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Oletetrin is a systemic antibacterial drug. Included is a group of combined tetracyclines.
Indications of the olettrin
It is indicated for the elimination of infectious processes provoked by pathogens sensitive to the drug:
- infection in the lower and upper parts of the respiratory system, as well as ENT organs: tonsillitis with sinusitis, pharyngitis and laryngitis. In addition, angina, bronchitis, inflammation of the middle ear, pneumonia and bronchiectasis;
- infections of the organs of the urogenital system: cystitis, gonorrhea with pyelonephritis, as well as prostatitis and endometritis;
- infections in the gastrointestinal tract: pancreatitis with cholecystitis;
- infectious pathologies: tularemia and meningitis, as well as rickettsiosis and brucellosis;
- osteomyelitis;
- erysipelas and infections in the area of soft tissues with skin.
Oletetrin can be used in the prevention or treatment of complications that develop after surgery.
Pharmacodynamics
The drug contains in its composition 2 antibiotics - oleandomycin and tetracycline. It has bacteriostatic properties.
Oleandomycin with tetracycline are antibiotics with a wide range of effects. Their properties are due to the slowing down of the binding processes of microbial proteins at the ribosomal level (the formation of bonds between peptides, as well as the growth of chains of polypeptides).
The drug effectively affects the following gram-positive microbes: streptococci and staphylococcus, diphtheria corynebacterium and anthrax bacillus. It also acts against gram-negative microbes: gonococci, influenza sticks, pertussis, Brucella spp., Legionella, enterobacter and klebsiella. In addition, it acts on anaerobes (clostridia) and other bacteria: mycoplasma, ureaplasma urealitikum, chlamydia, rickettsia and Spirochaetaceae.
Resistance of bacteria with respect to drugs develops much more slowly than in the case of separate application of oleandomycin and tetracycline.
Contraindications
Among the contraindications of drugs:
- increased sensitivity to antibiotics-tetracyclines or macrolide drugs, and in addition to any constituent elements of the drug;
- children under 12 years of age;
- severe forms of disorders in the work of the kidney or liver;
- presence of leukopenia.
Side effects of the olettrin
The use of the drug can provoke the development of certain side effects:
- Gastrointestinal organs: development of diarrhea, anorexia, vomiting, dysphagia, abdominal pain, nausea, constipation and esophagitis with glossitis. Occasionally, there may be abnormalities in liver function, transient increase in liver transaminase activity, as well as parameters of alkaline phosphatase, residual nitrogen and bilirubin;
- allergic manifestations: itching, rash on the skin, Photosensitivity and edema Quincke;
- organs of the National Assembly: the appearance of headaches or dizziness;
- change in the values of laboratory tests: development of thrombocytopenia or neutropenia, as well as hemolytic form of anemia and eosinophilia;
- reactions that arise due to chemotherapeutic procedures: the development of intestinal dysbiosis, as well as candidiasis;
- Other: children may have darkening of tooth enamel. There may be a deficit of vitamins from category B, as well as K.
Dosing and administration
Oletetrin should be taken in the amount of 250 mg (1 capsule) four times a day (dosages are calculated for adolescents over 12 years and adults). Use the capsule before meals (half an hour), without chewing. Wash down with water (150-200 ml).
For a day, you can take no more than 2000 mg of medication.
The duration of the therapeutic course depends on the severity of the pathology, as well as its course and drug efficacy. On average, it is 5-10 days.
Interactions with other drugs
Medicines that contain magnesium, calcium, aluminum and iron (such as iron and antacids) and, in addition, colestipol with cholestyramine reduce the absorption of oletetrin. Therefore, with their combined application, it is required to withstand intervals of 2 hours between doses.
The medicine can not be combined with antibiotics that have bactericidal properties.
A combination with retinol increases the likelihood of increased intracranial pressure.
Combination with anticoagulants may require correction of the dosage of antithrombotic drugs. When combined with hormonal contraception, there is a weakening of their effectiveness, and the likelihood of bleeding in the uterus increases.
Attention!
To simplify the perception of information, this instruction for use of the drug "Oletketrin" translated and presented in a special form on the basis of the official instructions for medical use of the drug. Before use read the annotation that came directly to medicines.
Description provided for informational purposes and is not a guide to self-healing. The need for this drug, the purpose of the treatment regimen, methods and dose of the drug is determined solely by the attending physician. Self-medication is dangerous for your health.