Ointments with antibiotic for wounds

To eliminate inflammation and purulent lesions use different drugs with antibiotic. Consider the popular ointments that are effective for wound damage to the skin.

From early childhood, we encounter different skin lesions. To ensure that the healing process passed quickly and did not cause various complications, wound healing agents are used. Minor cuts, scratches and abrasions do not require special treatment, but if the wound occupies a large area of the skin, then an ointment with an antibiotic is needed.

Antibacterial topical agents are necessary for infectious damage, when the suppuration began. They have a wide spectrum of action, they destroy pathogens. The best option for treatment is wound healing ointment with an antibiotic. It helps in the treatment of eczema, chemical and thermal burns, inflammatory-purulent diseases. And also with bacterial infection after surgery.

When choosing a drug, it must be taken into account that they are classified according to the etiology and stage of the wound process. So in the inflammatory process, antiseptics and antimicrobial ointments are used. At deep wounds shows antibacterial medications with analgesic effect.

[1], [2], [3], [4], [5], [6]

Indications for the use of ointments with antibiotic for wounds

Skin is an organ that performs protective functions and prevents the penetration of pathogenic viruses, bacteria, and infection into the body. Indications for the use of ointments with antibiotic for wounds are based on violation of the integrity of the dermis. Consider when to use the medicine:

• Deep cuts and scratches.
• Purulent wounds.
• Abrasions.
• Burns of different etiology.
• Crack on the skin with suppuration (on the fingers, heels, elbows).
• Trophic ulcers.
• Ulcers.
• Erosion.
• Chronic dermatosis.

Ointments with antibiotics can contain wound healing substances, which accelerate the process of tissue regeneration. Use the medicine better for medical purposes, especially if the wounds are deep and there is a risk of their suppuration.

Pharmacodynamics

About how effective this or that medication can be learned from its pharmacodynamics. Consider the mechanism of action of ointments with an antibiotic for wounds from different pharmacological groups: tetracyclines and levomycetins.

• Tetracycline ointment

Bacteriostatic effect of the drug is based on the violation of complexation between the ribosome of the infectious cell and transport RNA, which leads to inhibition of protein synthesis. It shows a pronounced activity in infectious lesions of the epidermis, caused by gram-positive, gram-negative microorganisms. It shows no pharmacological activity to most strains of Bacteroides spp., Beta-hemolytic group A streptococci, fungi and viruses due to the established resistance of these pathogens to the active substances of the drug.

• Levomexol

Combined drug with antibiotic - chloramphenicol and immunostimulating substance - methyluracil. It is active against many bacteria, chlamydia, rickettsia and spirochetes. Its bacteriostatic effect is caused by the inhibition of protein biosynthesis in the bacterial cell.

Effective in gram-positive aerobic and anaerobic bacteria, gram-negative microorganisms. The peculiarity of this medication is that the development of resistance of harmful microorganisms to its action is slow. Affects the regeneration of tissues, has anti-inflammatory properties.

Pharmacokinetics

The therapeutic properties of topical drugs depend not only on their active composition, but also on their pharmacokinetics. Most ointments, after application on the skin are quickly absorbed and produce a therapeutic effect.

As a rule, the drugs do not have systemic absorption, so they do not penetrate into the blood, rendering local action. Long-term use can cause the stability of harmful microorganisms. In this case, you need to change the drug.

Names of ointments with antibiotic for wounds

Various skin lesions are a problem known to everyone. To date, there are many drugs for the treatment of wounds and abrasions. It is recommended to use ointments with antibiotics to prevent infection and accelerate healing. The choice of the drug depends on the level of damage: skin wounds, subcutaneous tissue damage, deep lesions (superficial fascia, muscles, fascial structures).

The doctor must prescribe the medicine. Since its effectiveness depends on the etiology of wound infection. Most often encounter such pathogens: staphylococci, non-fermenting gram-negative bacteria, hemolytic and non-hemolytic streptococci, obligate non-spore-forming anaerobic microorganisms and others.

