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Remavir
Last reviewed: 03.07.2025
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Remavir is an antiviral medication with the active ingredient rimantadine (a derivative of the component adamantane).
The drug has an effective effect against viruses that cause tick-borne encephalitis, herpes subtypes 1 or 2, and also against viral strains of influenza subtype A.
The medicinal substance has been found to have antitoxic and immunomodulatory activity.
The polymer structure of the drug promotes long-term circulation of the active element within the human body, which means it can be used not only for therapy, but also for prevention.
Indications Remavira
It is used to treat influenza subtype A (as a prophylactic drug for children and adults, and also for early therapy for adults).
Release form
The element is released in tablets - 10 pieces inside a cell plate. There are 2 plates in a box.
Pharmacodynamics
The active element of the drug inhibits viral activity even in the early phase of specific reproduction (in the interval between the passage of the virus into cells and the initial stage of RNA transcription).
Remantadine increases the functional activity of natural killer NK cells – B-, as well as T-lymphocytes; in addition, it stimulates the production of interferon-α and γ. The active element acts as a weak base and increases the values of endosomal pH (endosomes have a vacuole wall and surround viral elements when passing into cells).
Prevention of acidification within the designated vacuoles results in blocking the process of synthesis of the viral envelope with the endosomal wall. Due to this, the movement of viral genetic material into the cellular cytoplasm is prevented.
The drug stops the transcription of the viral genome, suppressing the removal of virus particles from cells.
The use of a daily prophylactic dose (0.2 g) of the medication reduces the likelihood of developing influenza and weakens the intensity of its manifestations and serological response.
The medicinal effect is observed in the case of using rementadine during the first 18 hours from the moment of the first symptoms of the pathology.
Pharmacokinetics
Suction.
When administered orally, the medication is almost completely absorbed in the intestine, providing high bioavailability values.
Distribution processes.
After a single administration of a 0.1 g portion, the average plasma Cmax values are 74 ng/ml (within 45-138 ng/ml). In healthy adults (20-44 years of age), these values are noted after 5-7 hours.
About 40% of the drug is synthesized with blood intraplasmic protein (mostly with albumins). The half-life of the 1st dose in the age group of 20-44 years is on average 25 hours, and in people aged 71-79 years the average values are 32 hours.
Exchange processes.
Remavir undergoes extensive intrahepatic metabolism via conjugation, hydroxylation, and glucuronidation.
Withdrawal.
The presence of 3-hydroxylated metabolic elements is noted in the blood plasma. Together with other metabolites, they equal 74±10% of the 1st portion of 0.2 g. Excretion of metabolic elements with urine occurs over 72 hours. Less than 25% of the drug is excreted unchanged with urine.
Kidney failure.
In people with this disorder, plasma values of the metabolic components of the drug increase. The dose of rimantadine should be reduced by 50% with CC values in the range of 5-29 ml per minute.
Dosing and administration
Remavir should be taken after meals, washing down the tablets with plain water.
To prevent flu: take 0.1 g of the substance twice a day. For children, the dose is selected based on 5 mg/kg, and it should be taken once a day. A child can take a maximum of 0.15 g of the medicine per day.
For flu therapy: the cycle lasts 5-7 days, the drug should be taken daily - 0.1 g 2 times a day (after the first symptoms of the disease). If there is a severe disruption in the liver or kidneys, the medicine in a dose of 0.1 g is taken 1 time per day.
Treatment for influenza subtype A should begin within the first 24-48 hours from the onset of early symptoms of the disease; the entire cycle often lasts 5-7 days.
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Use Remavira during pregnancy
It is prohibited to use Remavir during breastfeeding or pregnancy.
Contraindications
Contraindicated for use by individuals with severe hypersensitivity to rimantadine.
Caution is required when administering to people with severe liver or kidney dysfunction, as well as to epileptics.
Overdose
Symptomatic measures are taken in case of intoxication. Hemodialysis procedures do not produce results.
Storage conditions
Remavir should be stored in a dark, dry place, out of reach of children. The temperature level should not exceed 25°C.
Shelf life
Remavir is allowed to be used for a period of 24 months from the date of manufacture of the drug.
Application for children
Not prescribed to infants under 12 months of age.
Analogues
The analogues of the drug are the drugs Rimantadine and Remantadine.
Reviews
Remavir receives good reviews - if the drug is used as quickly as possible after contact with an infected person, it demonstrates a high antiviral effect.
Attention!
To simplify the perception of information, this instruction for use of the drug "Remavir" translated and presented in a special form on the basis of the official instructions for medical use of the drug. Before use read the annotation that came directly to medicines.
Description provided for informational purposes and is not a guide to self-healing. The need for this drug, the purpose of the treatment regimen, methods and dose of the drug is determined solely by the attending physician. Self-medication is dangerous for your health.