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Tazid
Last reviewed: 23.04.2024
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Tazid is a systemic β-lactam antibiotic of the cephalosporin series, the active component of which is represented by ceftazidime.
Indications Tazid
Antibiotic Tazid is usually prescribed for the treatment of combined and monoinfectious diseases, which were provoked by the action of drug-sensitive bacteria. Antibiotic is used in such cases:
- with complicated infectious lesions (sepsis, peritonitis, bacteremia, meningoencephalitis, with infected wounds);
- with bacterial diseases of the lungs;
- in bacterial diseases in otolaryngology;
- with infectious diseases of the urinary system;
- at infections of integuments and underlying tissues;
- for bacterial diseases of the digestive system;
- with infections of the musculoskeletal system;
- as a prophylaxis of infectious complications during surgical interventions on the prostate.
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Release form
Tazid is available in the form of a powdery substance of white color, used to make an injection solution. One flacon can contain 1 thousand mg or 2 thousand mg of powder.
The active ingredient is ceftazidime, an antibacterial agent of the cephalosporin series.
Pharmacodynamics
Tazid is an antibiotic of a number of cephalosporins, the effect of which is due to the disruption of the production of the cellular microbial wall. The drug shows activity against gram (+) and gram (-) microorganisms, including bacteria resistant to the effects of gentamicin and other aminoglycosides.
The main effect of the drug is directed against such microorganisms:
- pseudomonas, escherichia, klebsiella, protea;
- enterobacteria, cytobacteria, salmonella, shigella, pasturella, acinetobacteria;
- neusheria, staphylococci, micrococci, streptococci;
- peptococci, peptostreptococci, propionobacteria;
- clostridia, fusobacteria, bacteroides.
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Pharmacokinetics
After the / m and / in the injection of the drug the highest level in the bloodstream is observed after 5 - 45 minutes. Therapeutic amounts of the active ingredient in the blood can remain for 8-12 hours after the injection.
The connection with plasma proteins is equivalent to 10%.
The active ingredient is found in bone tissue, heart, bile, sputum and other body fluids.
The drug overcomes the placental barrier and penetrates into breast milk. There is a weak penetration through the unaffected blood-brain barrier.
The metabolism of the drug in the body does not occur. Sufficient and stable concentration of the drug in the bloodstream is observed both after intramuscular and after intravenous administration.
Half-life Tazid - 2 h.
Excretion is carried out through the kidneys and urinary system. Excretion through the gallbladder is insignificant and can be less than 1%.
Dosing and administration
Dosage of the drug Tazid is selected taking into account the degree of disease, microbial resistance, type of infection, as well as individual characteristics of the patient.
For adult patients, the daily amount of the drug can be 1-6 g, divided into 2-3 injections.
In bacterial infections of urine, appoint 0.5-1 g once every 12 hours.
In severe cases, injections of 2-3 g every 12 hours are shown.
In cystic fibrosis, against the background of lung lesions, Pseudomonas aeruginosa is prescribed 100-150 mg / kg of body weight per day, dividing the dose into three injections.
If the drug is used as a prophylaxis for operations on the prostate, then inject 1 g of Tazide simultaneously with the administration of anesthetics. Repeated drug is administered when the catheter is removed.
- Newborns and infants from 2 months of age are administered 25-60 mg / kg / day and 30-100 mg / kg / day, respectively. Dosage is divided into 2-3 injections.
- For the treatment of elderly patients, the amount of the drug should not exceed 3 grams per day.
The tazide can be administered by intravenous or deep intramuscular injection. Intramuscular injection into the outer upper quadrant of the buttock zone and also to the lateral side of the thigh is permissible.
Tazide is bred in virtually any solution intended for intravenous administration. The only exception is a dissolving liquid such as sodium bicarbonate injection.
The resulting diluted product should have a color from yellowish to dark amber, which depends mainly on the degree of concentration of the liquid.
Use Tazid during pregnancy
It is undesirable to use Tazid in pregnant and lactating patients, since the risk of adverse effects of the drug on the baby remains high.
During lactation and simultaneous treatment with Tazid, breastfeeding is recommended to be suspended.
Contraindications
Tazid is not used:
- at high probability of development of an allergic reaction;
- with hypersensitivity to the drug.
It is not recommended to use Tazid in pregnant and lactating patients.
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Side effects Tazid
During the course of treatment with the drug, undesirable side symptoms may appear:
- thrush (in the form of vaginitis or stomatitis);
- thrombocytosis, eosinophilia;
- allergic reaction;
- disorders of consciousness, pain in the head, violation of the sensitivity of the limbs;
- trembling in the limbs, convulsions;
- phlebitis in the injection zone;
- diarrhea, bouts of nausea, abdominal pain, changes in taste, development of colitis;
- jaundice, urticaria;
- a positive test of Coombs (which should be taken into account when analyzing the group affiliation of the patient's blood).
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Overdose
The use of overestimated doses of the drug Tazid usually leads to adverse neurological consequences:
- encephalopathy;
- convulsions;
- coma.
The level of the drug in the bloodstream can be reduced using hemodialysis, or peritoneal dialysis.
Treatment for signs of an overdose is done by prescribing symptomatic medications.
Interactions with other drugs
Storage conditions
Flasks with powder Tazid is stored in dry, darkened rooms, away from children's access. The storage temperature is room temperature.
Freshly prepared solution is stored no more than 24 hours at room temperature, or no more than a week at t ° + 4 ° C.
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Shelf life
Tazid can be stored for up to 2 years in its original packaging.
Attention!
To simplify the perception of information, this instruction for use of the drug "Tazid" translated and presented in a special form on the basis of the official instructions for medical use of the drug. Before use read the annotation that came directly to medicines.
Description provided for informational purposes and is not a guide to self-healing. The need for this drug, the purpose of the treatment regimen, methods and dose of the drug is determined solely by the attending physician. Self-medication is dangerous for your health.