Pask

Pask has an active antibacterial effect (has a medicinal effect against mycobacteria).

The drug demonstrates an active bacteriostatic effect on M. tuberculosis bacteria. The action of this drug develops by inhibiting the processes of mycobactin formation, and in addition, it occurs by suppressing the processes of B9-vitamin formation. Due to this, the capture of M. tuberculosis microbes by iron is noticeably weakened.

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Indications Paska

It is used in the combined treatment of tuberculosis, which has different forms and localizations. Pask is usually used in people with tuberculosis who are resistant to other anti-tuberculosis elements.

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Release form

The substance can be released in the form of a lyophilisate for injection liquids.

Also available in granules for oral liquid - 5.52g sachets, 25 pieces per box.

It can also be produced in tablets of 0.5 and 1 g.

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Pharmacodynamics

The drug has an effect on relatively actively reproducing mycobacteria, having almost no effect on dormant Mycobacterium tuberculosis. It has a weak effect on pathogenic microbes located inside cells.

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Pharmacokinetics

After oral administration, the drug is well absorbed at a high rate.

It is quickly distributed, penetrating into tissues and all histohematic barriers. It passes into the cerebrospinal fluid only during inflammation of the meninges. Metabolic processes are carried out inside the liver.

Excretion occurs in acetylated form, mainly with urine. Small amounts of the drug component are excreted with breast milk, saliva and bile.

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Dosing and administration

For intravenous injections of the drug, a 3% liquid is administered through a dropper using an injection pump. At first, the injection rate is 30 drops/minute, and then (in the absence of systemic and local negative manifestations) it is increased to 40-60 drops (after 15-20 minutes). At the first injection, the portion size is a maximum of 0.2 l of liquid, and then (if there are no negative symptoms) - 0.4 l. 5-6 injections of the drug are performed per week. A scheme with the introduction of liquid every other day can also be used (on days of the break, the drug is taken orally - in granules or tablets).

The daily dosage for adults is 10-12 g, and for children - 0.2 g / kg. In case of exhaustion or poor tolerance, and in addition to the elderly, 6 g of the substance is administered per day.

The tablets should be taken orally, 0.5-1 hour after meals; they are washed down with alkaline mineral water or milk. For adults, the daily dosage is 9-12 g (divided into 3 doses). For children, it is 2 g/kg per day.

The medicinal powder is prepared into a liquid for oral administration (the lyophilisate from the sachet is dissolved in warm boiled water (0.1 l)). Pask should be consumed half an hour after eating. The prepared solution of the medicine can be stored for a maximum of 1 hour. The average adult dosage of the medicine is 8-12 g per day; it should be divided into several uses.

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Use Paska during pregnancy

Do not use during breastfeeding or pregnancy.

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Contraindications

Among the contraindications:

• severe sensitivity to a medicinal substance;
• liver failure, hepatitis or liver cirrhosis;
• gastric ulcer;
• aggravated phase of enterocolitis;
• amyloidosis affecting internal organs;
• myxedema of an uncompensated nature;
• nephritis;
• decompensated stage of CHF;
• thrombophlebitis or hypocoagulation.

Caution is required when used in epileptics.

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Side effects Paska

Side effects include:

• vomiting with nausea, bloating, constipation or diarrhea, loss of appetite and pain affecting the abdominal area, as well as hyperbilirubinemia or hepatomegaly; proteinuria, hematuria or crystalluria may also develop;
• thrombocytopenia or leukopenia, pernicious anemia or drug-induced hepatitis are occasionally observed;
• allergy symptoms include fever, arthralgia, dermatitis, as well as bronchial spasm or eosinophilia;
• When large doses of the drug are administered or in the case of prolonged use, myxedema, hypothyroidism or goiter develops.

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Overdose

In case of intoxication with the drug, diarrhea and vomiting usually develop. More rarely, in case of severe poisoning with Pask, potentiation of negative symptoms and even psychosis occur.

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Interactions with other drugs

The drug should be used in combination with other anti-tuberculosis medications - this allows to significantly increase the effectiveness of treatment compared to monotherapy. It also significantly reduces the likelihood of tuberculosis mycobacteria developing resistance to the drug.

The introduction of Pasca together with isoniazid increases the therapeutic effectiveness of the course.

Use in combination with streptomycin also potentiates the anti-tuberculosis properties of the drug.

Barbiturates with butadion, when combined with the drug, enhance its medicinal activity.

Combination with diphenhydramine weakens the therapeutic effect of Pask.

It is prohibited to administer the drug together with rifampicin, because this will disrupt the absorption of the latter.

The introduction of the drug leads to potentiation of the activity of aminophenazone and anticoagulants, as well as the toxic properties of diphenin, and in addition, weakens the absorption of cyanocobalamin.

While using the medicine, smoking and drinking alcohol are prohibited.

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Storage conditions

Pask must be stored at a maximum temperature of 25°C.

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Shelf life

Pask can be used for a 3-year period from the date of sale of the medicinal product.

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Application for children

It is prohibited to use in children under 3 years of age weighing less than 20 kg. To ensure a more accurate dosage, Pask is prescribed to children in granules.

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Analogues

The analogs of the drug are the drugs Simpas, Pazer, Aminosalicylic acid and Pasconate, as well as Aquapask, Monopas and PAS Sodium, PAS-Fatol N, MAC-PAS and PAS-Akri.

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Reviews

Pask has received mostly positive reviews and has demonstrated high efficacy when combined with other anti-tuberculosis agents.

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