Senadé

Senadé is a medical preparation of plant origin, which stimulates intestinal motility and thus has a laxative effect.

Indications of the senadé

Pathological conditions requiring the use of Senada:

• stool retardation is chronic;
• reduced or absent intestinal peristalsis;
• correction of the stool with such pathologies as: hemorrhoids, inflammation of the intestinal mucosa, anal channel cracks;
• before diagnostic and therapeutic procedures, for cleaning the intestines.

[1]

Release form

The drug goes on sale in the form of tablets of a round form of coffee or dark chocolate color with inclusions. On one side of the tablets there is a line for division, on the second - the inscription "CIPLA". They are packaged in twenty pieces on plates. In total there are 500 tablets in the box.

[2]

Pharmacodynamics

As a result of pressure on the nerve endings of the thick part of the intestine, there is a reflex increase in peristalsis and a laxative effect occurs. The products that form sennosides with the complicity of the enzymes of the usual intestinal flora have an effect on the mucous membrane. Also Senadé, due to the containment of the adsorption of Na, H2O, and D-xylose ions, increases the content and increases the motility of the large intestine. This is explained by the increase in the density of prostaglandin E2 in the walls of the intestine, due to activation of the release of Na and H2O.

[3], [4], [5],

Pharmacokinetics

The active substance of Senade is practically not absorbed. The excretion occurs mainly along with feces or slightly with urine. Bioavailability of the system is about 5%. Laxative effect occurs after eight to ten hours after taking the medication. In the thick part of the intestine a reaction occurs, as a result of which active free anthraquinones are formed.

[6], [7], [8],

Dosing and administration

Since the medicine has a ruminant effect, it is most often used in the evening before going to bed once a day.

Adult population and children over the age of twelve:

It is recommended that you take one pill at bedtime, while drinking water or any other liquid. Maximum allowed to take three tablets.

Children from six to twelve years of age:

Before bed, you can use the floor of the pill, squeezed it with water. Ultimately, you can take two tablets a day.

To select an effective dose for a patient, you need to gradually increase it on the floor of the pill for three days. If you do not reach the maximum dose of the drug, you should contact the doctor.

Use of the senadé during pregnancy

The use of the drug in the gestational period is possible only under the supervision of medical personnel, since the use of medication in this period is prohibited. Information about the studies does not contain data on the possible teratogenic effects of the drug. As a result of taking Senade on time gestation may increase the likelihood of undesirable effects.

Due to the fact that Senadé enters the mother's milk, breastfeeding should be stopped. A child with a mother taking medication and breastfeeding can get a loose stool. But if you keep the recommended dosage, this may not happen.

Contraindications

Senada can not be used in the case of such pathologies:

• Increased sensitivity to the components of the drug;
• Uterine bleeding;
• Acute inflammatory processes in the intestine;
• Pregnancy;
• Gastrointestinal bleeding;
• Stomach ulcers;
• Inflammation of the bladder;
• Lactation;
• Children up to six years.

[9], [10]

Side effects of the senadé

The patient who uses Senada should be aware of the likely side effects:

• bloating;
• diarrhea;
• nausea and vomiting;
• allergic reactions;
• convulsions;
• presence of blood and protein in the analysis of urine;
• melanosis of intestines.

[11]

Overdose

If the patient takes a dosage of the drug that is significantly higher than the recommended one, the next dangerous sign of an overdose may appear - severe diarrhea, which leads to dehydration.

To treat this condition, the patient needs to drink as much fluid as possible. Due to this, the compensation effect will occur, and the lost liquid will recover. In some cases, when this therapy has no effect, intravenous administration of plasma substitutes may be required.

[12], [13], [14],

Interactions with other drugs

The active substance of Senade is practically not absorbed. The excretion occurs mainly along with feces or slightly with urine. Bioavailability of the system is about 5%. Laxative effect occurs after eight to ten hours after taking the medication. In the thick part of the intestine a reaction occurs, as a result of which active free anthraquinones are formed.

Use during pregnancy

The use of the drug in the gestational period is possible only under the supervision of medical personnel, since the use of medication in this period is prohibited. Information about the studies does not contain data on the possible teratogenic effects of the drug. As a result of taking Senade on time gestation may increase the likelihood of undesirable effects.

Due to the fact that Senadé enters the mother's milk, breastfeeding should be stopped. A child with a mother taking medication and breastfeeding can get a loose stool. But if you keep the recommended dosage, this may not happen.

[15], [16], [17], [18],

Storage conditions

The temperature regime for the storage of tablets should be observed at 25 ° C. The storage place must be dry and inaccessible to children.

[19]

Special instructions

Reviews

The medication acts gently. The action basically comes in eight hours, although there are people who have the effect of receiving observed after a couple of hours. If, after eating Senadé, the patient complains of increasing diarrhea, severe dehydration and abdominal pain - you should immediately contact a doctor. A significant disadvantage with the use of this drug, is the rapid addiction, because of this, the intestine can practically cease to function itself.

In the information space there are recommendations on the use of this medication for weight reduction. For this, it should be taken half an hour before meals. But to apply it in this capacity (because of addiction) costs no more than two weeks.

Shelf life

If all the requirements for the storage of a medicine are met, it can be stored for up to three years.