Consider the popular names of ointments with antibiotic for wounds, their classification and instructions for use:

Aminoglycosides

1. Baneocin

Combined antimicrobial agent for external use. It consists of antibiotics (neomycin sulfate, bacitracin) with synergistic properties that destroy bacteria. It is active against most gram-positive and gram-negative microorganisms, fusobacteria and actinomycites.

Prevents the development of hypersensitivity to the drug and gives a therapeutic effect from the first days of use.

• Indications for use: treatment and prevention of skin damage and diseases, superficial wounds, burns, bacterial infections, secondary infections. Effective in the postoperative period, in otolaryngology and in pediatric practice with diaper dermatitis.
• Before applying to the skin, it is advisable to check the sensitivity response. The agent is applied to both the affected area of the skin and under the bandage, since it increases its effectiveness by a thin layer 2-3 times a day.
• Baneocin is contraindicated for hypersensitivity to active components, severe damage to the dermis, impaired renal excretion (at risk of systemic absorption). With extreme caution appoint during pregnancy and allergic reactions in the anamnesis.
• Side effects occur in rare cases. Patients encounter reddening and dry skin, rashes and itching at the site of application. Adverse allergic reactions proceed according to the type of neuro-allergic inflammation. High doses cause absorption and systemic adverse reactions. Most often this development of superinfection.

2. Gentamicin Sulfate

The drug with a wide spectrum of antimicrobial action, suppresses the growth of many gram-positive and gram-negative microorganisms.

After application on the skin, it is rapidly absorbed and has a wound healing effect.

• Apply for skin lesions of varying severity and etiology. Helps with surgical infections, purulent wounds, infections, dermatitis, trophic ulcers, burns. The agent is applied to the affected areas 2-3 times a day, the course of treatment is 7-14 days.
• Contraindicated with intolerance of active ingredients. Side effects occur rarely and manifest as skin allergic reactions.

[13], [14], [15], [16]

Levomycetins

3. Fulevil

Suitable for the treatment of wounds of varying severity, inflammatory skin lesions, pressure sores, I-II degree burns and rectal cracks. The agent is applied a thin layer on a sterile tissue and applied to a pre-treated wound. The dressings are changed every 24 hours. Duration of treatment is 7-21 days. Fulevil is not recommended for use with hypersensitivity to levomycetin. May cause rapid burning and flushing.

4. Levomexol

A combined agent with an immunostimulating substance - methyluracil and an antibiotic - chloramphenicol. Ointment is effective against most bacteria, spirochetes, rickettsia, chlamydia, gram-positive and gram-negative, anaerobic and aerobic microorganisms.

Bacteriostatic effect is based on inhibition of protein biosynthesis in a bacterial cell. If there is pus in the wound, this does not reduce the antimicrobial effect of the antibiotic. Accelerates the regeneration process, has dehydrating properties.

• The medicine is effective in purulent wounds, burns, purulent-inflammatory dermatological diseases, trophic ulcers, boils. The drug is applied to sterile wipes and applied to wounds or injected directly into the purulent cavity with a syringe.
• It is forbidden to use for intolerance of active ingredients, during pregnancy of breast-feeding. It can cause skin allergic reactions that do not require treatment, as they pass by themselves.

Lincosamides

5. Lincomycin Ointment

Antibiotic with the active substance - lincomycin. Has antimicrobial effect. It is used for purulent wounds and pustular skin / soft tissue diseases. Before applying it, it is necessary to clean the wound from pus and necrotic contents. The agent is applied a thin layer on the skin 1-2 times a day.

Contraindicated to use in diseases of the kidneys and liver, with extreme caution in patients with allergic reactions in the anamnesis. Long-term use can cause side reactions: skin rash, itching, hyperemia. To eliminate them, you must stop treatment and seek medical help.

Macrolides

6. Erythromycin ointment

Effective agent for the treatment of infected wounds, pustular lesions of the skin and soft tissues, decubitus, infections of mucous membranes, burns of II and III degree, slowly healing skin defects. Use 2-3 times a day, applying both to the wound and under the bandage.

Duration of treatment from 2-3 weeks to 4 months. Side effects occur rarely and are manifested as mild irritation.

