Sodium aminosalicylate

Sodium aminosalicylate is a drug with anti-tuberculosis action.

[1], [2], [3], [4], [5], [6],

Indications of the sodium aminosalicylate

It is used to eliminate tuberculosis, when it is not possible to use other drugs with a stronger effect.

[7], [8]

Release form

The release occurs in pellets, which are packaged in packages of 4 g (in the package 1 or 100 bags) or 100 g (inside the box - 1 such package).

[9], [10], [11]

Pharmacodynamics

The drug has bacteriostatic properties, acting exclusively on the bacterium Mycobacterium tuberculosis. It should be noted that in comparison with other antituberculosis drugs this drug has a less pronounced effect. If it is used as a monotherapeutic agent, resistance to aminosalicylic acid develops rather quickly.

[12], [13], [14]

Pharmacokinetics

After use, the medicine is quickly absorbed, getting inside the blood serum, as well as the tissues of the body.

Metabolism mainly occurs in the liver, beginning after the 0.5-1 hour after taking the medication. Inside the liver, the process of acetylation of the substance is carried out, followed by its connection with glycine.

About 90-100% of the portion consumed is excreted per day with urine.

[15], [16], [17], [18], [19], [20]

Dosing and administration

You need to take the medicine 0.5-1 hour after eating, drinking it with mineral water or milk.

For children weighing between 10-40 kg, doses are prescribed at a rate of 200 mg / kg per day. This portion should be divided into 3-4 uses.

For children weighing more than 40 kg, as well as adults, the dosage is 5 grams of medication taken twice per day.

If the patient has a poor tolerability of drugs, it is necessary to reduce dosage.

The length of the course depends on how the disease progresses, and on the degree of its severity. Usually it lasts a minimum of 3-5 months. If necessary, it is allowed to prolong treatment.

[25], [26], [27], [28]

Use of the sodium aminosalicylate during pregnancy

There is information that when taking aminosalicylates in the 1 st trimester, it is possible that the fetus develops congenital anomalies. Therefore, the use of the drug during pregnancy is prohibited.

Small amounts of aminosalicylic acid are excreted with the mother's milk, which is why it is required to refuse breastfeeding for the period of therapy.

Contraindications

The main contraindications:

• liver / kidney failure;
• hepatic cirrhosis or hepatitis;
• amyloidosis in the field of internal organs;
• an ulcer in the gastrointestinal tract;
• hypothyroidism;
• seizures of epilepsy;
• hypersensitivity to aminosalicylic acid, as well as its salts.

[21], [22]

Side effects of the sodium aminosalicylate

Taking medication can cause some side effects:

• sometimes: vomiting with diarrhea and nausea, as well as hypokalemia;
• Occasionally: skin lesions, arthralgia, fever, mononucleosis-like infectious-type syndrome, encephalitis with lymphadenopathy and jaundice. In addition, hepatosplenomegaly, kidney failure, leuko- and thrombocytopenia, as well as agranulocytosis, hemolytic form of anemia (in people with deficiency of G6PD element), and eosinophilia;
• single: there are psychoses;
• in the case of long reception of large portions of drugs: develops goitre or hypothyroidism.

[23], [24]

Overdose

Manifestations of intoxication: vomiting with nausea, as well as diarrhea. Perhaps the development of psychosis or increased severity of side effects.

Based on the severity of symptoms of overdose, as well as their nature, it is necessary either temporarily or permanently stop taking drugs. To remove the violations, you will need the use of calcium chloride, antihistamines, vitamin C. If signs of allergies continue to occur for a long time, you should use corticosteroids.

[29], [30]

Interactions with other drugs

Aminosalicylic acid prolongs the half-life of isoniazid.

Negative manifestations of salicylates with aminosalicylates have an additive character.

Probenecid is able to potentiate the toxic properties of aminosalicylate - it disrupts the process of its excretion through the kidneys and increases its plasma values.

[31], [32], [33], [34]

Storage conditions

Sodium aminosalicylate must be kept in a place inaccessible to young children. The temperature level is a maximum of 25 ° C.

[35], [36]

Shelf life

Sodium aminosalicylate can be used in the period of 2 years since the release of the drug.

[37]