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Onagris
Last reviewed: 04.07.2025
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Onagris is a medicine used to treat various diseases related to sexual function. It acts as a hormone of the sex glands.
This is a natural remedy that helps with menopause - both for its treatment and as a preventative measure. It helps eliminate the negative symptoms that occur during menopause: hot flashes, insomnia, heavy sweating at night and irritability. At the same time, it improves the condition of the epidermis (has a moisturizing effect) and hair (reduces hair loss), and also prevents dryness of the vaginal mucosa.
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Indications Onagrisa
It is used for climacteric disorders, due to which vegetative symptoms (hot flashes, variability of blood pressure, feeling of heat and palpitations), psychosomatic and mental manifestations (feeling of irritability, insomnia and deterioration of performance) develop.
Onagris is used in combination regimens to prevent the development of cardiovascular diseases and osteoporosis, which occur due to a lack of estrogen during the early phase of menopause.
Release form
The medicinal substance is released in capsules - 15 pieces per package, 2 packages per box, or 20 pieces per plate, 3 plates per pack.
Pharmacodynamics
The therapeutic effect of the drug develops due to the estrogen-like activity of soy isoflavonoid derivatives (components of daidzein and genistein).
Soy phytoestrogens have a diphenolic structure, which is observed in natural and artificial estrogens, due to which they can compete with them for the corresponding endings inside the walls of target cells.
The principle of the drug's effect is related to the effect of phytoestrogens on β-estrogen endings (mainly); however, the effect on α-estrogen endings is 5-22 times weaker. Because of this, Onagris causes much less negative symptoms related to the effect on α-estrogen endings (uterine bleeding, hypercoagulation, endometrial hyperplasia, thromboembolic complications, as well as changes related to the mammary glands), which distinguishes it from artificial estrogen drugs.
Pharmacokinetics
After oral use, soy isoflavonoids begin to actively act in the colon, breaking down the sugar region under the influence of glycosidase enzymes of the intestinal microflora.
After undergoing the deglycosylation process, daidzein and genistein are well absorbed and penetrate into the liver, where partial conjugation of the element with glucuronic acid occurs. In this case, the conjugated phytoestrogen fraction penetrates into the bile, and then into the structure of the intrahepatic circulation, undergoing repeated absorption, due to which the drug has a long half-life and the possibility of 1-time use per day.
Plasma Cmax values of phytoestrogens are 0.04-2.4 μmol/l, depending on the diet followed (the indicator increases if the patient is a vegetarian, consuming products with a high soy content).
Excretion of daidzein with genistein occurs to a greater extent with urine. Cmax values of phytoestrogens in urine are noted after 24 hours from the moment of drug use. About 30% of the taken isoflavonoids are excreted unchanged.
Dosing and administration
The medicine is taken 1 capsule per day. The clinical effect usually develops after 14 days from the start of therapy. If the symptoms of the disease are weakly relieved, the daily dose is increased to 2 capsules: one in the morning and one in the evening. Such a therapeutic course should last at least 4 months.
In order to fully control the manifestations of estrogen deficiency, and in addition to this, when used in combination to prevent the development of osteoporosis and cardiovascular diseases, the drug can be used for a long time (within 4-7 years). If long-term use is required, it is necessary to first consult a medical specialist.
Use Onagrisa during pregnancy
Soy phytoestrogens should not be prescribed during breastfeeding or pregnancy.
Contraindications
Main contraindications:
- severe sensitivity to medicinal elements;
- tumors in the mammary glands and uterus that are malignant in nature (before radical therapy).
Side effects Onagrisa
The medication is usually tolerated without complications, and side effects develop only occasionally.
Sometimes dyspeptic disorders appear – pain in the abdominal area, bloating and diarrhea.
Signs of allergy, vaginal discharge (sometimes with blood), uterine bleeding, hypercoagulation, as well as complications of a thromboembolic nature, endometrial hyperplasia and changes associated with the mammary glands may occur.
If negative symptoms appear, it is necessary to consult a medical specialist regarding the advisability of further use of the drug.
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Overdose
Soy phytoestrogens are not toxic, which is why even a significant overdose is unlikely to lead to the appearance of pronounced signs of intoxication. Dyspeptic disorders and headaches occur sporadically.
In such disorders, it is necessary to monitor the patient's condition and carry out symptomatic measures.
Storage conditions
Onagris should be stored in a place closed to small children. Temperature level – within 30°C.
Shelf life
Onagris can be used for a period of 24 months from the date of sale of the pharmaceutical product.
Application for children
Onagris is not used in pediatrics.
Analogues
The analogs of the drug are the substances Tsimitsiplant, Danol with Mastodynon, and also Klimadinon, Cyclodynon and Mammoleptin.
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Attention!
To simplify the perception of information, this instruction for use of the drug "Onagris" translated and presented in a special form on the basis of the official instructions for medical use of the drug. Before use read the annotation that came directly to medicines.
Description provided for informational purposes and is not a guide to self-healing. The need for this drug, the purpose of the treatment regimen, methods and dose of the drug is determined solely by the attending physician. Self-medication is dangerous for your health.