Tetracyclines

7. Tetracycline ointment 3%

Antibiotic for external use, is active against many pathogens. Suppress the growth and multiplication of bacterial cells.

Has a pronounced pharmacological activity in infectious lesions of the epidermis, caused by gram-positive and gram-negative microorganisms.

• Indications for use: infectious and inflammatory lesions of the skin and subcutaneous tissue, deep and long-healing wounds, eczema, folliculitis, furunculosis, acne, infections with productive purulent exudation.
• The drug is applied a thin layer on the affected areas, capturing part of the healthy tissue. Appliques are done 1-2 times a day or apply a bandage for 12-24 hours. The course of therapy depends on the severity of the wound and can last from 1-2 days to 2-3 weeks.
• Side effects are manifested as skin allergic reactions: itching, burning, hyperemia. Not suitable for hypersensitivity to active components. With special care appoint for the treatment of wounds in patients of childhood and pregnant

Antibiotics of other groups

8. Bactroban

Antimicrobial agent with the active substance - mupirocin, a broad-spectrum antibiotic. Inhibits the synthesis of bacterial cells, has a bacteriostatic effect, and increased dosages - bactericidal.

The drug is active against Streptococus spp., Staphyloccocus aureus, Staphyloccocus epidermidis and other harmful microorganisms.

• Bactroban is prescribed as a local therapy for patients with bacterial infections of soft tissues and skin. With re-infected wounds, furunculosis, folliculitis and other dermatological pathologies.
• Since the agent is indicated for topical administration, systemic absorption is negligible. When the ointment is applied to the pressure bandages, the therapeutic effect is increased, as the penetration of the active component into the tissue intensifies. The medicine is applied a thin layer on the skin up to 3 times a day. The recommended duration of treatment is 7-10 days.
• The drug is well tolerated by patients. In some cases, there are undesirable effects in the form of skin itching, burning, hives, dry skin, eczema, hyperemia, erythema. There may be attacks of nausea, allergic reactions and headaches.
• Do not use if hypersensitivity to components for the treatment of children younger than 2 years. If you accidentally swallow the product, you must rinse the stomach, take enterosorbents and seek medical help.

9. Heliomycin

Antibiotic with vasoconstrictive action. It is active against gram-positive microorganisms and viruses, is low-toxic. It is used for extensive wounds, purulent inflammation of the skin, infected eczema. Suitable for the treatment of adults and infants.

Before use, it is recommended to determine the sensitivity to the active ingredients. Apply a thin layer on the affected areas 1-2 times a day for 5-7 days. The agent is applied both to the wound surface and under the bandages.

10. Tyrosur

Antimicrobial topical agent. Antibacterial activity is based on cyclic and linear polypeptides that form endotoxin. The active substance is tyrotricin. The drug is effective against gram-positive and gram-negative microorganisms, pathogens of gonorrhea, yeast fungi, trichomonads.

Tirotricin destroys bacterial walls, changing the permeability of the cytoplasmic membrane, inhibiting cell division and growth.

• Effectively removes pain, does not form a fat film on the skin, reduces the amount of pus and exudate that is separated from the wound. Due to this, its purification from fibrin is improved and the regeneration processes are enhanced.
• Indications for use: wounds, infectious and inflammatory lesions of soft tissues and skin, caused by microbes sensitive to the active substance. Helps with erosion, ulcerative defects, burns, purulent inflammation, infected eczema.
• Ointment is used externally, applying a thin layer on the altered skin areas 2-3 times a day, can be applied under the bandage. It is transferred well, in rare cases, there are local allergic reactions (mild burning, redness), which pass on their own. Contraindicated use when hypersensitivity to the components during pregnancy and lactation.

11. Fusiderm

Antibacterial drug with the active substance is fusidic acid. It is active against corynebacteria, bacterioids, strains of Staphylococcus aureus, Staphylococcus epidermidis, meningococci and other infectious agents.

Has a pronounced anti-inflammatory, antiallergic, antipyretic and anti-exsudative effect. After application on the skin quickly penetrates into the deep layers of the dermis, systemic absorption is minimal.

