Remicade

Remisid is a drug from the NSAID group of substances; it is a selective inhibitor of COX-2 activity.

The anti-inflammatory effect of the nimesulide component when administered in equimolar amounts at the initial stage of inflammation development can be compared with the action of piroxicam and indomethacin. By slowing down the binding of PG in the inflammation zone, the drug has almost no effect on the processes of synthesis of regulatory PG inside the kidneys and stomach walls.

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Indications Remicida

It is used for local therapy in cases of musculoskeletal disorders, which are accompanied by inflammation, pain and stiffness of movement. Such diseases include periarthritis, tendosynovitis, osteoarthritis with post-traumatic tendinitis, and muscle strains. It is also prescribed for high-intensity physical activity in relation to joints.

Release form

The component is released in the form of a gel, inside a tube with a capacity of 30 g; in a box - 1 tube.

Pharmacodynamics

The drug inhibits the activity of platelet-activating factor, histamine, tumor necrosis factor α, proteinases, and along with this, the formation of free radicals associated with oxygen.

After external treatment, it leads to a reduction or elimination of pain in the area of application (including pain affecting the joints - both during movement and at rest), reduces joint swelling and stiffness in the morning, and increases the range of motion of the joints.

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Dosing and administration

The gel must be used externally. Before the treatment, the epidermis area must be washed and wiped dry. A 3 cm gel strip is required for treatment. It is applied in a thin layer to the affected areas, rubbing in a little. 3-4 such procedures should be performed per day.

The duration of such a course is selected individually, taking into account the result of the treatment. The maximum duration is 1 month.

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Use Remicida during pregnancy

It is prohibited to use Remisid during breastfeeding or pregnancy.

Contraindications

Main contraindications:

• severe intolerance associated with nimesulide and other components of the drug;
• infections affecting the skin and dermatitis;
• skin damage;
• use in people who suffer from allergies (expressed in the form of urticaria, bronchial spasms and runny nose) in relation to aspirin or other medications that slow down the activity of PG binding.

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Side effects Remicida

The use of the gel may lead to local irritation of the epidermis (moderate or mild intensity): peeling, signs of allergy, erythema, itching and rashes. Rarely, people with intolerance have developed anaphylactic symptoms - suffocation, vasomotor rhinitis, Quincke's edema and bronchial spasm.

Overdose

The use of Remisid on a large area of the epidermis or exceeding the required dosage may lead to the appearance of general negative symptoms characteristic of nimesulide and other NSAIDs: headaches, dyspepsia and pain affecting the epigastric region.

It is necessary to reduce the dosage or stop the drug, and also perform symptomatic procedures.

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Interactions with other drugs

External treatment with the gel does not lead to the development of interaction with other medications. But it is necessary to take into account that in case of possible passage into the circulatory system, nimesulide is capable of potentiating the toxic properties and effectiveness of many drugs - by displacing them from the synthesis sites with intraplasmic protein with a subsequent increase in the volume of their free fraction in the blood. Therefore, Remisid is very carefully used in combination with phenytoin, cyclosporine, anticoagulants, hypotensive drugs and digoxin, as well as with diuretics, lithium substances, methotrexate, other NSAIDs and antidiabetic drugs for oral administration.

After combined local use of several NSAIDs, local irritation (redness or peeling of the skin and urticaria) may occur.

Antirheumatic drugs (aminoquinolones and gold drugs) and GCS potentiate the anti-inflammatory activity of Remisid.

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Storage conditions

Remisid should be stored in a place out of reach of children. Temperature indicators – up to 25°C. Do not freeze the gel.

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Shelf life

Remisid is allowed to be used within a 24-month period from the date of production of the substance.

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Application for children

Not prescribed in pediatrics.

Analogues

Analogues of the drug are Nimedar and Frenag gel.

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