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Tazid
Last reviewed: 03.07.2025
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Tazid is a systemic β-lactam cephalosporin antibiotic, the active component of which is ceftazidime.
Indications Tazid
The antibiotic Tazid is usually prescribed for the treatment of combined and monoinfectious diseases that were provoked by the action of bacteria sensitive to the drug. The antibiotic is used in such cases:
- in complicated infectious lesions (sepsis, peritonitis, bacteremia, meningoencephalitis, infected wounds);
- for bacterial lung diseases;
- for bacterial diseases in otolaryngology;
- in infectious lesions of the urinary system;
- for infections of the skin and underlying tissues;
- for bacterial diseases of the digestive system;
- for infections of the musculoskeletal system;
- as a preventive measure against infectious complications during surgical interventions on the prostate.
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Release form
Tazid is produced as a white powder used to make an injection solution. One bottle may contain 1,000 mg or 2,000 mg of powder.
The active ingredient is ceftazidime, an antibacterial agent of the cephalosporin series.
Pharmacodynamics
Tazid is an antibiotic of the cephalosporin series, the action of which is due to the disruption of the process of production of the microbial cell wall. The drug exhibits activity against gram (+) and gram (-) microorganisms, including bacteria resistant to the effects of gentamicin and other aminoglycosides.
The main action of the drug is directed against the following microorganisms:
- pseudomonads, escherichia, klebsiella, proteus;
- enterobacteria, citrobacteria, salmonella, shigella, pasteurella, acinetobacter;
- Neucheria, staphylococci, micrococci, streptococci;
- peptococci, peptostreptococci, propionobacteria;
- clostridia, fusobacteria, bacteroides.
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Pharmacokinetics
After intramuscular and intravenous injection of the drug, the highest level in the bloodstream is observed after 5-45 minutes. Therapeutic amounts of the active ingredient in the blood can remain for another 8-12 hours after injection.
The binding to plasma proteins is estimated at 10%.
The active ingredient is found in bone tissue, heart, bile, sputum and other body fluids.
The drug crosses the placental barrier and enters breast milk. However, weak penetration through the intact blood-brain barrier is observed.
The drug is not metabolized in the body. Sufficient and stable concentration of the drug in the bloodstream is observed after both intramuscular and intravenous administration.
The half-life of Tazid is 2 hours.
Excretion occurs via the kidneys and urinary system. Excretion via the gallbladder is insignificant and may be less than 1%.
Dosing and administration
The dosage of the drug Tazid is selected taking into account the degree of the disease, the resistance of microbes, the type of infection, as well as the individual characteristics of the patient.
For adult patients, the daily dose of the drug may be 1-6 g, divided into 2-3 injections.
For bacterial infections of the urinary organs, 0.5-1 g is prescribed once every 12 hours.
In severe cases, injections of 2-3 g every 12 hours are indicated.
For cystic fibrosis against the background of lung damage by Pseudomonas aeruginosa, 100-150 mg/kg of body weight per day is prescribed, dividing the dose into three injections.
If the drug is used as a preventive measure during prostate surgery, 1 g of Tazid is administered simultaneously with the administration of anesthetics. The drug is administered again when the catheter is removed.
- Newborns and infants from 2 months of age are administered 25-60 mg/kg/day and 30-100 mg/kg/day, respectively. The dosage is divided into 2-3 injections.
- For the treatment of elderly patients, the amount of the drug should not exceed 3 g per day.
Tasid can be administered by intravenous or deep intramuscular injection. Intramuscular injection into the outer upper quadrant of the gluteal region and into the lateral side of the thigh is acceptable.
Tazid is diluted in almost any solution intended for intravenous administration. An exception is such a dissolving liquid as injectable sodium bicarbonate.
The resulting diluted preparation should have a color from yellowish to dark amber, which depends mainly on the degree of concentration of the liquid.
Use Tazid during pregnancy
It is not advisable to use Tazid for pregnant and lactating patients, as the risk of negative effects of the drug on the child remains high.
During lactation and simultaneous treatment with Tazid, it is recommended to suspend breastfeeding.
Contraindications
Tazid is not used:
- if there is a high probability of developing an allergic reaction;
- in case of hypersensitivity to the drug.
It is not recommended to use Tazid for pregnant and lactating patients.
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Side effects Tazid
During the course of treatment with the drug, the following undesirable side effects may occur:
- thrush (in the form of vaginitis or stomatitis);
- thrombocytosis, eosinophilia;
- allergic reaction;
- disturbances of consciousness, headaches, impaired sensitivity of the extremities;
- trembling in the limbs, convulsions;
- phlebitis in the injection area;
- diarrhea, bouts of nausea, abdominal pain, changes in taste, development of colitis;
- jaundice, urticaria;
- positive Coombs test (which must be taken into account when analyzing the patient's blood group).
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Overdose
Taking excessive doses of the drug Tazid usually leads to adverse neurological consequences:
- encephalopathy;
- convulsions;
- coma.
The level of the drug in the bloodstream can be reduced using hemodialysis or peritoneal dialysis.
Treatment of signs of overdose is carried out by prescribing symptomatic drugs.
Interactions with other drugs
Storage conditions
Vials with Tazid powder are stored in dry, darkened rooms, out of reach of children. Storage temperature is room temperature.
The freshly prepared solution is stored for no more than 24 hours at room temperature, or no more than a week at t° +4°C.
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Shelf life
Tazid can be stored for up to 2 years in its original factory packaging.
Attention!
To simplify the perception of information, this instruction for use of the drug "Tazid" translated and presented in a special form on the basis of the official instructions for medical use of the drug. Before use read the annotation that came directly to medicines.
Description provided for informational purposes and is not a guide to self-healing. The need for this drug, the purpose of the treatment regimen, methods and dose of the drug is determined solely by the attending physician. Self-medication is dangerous for your health.