Suppositories from HPV - human papillomavirus

Papillomavirus (namely, this genus is referred to as HPV) lives in the superficial skin tissues, gradually penetrating into the basal layer. It is a ubiquitous virus that penetrates into cellular structures, upsetting their natural processes. The method of transmission of papillomavirus is a sexual path, so this pathology is often treated by the doctors-venereologists. Usually treatment consists of a set of procedures that can include antiviral, immunomodulatory therapy, and even surgical intervention. In this article, we will consider one of the options for local treatment - a suppository or a suppository from HPV.

[1], [2], [3], [4], [5], [6], [7], [8],

Indications for use of suppositories from HPV

Scientists have identified and investigated more than a hundred types of human papillomavirus. For convenience, they were divided into several categories:

• papillomatous viruses without the risk of oncogeneity (these include 1, 2, 3 and 5 strains);
• viruses with a low risk of oncogeneity (6, 11, 42, 43 and 44 strain);
• viruses with a high risk of oncogenicity (16 and 18 strains, as well as some other types).

It becomes clear that the most dangerous are the strains of viruses 16 and 18. The risk is that under certain circumstances, these papillomaviruses potentiate pathological changes in the mucous and skin tissues, which can externally manifest itself in the growth of all kinds of warts, genital warts and papillomas, dysplasia, and also in development of oncological diseases.

Getting rid of HPV is extremely difficult. However, in order to avoid dangerous complications, it is necessary to be treated. The best result of treatment is the achievement of a stable period of remission, when the activity of the virus calms down, and the manifestations of the disease go to "no."

Names of suppositories from HPV 16 18

Viferon
Pharmacodynamics	Candles, which include human interferon (a specific factor in the fight against infection), vitamin C and α-tocopherol. Viferon differs antiviral, immunomodulating, and also inhibits the growth of pathological cells.
Pharmacokinetics	Reduction of the active ingredient level in the bloodstream is observed for 12 hours after rectal administration.
Use of suppositories against HPV during pregnancy	Use of suppositories after 14 weeks of bearing of a child is acceptable.
Contraindications for use	Propensity to allergy to the composition of suppositories.
Side effects	Rarely - dermatitis, burning, which pass independently for three days.
Method of application of suppositories from HPV	Most often, the following treatment regimen is used: 500,000 IU per 1 suppository twice a day (morning and night). The duration of therapy is up to 10 days.
Overdose	There is no description.
Interactions with other drugs	No adverse drug interactions were observed.
Storage conditions	Store in the dark and cool, you can - in the refrigerator.
Shelf life	Up to 2 years.

Genferon
Pharmacodynamics	The combined preparation in the form of suppositories with interferon alpha-2. It has antiviral, antimicrobial, immunomodulatory effects.
Pharmacokinetics	Duration of action with intravaginal and rectal administration - no more than 12 hours.
Use of suppositories against HPV during pregnancy	It is impossible to use Genferon in the first trimester of pregnancy. In extreme cases suppositories can be used in the period from II to III trimester.
Contraindications for use	Propensity to allergy.
Side effects	Allergies, fatigue, increased overall temperature, impaired appetite, pain in the muscles or joints, increased sweating.
Method of application of suppositories from HPV	Enter one suppository intravaginally or rectally, in the morning and at night (with an interval of not more than 12 hours). The duration of the therapeutic course is determined by the doctor: from 10 days to 3 months.
Overdose	There was no information on overdose.
Interactions with other drugs	No data.
Storage conditions	Keep in cool conditions.
Shelf life	Up to 2 years.

Panavir
Pharmacodynamics	Antiviral and immunomodulating suppository with plant extract. Panavir artificially increases the non-specific immune response and production of its own interferons.
Pharmacokinetics	Not studied.
Use of suppositories against HPV during pregnancy	It is undesirable.
Contraindications for use	Childhood, a tendency to allergic manifestations.
Side effects	Rarely - allergies.
Method of application of suppositories from HPV	Enter rectally 1 suppository every two days. After three injections, the time span is increased to three days. 5 candles are used for one course of therapy.
Overdose	No cases were observed.
Interactions with other drugs	No interactions found.
Storage conditions	Keep in the refrigerator.
Shelf life	Up to 3 years.

