Piascledine 300.

Piascledine is a combination drug containing two active ingredients: avocado fruit oil and soybean oil. This preparation is used in medical practice to treat and reduce the symptoms of osteoarthritis and to maintain healthy joints and ligaments.

Here are some key aspects about each of the active ingredients:

1. Avocado Fruit Oil: Avocado fruit oil extract is often used for medicinal purposes because of its joint-improving properties. It contains phytosterols and unsaturated fatty acids that can help reduce inflammation in the joints and improve mobility.
2. Soybean oil: Soybean oil also contains unsaturated fatty acids such as linoleic acid, which can help reduce inflammation in the body. It may also have beneficial effects on joint and bone health.

Piascledine is available in the form of capsules that are usually taken orally. It may be recommended for patients with osteoarthritis or other joint conditions to improve their condition and reduce pain.

It is important to note that before you start using Piascledine or any other medication, you should consult your doctor, especially if you have any medical conditions or are taking other medications.

Indications Piascledine 300.

1. Osteoarthritis: The drug is used to treat symptoms of osteoarthritis, such as pain, inflammation, and limitation of joint mobility. Piascledine may help reduce inflammation in the joints and improve their function.
2. Maintaining joint health: Piascledine may also be used as an adjunctive treatment to maintain joint health and prevent the progression of osteoarthritis in patients at risk of developing it.
3. Combating deforming joint changes: The use of Piascledine may help reduce the deforming changes in the joints characteristic of osteoarthritis.
4. Improved quality of life: Patients with osteoarthritis may experience pain, limited mobility, and other problems that can significantly reduce their quality of life. The use of Piascledine can help improve these symptoms and increase patients' comfort levels.

Release form

Piascledine 300 capsules: The standard dosage is 300 mg (which is reflected in the name of some versions of the drug), where the ratio of avocado fruit oil to soybean oil is usually 1:2. The capsules are designed to be taken long-term, and positive treatment effects are usually seen after several weeks of regular use.

Pharmacodynamics

1. Anti-inflammatory: Extracts from avocado fruit oil and soybean oil may have anti-inflammatory properties, helping to reduce inflammation in the joints and surrounding tissues. This is especially important in osteoarthritis, where inflammation plays a key role in the development of pain and joint degeneration.
2. Chondroprotective action: Piascledine may help protect the cartilage tissue of the joints by promoting its regeneration and preventing further breakdown. This is particularly useful for slowing the progression of osteoarthritis.
3. Stimulation of mucopolysaccharide synthesis: Mucopolysaccharides are key components of cartilage tissue and synovial fluid. Piascledine may help to increase the synthesis of mucopolysaccharides, which helps to maintain and restore joint function.
4. Antioxidant Action: Avocado fruit oil and soybean oil extracts contain antioxidants that may help protect joints from free radical damage and oxidative stress.
5. Antinecrotic Action: Piascledine may help prevent necrosis of cartilage tissue, which is important for preserving joint function and preventing further destruction.

Pharmacokinetics

1. Absorption: Components from Piascledine are probably absorbed through the gastrointestinal tract after oral administration.
2. Distribution: After absorption, the components may be distributed to organs and tissues of the body through the bloodstream.
3. Metabolism: These components may be metabolized in the liver or other organs.
4. Excretion: Metabolites may be excreted from the body through the kidneys or through the intestines.
5. Half-life: This is the time during which the concentration of the drug in the blood decreases by half, may vary depending on the specific characteristics of each component.

Dosing and administration

It is important to note that dosage and route of administration recommendations should be followed according to the manufacturer's instructions and/or physician's recommendations.

Method of application and dosage:

• Dosage: The standard recommended dose of Piascledine is one capsule per day. Each capsule usually contains 300 mg of active ingredients (a combination of avocado fruit oil and soybean oil).
• How to take: The capsule should be taken with meals, drinking enough water to facilitate swallowing and improve absorption.
• Duration of treatment: Positive effects of Piascledine are usually seen after several months of regular use. Doctors often recommend that you continue taking it for at least three months to evaluate its effectiveness.

Special Instructions:

• Onset of Action: Improvement may occur gradually and it may take time for noticeable results to occur.
• Duration of use: The drug is intended for long-term use, and its safety and efficacy have been confirmed in clinical studies when taken for extended periods.
• Interaction with other drugs: Before starting Piascledine, you should notify your doctor of all other medications you are taking to avoid possible interactions.
• Allergic Reactions: If you are allergic to soy, avocado or any other component of the product, you should consult your doctor before using it.

