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Remisid is a drug from the NSAID group of substances; it is a selective inhibitor of COX-2 activity.

The anti-inflammatory effect of the component nimesulide with the introduction of equimolar indicators at the initial stage of development of inflammation can be compared with the effect of piroxicam and indomethacin. By slowing the binding of PG in the area of inflammation, the medication of mail does not affect the synthesis of regulatory PG inside the kidneys, as well as the gastric walls.

[1]

Indications Reason

It is used for local therapy in cases of ODA lesions, against which inflammation, pain and stiffness of movements are noted. Among such diseases are periarthritis, tendosynovitis, osteoarthritis with tendonitis of post-traumatic nature, as well as muscle sprains. Also prescribed for those with a high intensity of physical activity in relation to the joints.

Release form

The release of the component is realized in the form of a gel, inside a tube with a capacity of 30 g; in the box - 1 tube.

Pharmacodynamics

The drug inhibits the activity of the platelet activating factor, histamine, the α-factor of tumor necrosis, proteinases, and with it the formation of free radicals associated with oxygen.

After external treatment leads to a weakening or elimination of pain in the area of application (among those, pain affecting the joints, both during movement and at rest), reduces joint swelling and stiffness in the morning, and also increases the motor volume of the joints.

[2], [3], [4],

Dosing and administration

Use the gel must be externally. Before the treatment procedure, the area of the epidermis needs to be washed and wiped dry. For processing, a gel strip of 3 cm is required. It is applied with a thin layer on the affected areas, rubbing a little. 3-4 procedures should be performed per day.

The duration of this course is chosen individually, taking into account the result of the treatment. The maximum duration is 1 month.

[6], [7], [8]

Use Reason during pregnancy

It is forbidden to use Remisid when breastfeeding or pregnancy.

Contraindications

The main contraindications:

• severe intolerance associated with nimesulide and other elements of the drug;
• skin infections and dermatitis;
• skin damage;
• use in people who suffer from allergies (expressed in the form of urticaria, bronchial spasms and rhinitis) against aspirin or other drugs that slow down the activity of PG binding.

[5],

Side effects Reason

The use of the gel can lead to local irritation of the epidermis (moderate or mild degree of intensity): desquamation, signs of allergy, erythema, itching and rash. Occasionally, people with intolerance had anaphylactic symptoms — asphyxiation, vasomotor rhinitis, angioedema, and bronchial spasm.

Overdose

Using Remisid on a large area of the epidermis or exceeding the required dosage can lead to the appearance of common negative symptoms characteristic of nimesulide and other NSAIDs: headaches, dyspepsia and pain affecting the epigastric zone.

It is required to reduce the dosage or cancel the medication, as well as perform symptomatic procedures.

[9], [10]

Interactions with other drugs

External treatment with gel does not lead to the development of interaction with other medicines. But it is necessary to take into account that in case of possible passage into the circulatory system, nimesulide is able to potentiate the toxic properties and effectiveness of many drugs - by displacing from the sites of synthesis with intraplasma protein with a subsequent increase in the volume of their free fraction inside the blood. Therefore, Remisid is very carefully used in combination with phenytoin, cyclosporine, anticoagulants, hypotensive drugs and digoxin, and in addition with diuretic, lithium substances, methotrexate, other NSAIDs and antidiabetic drugs for oral administration.

After the combined local use of several NSAIDs, local irritation may occur (reddening or peeling of the skin and urticaria).

Antirheumatic drugs (aminoquinolones and gold drugs) and GCS potentiate the anti-inflammatory activity of Remisid.

[11], [12]

Storage conditions

Remisid must be kept in a place closed to children. Temperature indicators - up to 25 ° С. Do not freeze the gel.

[13], [14], [15], [16]

Shelf life

Remisid is allowed to apply within a 24-month term from the time the substance is manufactured.

[17], [18], [19], [20]

Application for children

Not prescribed in pediatrics.

Analogs

Analogues of the drug are medicines Nimedar and Frenag gel.

[21], [22]