Paramin

Paramin is an anti-tuberculosis drug.

Indications of the paramina

It is used for the treatment of active forms of tuberculosis, which is at a progressive stage (mainly pulmonary tuberculosis of a chronic nature, with a fibrous-cavernous form).

[1]

Release form

Release of the drug occurs in granules - 100 g inside the container. The pack contains 1 such container.

[2]

Pharmacodynamics

The active element of the drug is sodium aminosalicylate. The drug has a bacteriostatic effect against tuberculous mycobacteria.

Often, Paramin is combined with other anti-tuberculosis drugs (such as tubazid and other drugs GINK, and in addition kanamycin with cycloserine).

Due to complex treatment, it is possible to delay the development of drug addiction and to increase the therapeutic effect of antituberculous drugs.

When used in large portions, the drug has an antithyroid effect.

Pharmacokinetics

After oral administration, the drug is perfectly absorbed, passing inside the blood serum and tissues of various internal organs.

Metabolism for the most part occurs inside the liver, 0.5-1 hour after the application of the drug. At the same time, the processes of acetylation of the element and its binding to glycine are carried out.

During the day, along with urine, about 90-100% of the portion consumed is excreted.

Dosing and administration

The medicine should be taken 30-60 minutes after eating, at the same time washing down the granules with mineral water or milk.

The size of the adult dose is 5 grams of medication, with a 2-3-fold intake per day.

For children, the portion size is calculated according to the scheme of 0.2 g / kg of preparation per day. This portion should be divided into 3-4 uses.

The dosage rate for children weighing from 40 kg is 5 g of substance with twice daily intake.

If the patient does not tolerate taking drugs, it is necessary to reduce the size of his dosage.

Treatment lasts a minimum of 3-5 months. If necessary, it can be extended.

[5]

Use of the paramina during pregnancy

Use Paramin during pregnancy is prohibited. Also, you should stop breastfeeding while taking the medication.

Contraindications

Among the contraindications:

• renal (nephritis) or hepatic (cirrhosis or hepatitis) pathology in pronounced form;
• amyloid dystrophy;
• presence of an ulcer;
• hypothyroidism;
• decompensation of cardiac function;
• hypothyroidism.

[3]

Side effects of the paramina

Also a weakening of appetite and abdominal pain. There may be allergy symptoms, including fever, hives, joint pain, enanthema, eosinophilia, purpura and asthmatic symptoms.

There may be the appearance of pain and enlargement of the liver in size.

The above symptoms often go away after a reduction in the dose or a short-term suspension of drug use. They have a weaker severity, if you take the medicine in accordance with the instructions and against a background of regular three meals a day.

To eliminate the symptoms of allergies, use antihistamines, vitamin C and CaCl2. If prolonged allergic symptoms are observed, corticosteroids are used. It is also necessary to consider the likelihood of developing phlebitis or bruising.

[4]

Overdose

Given the nature and severity of symptoms of poisoning, drug use should be stopped for a short period, or completely abandoned.

To eliminate the disorders use CaCl2, antihistamines and vitamin C, and in case of prolonged violations - corticosteroids.

Interactions with other drugs

Paramin increases isoniazid values inside the blood, as it competes with it for joint metabolic pathways.

The drug disrupts the absorption of substances such as erythromycin with rifampicin, as well as lincomycin.

It interferes with the assimilation of cyanocobalamin, which as a result can lead to the appearance of anemia.

[6]

Storage conditions

Paramin should be kept in a dark place, closed from children. Temperature values - no more than 25 ° С.

Shelf life

Paramin may be used for 3 years from the date of manufacture of the therapeutic agent.

Application for children

Due to the complexity of the dosing regimen, medicines should not be given to children weighing less than 10 kg.

[7], [8]

Analogues

Analogues of the medication are Monopas, Sodium Aminosalicylate and Pasconate, as well as Paramin-Health, Paska, Paz and Paz sodium, and also Pask sodium salt.