Sodium oxybutyrate

Sodium oxybutyrate has hypnotic, anesthetic, anxiolytic, and antihypoxic properties.

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Indications Sodium oxybutyrate

It is used to eliminate the following disorders:

• pathologies of the neurotic type;
• glaucoma;
• sleep problems;
• psychoses arising after surgical intervention;
• severe hypoxia.

Along with this, the drug is used in surgery - as a means of induction anesthesia during non-cavity type operations, while maintaining the spontaneous type of breathing process.

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Release form

It is released as a lyophilisate, which is well soluble in ethyl alcohol, as well as plain water. The powder is contained in ampoules of 5 or 10 ml. Inside the box there are 5 or 10 ampoules with powder.

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Pharmacodynamics

Sodium Oxybutyrate usually interacts with different endings, affecting the activity of various channels, including Ca2+ and K+ channels. As a result, the process of releasing activating conductors located inside presynaptic receptors is inhibited. This leads to postsynaptic slowing. The drug also has a suppressive effect on the NS.

In case of using small doses of the drug, an anxiolytic effect develops, the severity of neurotic disorders decreases, as well as individual vegetative manifestations in response to stress. The drug also has a hypnotic effect.

In high doses, the drug is used as a means of muscle relaxation and general anesthesia. At the same time, anticonvulsant, sedative and anti-shock effects develop. At the same time, elements of nootropic action can also be observed.

During therapy, the general resistance of the organism increases, as well as the heart with the brain and other organs in relation to oxygen deficiency. Improvement of microcirculation processes, increased glomerular filtration activity and stabilization of renal activity in case of blood loss are also observed.

It was found that the drug is able to pass through histohematic barriers.

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Dosing and administration

The drug can be used orally, as well as for intramuscular and intravenous injections.

If general anesthesia is required, the solution should be injected into the vein very slowly - a maximum of 1-2 ml/minute. If anesthesia needs to be maintained, the drug is administered additionally - at a dose of 40 mg/kg. For induction anesthesia, children are prescribed 100 mg/kg (a glucose solution is added to the drug, drop by drop) for 5-10 minutes.

When administering the drug intramuscularly, the dose is 120-150 mg/kg.

Adults need to take 100-200 mg/kg of the drug orally, and children – no more than 150 mg/kg.

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Use Sodium oxybutyrate during pregnancy

It is prohibited to use Sodium oxybutyrate during pregnancy (the only exception is obstetric procedures).

The medicine should not be used during lactation because it has a sedative effect on the baby.

Contraindications

Main contraindications:

• hypokalemia;
• severe forms of toxicosis in pregnant women, against the background of which there is a syndrome of increased pressure and hypokalemia;
• myasthenia.

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Side effects Sodium oxybutyrate

It has been found that in the case of rapid intravenous injection of the solution, the appearance of individual side effects is possible: respiratory dysfunction, a feeling of psychomotor agitation, vomiting, a feeling of drowsiness, severe nausea, and also hypokalemia.

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Overdose

As a result of poisoning with the drug, a feeling of excitement, twitching of the limbs may occur, and sometimes respiratory arrest may also be observed.

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Interactions with other drugs

When sodium oxybutyrate is combined with anesthetic and analgesic drugs, the properties of these drugs are often significantly enhanced.

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Storage conditions

Sodium oxybutyrate is stored in a dark place, inaccessible to children. Temperature values are within 15-25°C.

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Special instructions

Reviews

Sodium oxybutyrate is often discussed on various forums dedicated to medicine. However, reviews of it often have little to do with its medical effects - patients usually use it for completely different purposes.

For example, some users report using the drug as a substitute for an alcoholic drink. It is important to understand that this substance causes very rapid addiction, which leads to complications that are more powerful in their negative impact than the result of alcohol addiction.

At the same time, patients ask many questions related to the specifics of using the drug - about using this product independently at home, about the place of purchase, and also about the dosage sizes for treating various disorders.

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Shelf life

Sodium oxybutyrate is allowed to be used for 4.5 years from the date of release of the drug.

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