Use Piascledine 300. during pregnancy

In terms of safety during pregnancy, there may be limited or no human studies focusing on the specific use of Piascledine during pregnancy. Therefore, it is recommended that you discuss the use of Piascledine during pregnancy with your doctor or a doctor specializing in pregnancy and obstetrics.

Your doctor can evaluate the potential risks and benefits of using Piascledine in your particular situation and suggest alternative treatments or joint support that may be safer for pregnant women.

Contraindications

1. Allergies: Some people may be allergic to avocado oil or soybeans, so you should check for allergic reactions to these ingredients before using Piascledine.
2. Pregnancy and breastfeeding: There is limited data on the safety of using Piascledine during pregnancy and breastfeeding, therefore it should be taken with caution and only after consulting a doctor.
3. Gastrointestinal problems: In some people, avocado oil or soybean oil may cause gastrointestinal irritation, which may lead to diarrhea, abdominal bloating and discomfort. Patients with peptic ulcer disease or other gastrointestinal conditions should use Piascledine with caution.
4. Bleedingproblems: Avocado oil and soybean oil may tend to reduce blood clotting. Therefore, people with thrombocytopenia or other bleeding problems should avoid using Piascledine or take it under a doctor's supervision.
5. Pediatric age: There are insufficient data on safety and efficacy of Piascledine in children, therefore its use in children should be supervised by a physician.

Side effects Piascledine 300.

1. Gastrointestinal disorders: Gastrointestinal disorders such as diarrhea, nausea, vomiting, dyspepsia or abdominal pain may occur.
2. Allergic reactions: Some people may have an allergic reaction to the components of the drug. This may manifest as skin rash, itching, hives, facial swelling or even anaphylactic shock.
3. Hypersensitivity: Some patients may experience hypersensitivity to the drug, manifested in various forms, including rash, itching, redness of the skin and other allergic manifestations.
4. Other reactions: In rare cases, headaches, dizziness, changes in taste, fatigue, or insomnia may occur.
5. Interactionswith other medications: Although interactions between piascledine and other medications are usually minimal, you should still tell your doctor about all medications you are taking, including dietary supplements.

Overdose

Piascledine, which contains avocado fruit oil and soybean oil, is generally considered safe when used in recommended doses. However, overdose may lead to undesirable side effects.

Because there is no definitive data on what happens when you overdose on Piascledine, it is important to follow the dosage recommendations on the package or as prescribed by your doctor. If any unwanted symptoms or unusual reactions occur, medical attention should be sought immediately.

Interactions with other drugs

1. Anticoagulants (e.g. Warfarin): Piascledine may have a mild antiaggregant effect due to its content of unsaturated fatty acids such as omega-3. Therefore, concomitant use with anticoagulants may increase the risk of bleeding. It is recommended to discuss this with your doctor.
2. Drugs affecting blood pressure: There may be a slight decrease in blood pressure when foods containing omega-3 fatty acids are consumed. Therefore, caution is advised when co-administered with antihypertensive drugs.
3. Drugs affecting blood clotting: It appears that Piascledine may enhance the antiplatelet properties of aspirin. Caution should be exercised when used concomitantly with other antiplatelet agents such as aspirin or clofibrate.
4. Drugs affecting blood lipid levels: Piascledine contains fatty acids that may affect blood lipid levels. When used concomitantly with drugs for the treatment of hyperlipidemia, it is recommended to monitor blood cholesterol levels and adjust the dosage of the drugs if necessary.

Storage conditions

1. Temperature: Store Piascledine at room temperature, preferably between 15°C and 25°C (59°F and 77°F). Avoid extreme temperatures, such as freezing or overheating, as this may affect the quality of the drug.
2. Light: Avoid direct exposure of Piascledine packaging to sunlight, as light can degrade the active ingredients of the drug.
3. Humidity: Store Piascledine in a dry place to prevent moisture, which may cause deterioration of the drug.
4. Packaging: Before storing, make sure that the packaging of Piascledine is well closed and airtight. This will help prevent moisture and keep the medicine fresh.
5. Children and pets: Keep Piascledine out of the reach of children and pets to prevent accidental use.
6. Shelf life: Follow the manufacturer's instructions regarding the shelf life of Piascledine. The drug may lose its effectiveness after the expiration date.