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Tamsulostad
Urological means - Tamsulostad - is used for benign prostatic hyperplasia. The drug refers to antagonists of alpha 1- adrenergic receptors.
Release form
Tamsulostad is produced in the form of dense capsules, characterized by a modified release.
Capsules are packed in blister plates, 10 pieces in each plate. Cardboard pack contains three plates, which is equivalent to 30 capsules of the drug.
The active ingredient is tamsulosin hydrochloride, the content of which in one capsule is 0.4 mg.
Pharmacodynamics
Tamsulostad belongs to antagonists of alpha 1- adrenoreceptors. The medication arbitrarily inhibits postsynaptic alpha 1- adrenoreceptors located in the smooth muscle structures of the prostate gland, the neck of the ureter and the prostate site of the urethra. This action provokes a lower tone of the smooth muscle fibers, which affects the relief of urinary excretion. At the same time, signs of compression and irritation that were caused by benign prostatic hyperplasia have disappeared.
It is noticed that the curative effect begins to manifest itself approximately 14 days after the first intake of Tamsulostad.
Pharmacokinetics
Tamsulostad for the minimum period of time and is fully absorbed in the digestive tract.
Absorption can be inhibited if there is a lot of food in the stomach. The kinetics of the drug is linear.
The maximum possible content of the active component in the serum is detected after six hours.
The connection with plasma proteins reaches 99%. The volume distribution is small - no more than 0.2 liters / kg.
For Tamsulostad, the effect of "first passage" is not characteristic. The drug component undergoes a slow metabolism in the liver, where active products are formed, which retain increased selectivity to alpha 1- adrenoreceptors. A larger amount of the drug component is in the blood stream in unchanged form.
Tamsulostad is excreted by the kidneys: 9% of the drug is excreted unchanged. The half-life with a single use of Tamsulostad is 10 hours.
Side effects of the tamsulostad
In some patients, treatment with Tamsulostad medication is accompanied by separate side effects:
- blurred vision, headache, dizziness;
- cardiopalmus;
- lowering of blood pressure;
- a runny nose, bleeding from the nose;
- dyspeptic manifestations, thirst;
- allergic manifestations;
- episodes of retrograde ejaculation;
- asthenic syndrome.
Dosing and administration
If the doctor does not prescribe otherwise, then one capsule of Tamsulostad is taken as standard each day. The best time for taking medication is in the morning, immediately after eating.
The capsule is swallowed in its entirety, washed down with 150-200 ml of water. Breaking and chewing capsule should not be.
The duration of the treatment course is determined by the attending doctor.
Overdose
Overdosage with medication Tamsulostad may be accompanied by a lowered blood pressure. If this happens, then it is necessary to take measures to facilitate the functioning of the cardiovascular system. The patient should lie down. In addition, you need to ensure the flow of fresh air.
In severe situations, infusion therapy is performed using vasoconstrictive drugs.
When taking a large amount of Tamsulostad, it is very important to observe the functioning of the kidneys and maintain all the vital functions of the body.
Hemodialysis in this case is not considered effective.
Often the patient is helped by cleansing the stomach and intestines, taking sorbent funds.
Interactions with other drugs
The combination of Tamsulostad and other alpha 1- adrenoblockers can lead to a drop in blood pressure.
Tamsulostad is used extremely cautiously in conjunction with inhibitors of CYP3A4.
Admission Tamsulostad in combination with paroxetine and ketoconazole may lead to an increase in the concentration limit values, which, however, has no clinical significance.
The speed of drug elimination can be increased by the action of Diclofenac and Warfarin.
There are no other important interactions between Tamsulostad and other medications.