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Tantum Rose
Medicinal liquid on the basis of Benzidamine - Tantum Rose - has anti-inflammatory effect and is used for the manufacture of intravaginal solution.
Indications of the tantum roses
In what cases is the appointment of Tantum a rose?
- With microbial vaginosis.
- With vulvovaginitis caused by a specific pathogen.
- With vulvovaginitis and cervicitis caused by nonspecific infection.
- To prevent microbial complications before and after surgery.
- To prevent inflammatory complications in the postpartum period.
With specific infectious pathologies, tantum rose is used in combination with other medicines - that is, as part of a combination treatment.
Release form
Tantum rose is produced in the form of granules, which are subsequently used by the patient for the preparation of intravaginal solution.
The active ingredient of the granules is benzydamine g / x.
The cardboard package contains 10 sachets with a granular preparation of Tantum Rose.
- The granular powder has a white color and is homogeneous.
- Intravaginal solution is clear and colorless, has a characteristic pink flavor.
Pharmacodynamics
Tantum rose has antiseptic, anti-inflammatory and analgesic effects.
The active ingredient benzidamine lowers the permeability of the capillary walls, normalizes the lysosomal membranes, inhibits the production of ATP and other high -ergic compounds.
Tantum rose inhibits the production of mediators of the inflammatory process of prostaglandins, bradykinins, cytokine and histamine.
Tantum rose does not affect the synthesis of cyclooxygenase and lipoxygenase, which serves as the prevention of a large number of adverse events.
Tantum rose lowers the receptivity of pain receptors located in the area of inflammation, and also affects the regulation of pain reaction in the centers that are in the thalamus.
The drug has the most vivid antiseptic properties in relation to such a microorganism as Gardnerella vaginalis.
Pharmacokinetics
It was found that the active ingredient of Tantum rose accumulates on the intravaginal epithelium, reaching a peak concentration of 9.7 (± 6.24) μg / g. Slow absorption through the mucosal tissue explains the presence of a small amount of the drug in the serum. Such amounts are considered insufficient to develop systemic drug effects.
The degree of binding to plasma proteins is relatively low and is less than 20%.
The half-life of Tantum Rose is about 13 hours.
The drug is excreted from the body with urinary fluid - in the form of inactive decay products.
Side effects of the tantum roses
In the vast majority of cases, the treatment of Tantum rose is not accompanied by the development of side effects. Very rarely - especially with prolonged use of Tantum Rose - local irritation, hypersensitivity reactions, itching may appear. Even more rarely there is drowsiness, skin rashes.
Dosing and administration
Medication Tantum rose is intended for intravaginal use.
The granular preparation is dissolved in water: one sachet requires 0.5 liters of warm boiled water.
The procedure is carried out on the back, as the solution should remain inside the vagina for several minutes.
- For the treatment of microbial vaginosis, tantum rose is used 1-2 times a day for a week.
- In inflammatory reactions associated with exposure to a nonspecific pathogen, as well as with specific vulvovaginitis, tantum rose is used in the morning and at night for 10 days.
- As a preventive agent, tantum rose is enough to use once a day for 4-5 days.