Paroxetine

Paroxetine is an antidepressant from the SSRI drug group.

[1], [2], [3], [4], [5], [6], [7]

Indications Parrochene

It is used to treat such conditions:

• disturbing violation of a generalized nature;
• socio-phobia;
• panic disorders, including agoraphobia;
• OCD ;
• any form of depression, including reactive, endogenous, and also accompanied by anxiety.

Release form

The release of the drug is sold in tablets, in the amount of 10 pieces inside a blister pack. In the box - 3 such packages.

Pharmacodynamics

The antidepressant effect and therapeutic efficacy of the drug during the treatment of panic disorders and OCD develops by specifically slowing down the capture of 5-hydroxytryptamine by brain neurons. The chemical structure of the drug is different from tricyclics, tetracyclic and other known antidepressants.

The drug has a weak affinity for cholinergic muscarin endings. Paroxetine differs from tricyclics in that it has a weak affinity for α1-, α2-, as well as dopamine (D2), histamine (H1), 5-HT2- and 5-HT1-shaped endings, as well as β-adrenoreceptors.

The drug does not affect the work of the CAS, and in addition does not lead to the development of clinically significant changes in heart rate, blood pressure and ECG values.

The drug is also different from antidepressants that slow down the capture of norepinephrine. It has a much weaker effect on the antihypertensive properties of guanethidine.

Pharmacokinetics

The active element of the drug at a high speed is absorbed from the gastrointestinal tract, and then subjected to intrahepatic metabolism. The substance undergoes an extensive tissue distribution (only 1% of the drug is detected inside the plasma). Protein synthesis - 95%.

About 64% of the drug excreted in the urine, and another 36% is excreted in the bile through the intestines. Less than 1% of the drug is excreted unchanged.

Indicators of the active component of Paroxetine are increased in the elderly and people with problems in the liver or kidneys.

Dosing and administration

It is necessary to use medicine 1 times a day, together with food; pills do not chew, but swallow, washed down with ordinary water. Within a period of 14-21 days, the dosage is selected separately for each patient, adjusting it later.

When depression should be consumed 1 times a day for 20 mg of the substance. An increase in servings is allowed when required (+10 mg per day), but not more than 50 mg per day.

For the treatment of OCD, at the initial stage, 20 mg of the substance is consumed per day, and later the dose is increased - daily + 10 mg, while the daily dosage will not be 40 mg.

In the case of alarming disorders, having a generalized nature, they take 20 mg of medicine per day. To prevent the appearance of withdrawal syndrome, it is necessary to stop the use of drugs gradually.

For the treatment of social phobia or socially disturbing disorders should be consumed every day for 20 mg of the drug. If there is no result after 14 days of taking the medication, the portion is increased (the daily maximum is 50 mg). The dosage is increased weekly, by 10 mg.

For the treatment of panic disorders, first use 10 mg of the drug per day, after which they increase the serving every day by 10 mg, until it reaches 40 mg.

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Use Parrochene during pregnancy

It is forbidden to use the drug during pregnancy.

Contraindications

Among the contraindications:

• the presence of strong sensitivity in relation to the components of the drug;
• breastfeeding period;
• epilepsy, which is unstable;
• combined use with IMAO (and within the period of 14 days after the cancellation of their admission).

Caution is required when used in such cases:

• bleeding disorders;
• concomitant use with bleeding medications;
• during electropulse treatment;
• epilepsy or seizures;
• prostatic hyperplasia;
• heart disease;
• mania;
• glaucoma of a closed angle;
• liver or kidney failure

Side effects Parrochene

The use of a drug may cause the development of some adverse symptoms:

• disorders of antidiuretic hormone release processes, hyperhidrosis, as well as hyponatremia;
• urticaria, rash of allergic origin, angioedema and ecchymosis;
• orthostatic collapse;
• constipation or diarrhea, vomiting, hepatitis, dryness of the oral mucosa, taste disorder, nausea, weakening or increased appetite;
• hyperprolactinemia or galactorrhea, as well as anorgasmia and sexual disorders, including impotence and problems with ejaculation;
• delay or increased urination processes;
• feeling of muscle weakness, myopathy, myoclonia, arthralgia or myalgia;
• visual disturbance;
• anxiety, confusion, nervousness, fatigue or drowsiness. Amnesia, agitation, hallucinations, panic attacks and a feeling of depersonalization, as well as mania, convulsions, insomnia, extrapyramidal disorders and dizziness. In addition, also tremor, serotonin intoxication and asthenia.

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Overdose

Intoxication can cause vomiting with nausea, bradycardia, nodal rhythm, seizures, hyperhidrosis, sinus tachycardia, and in addition agitation, feelings of drowsiness or irritability, nystagmus, mydriasis, dryness of the oral mucosa and an increase in blood pressure values.

A single (mainly when combined with other psychotropic drugs or alcoholic beverages) shows changes in ECG readings or coma.

Severe poisoning leads to the development of serotonin intoxication, and also, sometimes, to rhabdomyolysis.

Interactions with other drugs

Combination with warfarin can cause a hemorrhagic syndrome.

It is forbidden to consume alcoholic beverages during treatment with Paroxetine.

Combination with antiarrhythmic drugs of the 1st class (such as propafenone or flekainid), sumatriptan, fluoxetine and thioridazine increases the likelihood of negative symptoms.

Phenobarbital with primidone reduces the bioavailability of the drug. The drug itself suppresses the metabolic processes of tricyclics (such as imipramine with desipramine, as well as amitriptyline) and astemizole, increasing their blood values and increasing the likelihood of adverse events.

This drug is incompatible with tryptophan, lithium salts and MAOI (this includes procarbazine and furazolid with selegiline). Antacids do not affect the degree of absorption of drugs.

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Storage conditions

Paroxetine is required to be kept in a place protected from sunlight. Temperatures - within 25 ° C.

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Shelf life

Paroxetine can be used within 36 months of the manufacture of the therapeutic agent.

Application for children

The use of paroxetine in pediatrics is prohibited.

Analogs

Analogues of drugs are drugs such as Rexetin with Paxil and Adepress.

Reviews

Paroxetine is considered to be a fairly effective medicine - expert reviews indicate a good result of its exposure and the rare appearance of negative signs. It is also recommended to take into account that the drug has an effect on coordination, which is why it cannot be used by drivers and people with an active lifestyle.