Senadexin

Senadeksin has a laxative effect.

Indications Senadexina

It is used for the following disorders:

• constipation caused by poor peristalsis and hypotension of the colon;
• helps to stabilize stool in such disorders as hemorrhoids with proctitis and anal fissures;
• constipation of a spastic or atonic nature (regardless of origin).

[ 1 ]

Release form

The medicine is released in tablets, in the amount of 10 pieces inside a blister pack. The box contains 1 or 2 such packages.

[ 2 ]

Pharmacodynamics

The medicine is made from plant materials and has laxative properties, affecting the peristaltic activity of the colon.

The medicinal effect is provided by anthra- and other glycosides, transiting after taking the capsule inside through the stomach with the small intestine, without being absorbed. Inside the colon, anthraglycosides are subject to breakdown under the influence of intestinal microflora, transforming into active derivatives - anthrones and anthranols, which irritate the interoreceptors of the colon, thereby stimulating its peristalsis and accelerating the process of removing intestinal contents.

Senadeksin prevents the absorption of water with electrolytes. The osmotic effect allows to increase the volume of feces, as well as the force of filling pressure, due to which the stimulation of peristalsis is improved.

The effect of the drug develops after 6-11 hours. If the drug is used for a long time, the intensity of the medicinal effect may decrease (due to a decrease in potassium levels in the blood).

Pharmacokinetics

The metabolites of anthraglycosides contained in senna are practically not absorbed. Their excretion occurs mainly with feces, and a smaller part of the substance is excreted with urine. In addition, the drug is excreted with sweat, and can also (in small quantities) pass into breast milk.

Dosing and administration

The medication should be taken orally, in the morning or evening, with plain water.

For adolescents (aged 12 years and over), the medicine is prescribed in a dose of 2 tablets once or twice a day. The maximum permissible daily dose is 4 tablets.

Elderly people should begin treatment by taking 1 tablet per day.

Use Senadexina during pregnancy

Senadeksin is prohibited during lactation or pregnancy.

Contraindications

Main contraindications:

• nausea with vomiting, as well as inflammation in the gastrointestinal tract, which has an acute form (such as regional enteritis and colitis);
• presence of allergies to drug components;
• intestinal obstruction, spastic constipation, strangulated hernia, cystitis and bleeding in the gastrointestinal tract or uterus;
• undiagnosed diseases in the digestive system that developed in connection with acute intestinal disorders or surgical operations (appendicitis with peritonitis, as well as diarrhea and diverticulitis);
• pain in the epigastrium of unknown origin;
• severe water-electrolyte imbalance disorders;
• liver dysfunctions of organic origin;
• pain of a spastic nature;
• rectal hemorrhages.

Side effects Senadexina

Side effects are reversible and quickly disappear when the drug is stopped or its dosage is reduced. Among the reactions:

• digestive disorders: diarrhea, anorexia, vomiting, bloating, abdominal pain, colic, nausea, intestinal pseudomelanosis, as well as intestinal atony, digestive disorders and weight loss;
• problems with the urogenital system: hematuria or proteinuria, as well as changes in the color of urine;
• metabolic disorders: loss of electrolytes, which can lead to problems with the heart, muscle weakness, cramps, fatigue and collapse;
• immune lesions: urticaria, rashes, local or generalized exanthema, and itching.

Overdose

Symptoms of poisoning: the appearance of intestinal colic, cramps, nausea, pain in the epigastric region, and diarrhea. Along with this, vascular collapse, electrolyte imbalance or intestinal function disorder, and in addition, a metabolic form of acidosis develop.

To eliminate the disorders, it is necessary to perform gastric lavage and symptomatic procedures. If necessary, rehydration is performed (to replenish the volume of lost fluid).

Interactions with other drugs

Combination with quinidine sulfate may cause a decrease in the level of active elements in the blood.

The combination of the drug with SG may lead to the development of cardiac arrhythmia (due to the occurrence of hypokalemia).

Concomitant use with antiarrhythmic drugs, diuretics and corticosteroids may provoke the development of muscle weakness.

Long-term use of Senadexin or its administration in large doses negatively affects the absorption of tetracyclines.

The drug weakens the therapeutic effect of drugs that are slowly absorbed.

[ 3 ], [ 4 ]

Storage conditions

Senadeksin should be kept out of the reach of small children. Temperature – within 25°C.

[ 5 ]

Shelf life

Senadeksin can be used for 3 years from the date of manufacture of the therapeutic agent.

Application for children

The drug should not be prescribed to children under 12 years of age.

[ 6 ]

Analogues

The analogs of the drug are Xena, Slabilen, Fibralax with Senadex, Senade and licorice syrup, RectActive, glycerin suppositories, Lactulose with Guttalax, and in addition, Norgalax with Duphalac and Laxatin with Bisacodyl.

Reviews

Senadeksin receives a large number of positive reviews regarding its high medicinal effectiveness.

The most common disadvantages include the drug's addictive nature and a fairly large number of possible side effects.