolized in the human body.
The drug almost does not react with plasma proteins, but passes through the BBB and enters the mother's milk.
The half-life is due to the amount of active ingredient taken (about seven hours). Isolation occurs unchanged in kidneys. Hemodialysis will remove the remnants of the drug from the serum.

Dosing and administration

The medication should only be taken orally, orally, without chewing. A prerequisite, if the attending doctor has prescribed more than one dose per day, is to observe a time interval of not more than twelve hours.
Therapy regimens Tebantinom caused by the pathological condition in which it is appointed:
1. Sudogrs of a partial nature
Used in therapy in children from 12 years of age and adult. The maximum effect is achieved in a couple of days, with the use of doses from 900 to 1200 mg a day.
Treatment by day:
One day - 300 mg per day
Two days - 600 mg per day
Three days - 900 mg per day
From the fourth day - 1200 mg per day.
Dosage should be divided into three divided doses. Another scheme starts also with 300 mg / day, but already from the second day it can be increased to 1200 mg and, at normal efficiency, increased by 300 to 400 mg daily, but not more than 2,400 mg per day (due to insufficient safety information ).
Children with a three-year initial scheme of treatment is indicated in the table:

Weight, kg	Dose, mg	1st day, mg / day	2nd day, mg, 2 times a day	3rd day, mg, 3 times a day
17-25	600	200	200	200
≥26	900	300	300	300

As a supportive therapy for children weighing more than 17 kg, doses can be used:

Weight, kg	Total dose, mg / day
17-25	600
26-36	900
37-50	1200
51-72	1800

2. Nephropathy in patients from the age of eighteen.
Dosage is strictly controlled by the doctor and depends on the patient's condition and the effectiveness of the treatment. At the same time, it can reach a maximum value of up to 3600 mg per day.
Description of treatment:
One day - 300 mg per day
Two days - 600 mg per day
Three days - 900 mg per knock
You can also apply therapy, in which the first day the dose will be 900 mg, and then for seven days it can be increased to 1800 mg per day.
In exceptional circumstances, the dosage can immediately be increased to 3600 mg per day (for three doses). So, in the first week of therapy - up to 1800 mg, the second - up to 2,400 mg, and from the third week to reach a rate of 3600 mg per day.
If the patient is too weak, the dose can be increased by no more than 100 mg per day.

For patients who undergo the procedure for blood purification outside the kidney, gabapeptin (on days without procedure) is prohibited. The initial dose is approximately 300 to 400 mg, and then every four hours of the procedure is 200 to 300 mg.
Overdose
If the patient who takes Tebantin, complains of lethargy, double vision, then he has all the signs of administration of the drug. But it is worth replacing that even after taking 49 g of medication, an overdose of Tebantin did not threaten the life of the patient.
With severe poisoning with Gabapeptin or a pronounced impaired renal function, hemodialysis is required.

[2], [3]

Use of the tebantin during pregnancy

Studies show that Gabapeptin enters the mother's milk, therefore, because of the potential threat of severe adverse reactions in newborns, breastfeeding should be discontinued.
The use of medication in the gestational period is possible only after a scrupulous discussion of all permissible threats and the positive effects of therapy. This is because there is no information about the use of the drug at this time.

Contraindications

The medicine can not be used during the breastfeeding period, with acute inflammation of the pancreas, and also in the case of individual individual sensitivity to the components of Tabentin.

Side effects of the tebantin

During the passage of therapy, there may be such adverse reactions as:

• tremor,
• dry mouth and throat,
• anorexia
• excessive completeness
• hyperemia of the skin, overgrazing, the appearance of rashes,
• aggressiveness.

Interactions with other drugs

With the joint use of Tebantine with certain drugs, the following reactions are possible:

• Preparations against epilepsy (carbamazepine, phenytoin): no reaction.
• Oral contraceptives: do not react, unless they combine their use with another antiepileptic.
• Antacids: it is worth using Gabapeptin only two hours after consuming drugs that contain magnesium or aluminum, and, in addition, neutralizing the increased acid in the stomach. Since the bioavailability of Tebantin is very low (by 24%).
• Cimetidine: The ability of Gabapeptin to release is reduced.
• Morphine: if it is in the form of capsules used two hours before Tebantin, there is an increase in AUC by 44% of Gabapeptin. As a result, there was an increase in pain sensitivity. In this case, Gabapetin did not change Morphine's pharmacokinetics.
• Alcohol: increased drowsiness effect.

[4], [5]

Storage conditions

The main conditions for storing Tebantin are: compliance with the temperature regime is not higher than 25 ° C, and also a place in which there is no access for children.

Special instructions

Reviews
The drug should be taken solely for the intended purpose, starting therapy with a smaller dose, gradually increasing it. This is a fairly effective tool, with a strong mechanism of action. The main condition is to follow all the recommendations given by the doctor in charge.

[6], [7]

Shelf life

Do not use the drug after a five-year period from the date of manufacture.

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