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Remavir
Last reviewed: 23.04.2024
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Remavir is an antiviral drug with the active element rimantadine (component derivative adamantane).
The drug has an effective effect on viruses that cause the development of tick-borne encephalitis, herpes simplex subtypes 1 or 2, and at the same time relatively viral strains of influenza subtype A.
The drug has antitoxic and immunomodulating activity.
The polymer structure of the drug contributes to the long-term circulation of the active element inside the human body, so that it can be used not only for therapy, but also for prevention.
Indications Removing
It is used for the treatment of influenza subtype A (as a prophylactic drug for children and adults, and in addition to early therapy for adults).
Release form
The release of the element is implemented in tablets - 10 pieces inside the cell plate. In the box - 2 records.
Pharmacodynamics
The active element of drugs inhibits viral activity even in the early phase of specific reproduction (between the passage of the virus into the cells and the initial stage of RNA transcription).
Remantadin increases the functional activity of natural killer cells of NK-cells - B-, as well as T-lymphocytes; in addition, it stimulates the production of interferon-α and γ. The acting element acts as a weak base and increases the endosomal pH values (endosomes have a vacuole wall and surround viral elements as they pass inside the cells).
Prevention of acidification within the indicated vacuoles leads to blocking of the process of synthesis of the viral envelope with the endosomal wall. This prevents the transfer of viral genetic material into the cellular cytoplasm.
The drug stops the transcription of the viral genome, suppressing the removal of virus particles from the cells.
The use of a daily prophylactic dose (0.2 g) of the drug reduces the likelihood of developing influenza and weakens the intensity of its manifestations and serological response.
The drug effect is observed in the case of rementadine use during the first 18 hours after the onset of the first symptoms of pathology.
Pharmacokinetics
Suction.
When administered orally, the drug is almost completely absorbed inside the intestine, ensuring high bioavailability values.
Distribution processes.
After a single injection of a dose of 0.1 g, the average plasma Cmax is 74 ng / ml (within 45-138 ng / ml). In adults, healthy people (age 20-44 years), these values are observed after 5-7 hours.
About 40% of the drug is synthesized with blood plasma protein (most - with albumin). The term half-life of the 1st portion in the age group of 20–44 years is on average 25 hours, and in people aged 71–79 years, the average values are 32 hours.
Exchange processes.
Remavir undergoes intensive intrahepatic exchange by conjugation, hydroxylation, and glucuronization.
Inference.
Inside the blood plasma there are 3 hydroxylated metabolic elements. Together with other metabolites, they are equal to 74 ± 10% of the first portion of 0.2 g. Excretion of metabolic elements along with urine is performed for 72 hours. With the urine in an unchanged state, less than 25% of the drug is excreted.
Kidney failure.
People with this disorder increase the plasma values of the metabolic components of the drug. A portion of rimantadine should be reduced by 50% with a CC in the range of 5-29 ml per minute.
Dosing and administration
It is required to consume Remavir after taking a meal, washing down the taken tablets with plain water.
To prevent flu: use 0.1 g of the substance 2 times a day. Children need a serving of 5 mg / kg, and it should be taken 1 time per day. During the day, a child can use a maximum of 0.15 g of the drug.
For therapy of influenza: the cycle lasts 5-7 days, the drug is required to be taken daily - 0.1 g 2 times a day (after the onset of the first symptoms of the disease). If there is a severe disorder in the liver or kidneys, the medication in a 0.1 g serving is consumed 1 time per day.
It is necessary to begin treatment for influenza A subtype within the first 24-48 hours from the time of the development of the early manifestations of the disease; The whole cycle often consists of 5-7 days.
[12]
Use Removing during pregnancy
It is forbidden to use Remavir during HS or pregnancy.
Contraindications
It is contraindicated to use to persons with strong sensitivity concerning rimantadine.
Caution is required when administered to people with severe disorders of the liver or kidneys, as well as epileptics.
Side effects Removing
Among the side effects are:
- lesions of the digestive system: nausea, anorexia, gastralgia, and in addition, vomiting and dryness of oral mucous membranes;
- dysfunction of the central nervous system: insomnia, severe fatigue, concentration disorder, nervousness, dizziness and headaches.
Overdose
With intoxication, symptomatic measures are taken. Hemodialysis procedures have no effect.
Storage conditions
Remavir is required to keep in a closed from the children, dark and dry place. The temperature level is not more than 25 ° C.
Shelf life
Remavir is allowed to use for a 24-month term from the time of manufacture of the drug.
Application for children
Do not assign to infants up to 12 months of age.
Analogs
Analogues of drugs are drugs Rimantadine with rimantadine.
Reviews
Remavir receives good reviews - in the case of using drugs as quickly as possible after contact with an infected person, it demonstrates a high antiviral effect.
Attention!
To simplify the perception of information, this instruction for use of the drug "Remavir" translated and presented in a special form on the basis of the official instructions for medical use of the drug. Before use read the annotation that came directly to medicines.
Description provided for informational purposes and is not a guide to self-healing. The need for this drug, the purpose of the treatment regimen, methods and dose of the drug is determined solely by the attending physician. Self-medication is dangerous for your health.