Galawit
Pharmacodynamics	Suppositories with the properties of immunomodulator and anti-inflammatory drug. The active substance changes the functional and metabolic capacity of macrophages, which reduces the activity of the inflammatory process and reduces intoxication.
Pharmacokinetics	There is no accumulation in the body. The therapeutic effect of the drug lasts three days after a single injection of a candle.
Use of suppositories against HPV during pregnancy	Contraindicated.
Contraindications for use	Propensity to allergy, pregnancy, breast feeding.
Side effects	Information was not received.
Method of application of suppositories from HPV	Standard therapeutic regimen: 1 suppository once a day for 10 days, rectally. After the tenth day, one suppository is used every other day. The total number of suppositories per course is 25 pieces.
Overdose	Not observed.
Interactions with other drugs	No interactions were observed.
Storage conditions	Keep at normal temperature.
Shelf life	Up to 2 years.

Laferobion
Pharmacodynamics	Suppositories with recombinant human interferon similar to a-2b. They have antiviral, anti-cancer and immunomodulating activity.
Pharmacokinetics	The limiting concentration of the drug increases in the interval between 4-10 hours after the administration of the candle.
Use of suppositories against HPV during pregnancy	Studies have not been conducted.
Contraindications for use	Pregnancy, a tendency to allergies, decompensation of the kidneys and liver.
Side effects	Flu-like condition, dry mucous, heart rhythm disturbances, thyroid dysfunction, dyspeptic phenomena, joint pain, insomnia, amenorrhea, runny nose, cough.
Method of application of suppositories from HPV	They use intrarectal, 1 suppository per day with a course of 5 days, after which they switch to the use of 1 suppository every other day. A course of therapy will require 20 candles.
Overdose	Information is absent.
Interactions with other drugs	It is expected to increase the effectiveness of antibiotics.
Storage conditions	Keep at normal temperature, away from children's access.
Shelf life	Up to 3 years.

Kipferon
Pharmacodynamics	Candles that combine the action of immunoglobulin and interferon. They show anti-chlamydial, antimicrobial, antiviral, anti-inflammatory and immunomodulatory effects.
Pharmacokinetics	Information is absent.
Use of suppositories against HPV during pregnancy	Contraindicated.
Contraindications for use	Pregnancy, breast feeding, allergic tendencies.
Side effects	Rarely - allergies.
Method of application of suppositories from HPV	Suppositories are suitable for both rectal and intravaginal use. Dosage - 1-2 suppositories per day. The duration of therapy is usually 10-12 days, but treatment can be continued according to the indications.
Overdose	Not observed.
Interactions with other drugs	No interactions.
Storage conditions	Keep in cool conditions.
Shelf life	Up to 12 months.

Betadine
Pharmacodynamics	Antimicrobial and antiseptic suppositories, the main component of which is iodine.
Pharmacokinetics	Has a fast local bactericidal effect. Iodine intake is insignificant.
Use of suppositories against HPV during pregnancy	It is allowed to apply with great care.
Contraindications for use	Thyroid dysfunction, treatment with radioactive iodine, children under 8 years old, a tendency to allergies.
Side effects	Allergic manifestations, local reactions in the form of burning, redness of the mucosa.
Method of application of suppositories from HPV	Enter 1 suppository up to 2 times a day. The duration of the therapeutic course is determined by the doctor.
Overdose	Signs of iodine intoxication: the taste of metal in the oral cavity, increased salivation, perspiration in the throat, puffiness of the eyes, indigestion, puffiness of the larynx and lungs.
Interactions with other drugs	It is not recommended to use simultaneously with alkaline and mercury preparations, with hydrogen peroxide and antiseptic agents.
Storage conditions	Keep at t ° to + 15 ° C.
Shelf life	Up to 5 years.

Candles that are prescribed for HPV can be applied rectally or intravaginally. The difference is that rectal application provides both local and systemic effects. With vaginal administration, the suppository only acts topically.

Which suppository from HPV is better, in each specific case the doctor decides. After all, there are suppositories with antiviral and bactericidal action, or with additional antifungal activity. In addition, the prescribed general treatment in the form of injections and oral medication is taken into account.