Sodium aminosalicylate

Sodium aminosalicylate is a drug with anti-tuberculosis action.

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Indications Aminosalicylate sodium

It is used to eliminate tuberculosis when it is not possible to use other drugs with a stronger effect.

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Release form

The product is produced in granules, which are packaged in 4 g bags (1 or 100 bags per package) or 100 g bags (there is 1 such bag inside the box).

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Pharmacodynamics

The drug has bacteriostatic properties, affecting only the Mycobacterium tuberculosis bacterium. It should be taken into account that, compared to other anti-tuberculosis drugs, this drug has a less pronounced effect. If it is used as a monotherapeutic agent, resistance to aminosalicylic acid develops quite quickly.

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Pharmacokinetics

After use, the drug is quickly absorbed, entering the blood serum and body tissues.

Metabolism occurs mainly in the liver, beginning 0.5-1 hour after taking the drug. The process of acetylation of the substance with its subsequent connection with glycine occurs inside the liver.

About 90-100% of the consumed dose of the drug is excreted in urine per day.

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Dosing and administration

The medicine should be taken 0.5-1 hour after eating, washing it down with mineral water or milk.

For children weighing between 10-40 kg, the dose is 200 mg/kg per day. This portion should be divided into 3-4 doses.

For children weighing more than 40 kg, as well as adults, the dosage is 5 g of the medicine taken twice a day.

If the patient has poor tolerance to the drug, the dosage must be reduced.

The duration of the course depends on how the disease progresses and its severity. Usually it lasts at least 3-5 months. If necessary, it is allowed to extend the treatment.

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Use Aminosalicylate sodium during pregnancy

There is information that when taking aminosalicylates in the 1st trimester, the fetus may develop congenital anomalies. Therefore, the use of the drug during pregnancy is prohibited.

Small amounts of aminosalicylic acid are excreted in breast milk, which requires that breastfeeding be discontinued during therapy.

Contraindications

Main contraindications:

• liver/kidney failure;
• liver cirrhosis or hepatitis;
• amyloidosis in the area of internal organs;
• ulcer in the gastrointestinal tract;
• hypothyroidism;
• epileptic seizures;
• hypersensitivity to aminosalicylic acid and its salts.

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Side effects Aminosalicylate sodium

Taking the medication can cause some side effects:

• sometimes: vomiting with diarrhea and nausea, as well as hypokalemia;
• rarely: skin lesions, arthralgia, feverish state, infectious mononucleosis-like syndrome, encephalitis with lymphadenopathy and jaundice. In addition, hepatosplenomegaly, renal failure, leukopenia and thrombocytopenia, as well as agranulocytosis, hemolytic anemia (in people with a deficiency of the element G6PD) and eosinophilia;
• isolated: psychoses are observed;
• in case of prolonged use of large doses of drugs: goiter or hypothyroidism develops.

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Overdose

Manifestations of intoxication: vomiting with nausea, as well as diarrhea. Development of psychosis or increased severity of side effects is possible.

Based on the severity of overdose symptoms and their nature, it is necessary to either temporarily or permanently stop taking the drug. To eliminate the disorders, it will be necessary to use calcium chloride, antihistamines, and vitamin C. If the signs of allergy continue to appear for a long time, corticosteroids should be used.

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Interactions with other drugs

Aminosalicylic acid increases the half-life of isoniazid.

The adverse effects of salicylates and aminosalicylates are additive.

Probenecid can potentiate the toxic properties of aminosalicylate – it disrupts the process of its excretion through the kidneys and increases its plasma levels.

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Storage conditions

Sodium aminosalicylate should be kept out of the reach of small children. Temperature level – maximum 25°C.

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Shelf life

Sodium aminosalicylate can be used for a period of 2 years from the date of release of the drug.

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