• Assign for wound and infectious changes in skin. Effective in primary and secondary pathological processes, folliculitis, dermatitis, acne, impetigo, burns. Apply a thin layer with an interval of 8-12 hours. Duration of treatment is 7-10 days. Can be used for occlusive dressings.
• It is contraindicated to use with fusidic acid intolerance, infectious skin changes caused by microorganisms not sensitive to the drug. It is not used during pregnancy and lactation.
• Side effects are manifested in the form of burning, itching, tingling and erythema on the site of application. There are allergic changes in the type of eczema, dermatitis, development of atrophic changes in the skin.

Ointment with antibiotic for wound healing

Human skin very often exposes all kinds of injuries, leaving wounds, scratches, cuts and other defects. In some cases, they need to use medicines to treat them. An ointment with an antibiotic for wound healing accelerates regeneration and prevents the development of infectious processes. In most cases, such drugs have a combined composition, so they have anti-inflammatory, antimicrobial and analgesic effects.

The drug is chosen based on the severity of the lesions. Good antimicrobial and healing properties are possessed by such preparations:

1. Nitacid

Local remedy with pronounced antimicrobial properties. It contains antibacterial substance nitazole and sulfonamide. The components are active against a wide range of Gram-positive and Gram-negative bacteria, multidrug-resistant strains. It has an anti-inflammatory, drying and purifying effect, absorbs purulent-necrotic masses. Penetrates into the deep layers of the dermis, reducing the risks of secondary infection.

• Indications for use: treatment of infected wounds of any severity, purulent-inflammatory diseases of soft tissues and skin. The remedy is effective for deep burns of II-IV degree. Before applying to the skin, the wound surface is recommended to be treated with hydrogen peroxide. You can apply both on the wound and under the bandage 1-2 times a day. The duration of treatment depends on the results achieved in the first days of therapy.
• Side effects occur with intolerance of active substances. Most often, patients face allergic reactions: urticaria, contact dermatitis, hyperemia, pruritus, and Quincke's edema. For their elimination, symptomatic therapy is used.
• Prolonged use of Nitacid may provoke symptoms of an overdose. Similar reactions occur when the medicament is applied to large areas with a violation of their integrity. Due to systemic absorption there is itching, burning and signs of intoxication.

2. Rescuer

Combined drug with synergistic properties. It has a regenerating, softening, analgesic, anti-inflammatory and antiseptic effect. It stops the inflammatory process, has a strong antibacterial effect.

Stimulates the cleansing of the wound surface and the natural restoration of the damaged dermis. The clinical effect is manifested after a couple of hours after use.

• Indications for use: treatment of superficial and deep wounds, abrasions, bruises, cracks, subcutaneous tissue damage, burns, intertrigo, dermatitis of various origins, inflammation of the mucous membranes and skin, secondary infections.
• Before applying the Rescuer to the wound, it must be rinsed and dried. A small amount of the product is evenly distributed on the skin and covered with a bandage to enhance its action. Periodically, the wound needs to be opened to access oxygen. The dressings change 1-2 times a day.
• Contraindicated use with individual intolerance of the active ingredients. Adverse reactions manifested in the form of burning, itching, redness, swelling at the site of application. In addition, the inflammation may worsen when applied to chronic lesions with a trophic disorder.

3. Actovegin

A drug for accelerating the regeneration of tissues and improving trophism.

The active ingredient is deproteinized hemoderivat from calves' blood. The antihypoxant accelerates the metabolism of oxygen and glucose, which increases energy metabolism and accelerates the healing process.

• Assign for wounds and inflammatory diseases of the skin, mucous membranes. Helps with burns (chemical, thermal, solar), abrasions, cracks and scratches. It can be used with bedsores, skin lesions with radiation, and also with wet ulcers.
• Duration of treatment is 10-12 days, the agent is applied to the skin 2 or more times a day. You can use bandages and gauze tampons. Long-term therapy or the use of high doses provokes side effects - skin allergic reactions.

All the ointments with the antibiotic described above for wound healing are released without a medical prescription. But before buying such a remedy, it is necessary to understand that treatment at home is possible with small wounds, scratches, abrasions, cuts or minor burns. Larger damage requires medical attention.

The speed of healing depends on the regenerative characteristics of the patient's body. Some diseases can provoke long healing. For example, with elevated blood sugar or impaired metabolism, treatment will be long. That's why the drugs must be selected by the doctor, individually for each patient.

Ointments with antibiotics for purulent wounds

A purulent wound is a damage to the skin and soft tissues that are involved in the infectious process with the development of pathogenic microorganisms. Bacteria provoke the withdrawal of purulent masses, necrosis, puffiness, pain and intoxication of the body. A similar pathological condition can be a complication of an infected wound or breakthrough of an internal abscess. The risk of its development significantly increases with somatic diseases (diabetes mellitus) and in the warm season.

The purulent process develops due to infection of the wound with streptococci, staphylococci, E. Coli or any other bacteria. Microbes enter the wound from dirty hands, earth, indicating primary infection. If there were non-compliance with the rules of dressing, then harmful microorganisms can enter the body, causing foci of suppuration - secondary infection.

When detecting purulent wounds on any part of the body, treatment should be started immediately. Inadequate or late therapy can cause serious complications (sepsis, periostitis, osteomyelitis) or development of a chronic process. Treatment should be comprehensive and consist of the following stages:

• Removal of necrotic tissues and pus
• Kupirovanie inflammatory process and puffiness
• Removal of pathogenic microflora
• Stimulation of regeneration
• Detoxification and immunocorrective measures

The onset of a purulent process is characterized by the release of exudate from the wound. This liquid contains cellular elements and bacteria. The treatment is based on constant washing, drainage and use of antibacterial drugs that accelerate the regeneration of the skin.

An ointment with antibiotics for purulent wounds stops the reproduction of bacteria, stops the inflammatory process, removes exudate, restores damaged tissues. There are preparations of local and systemic action, they are selected depending on the severity of the lesion. Since at the initial stages of treatment the causative agent of infection is not known, then medicines of a wide spectrum of action are applied: penicillins, tetracyclines, cephalosporins.

Dosing and Administration

Since the ointment refers to topical products, this indicates that it needs to be applied to damaged areas of the skin. The method of administration and dose depend on the severity and stage of the wound process. As a rule, the medicine is used 1-3 times a day.

Medication is applied a thin layer on the damaged skin, impregnate them with gauze wipes, laying in deep wounds, or put under a bandage. The duration of therapy is determined by the attending physician and depends on the individual regenerative characteristics of the organism. On average, the drug is used for 7-20 days, with deep and complex wounds 4-6 months.

[17], [18], [19], [20], [21], [22], [23],

Using ointments with an antibiotic for wounds during pregnancy

No one is immune from damage to the skin. If this happens in expectant mothers and there is a risk of infection, then you need to choose the most effective and at the same time safe drug.

The use of ointments with antibiotic for wounds during pregnancy is possible only for medical purposes. This is due to the fact that most medicines do not have reliable information on the safety of their use in this period. Some medicines of combined action can penetrate into the systemic blood stream, having a negative impact on the development of the child's body. Most often, women are prescribed tetracycline ointment and Levomekol.

Contraindications for use

Not all antibacterial ointments for wounds can be used alone. A quick and persistent therapeutic effect is possible if the patient has sought medical help and received recommendations or an appointment. Otherwise, the medicine can cause serious complications and worsen the condition. This is because any pharmacological agent has contraindications to the use.

Ointments with antibiotics are not allowed for hypersensitivity to active components. Some are contraindicated for pregnant women, with breastfeeding, for patients of childhood and in the presence of allergic reactions in the anamnesis. A number of wound-healing drugs are not used on skin with chronic infection.

[7], [8], [9], [10], [11], [12]

Side effects of ointments with antibiotic for wounds

Prolonged use or non-compliance with medical recommendations on the use of the drug may provoke unwanted symptoms. Side effects of ointments with antibiotic for wounds are manifested in the form of allergic reactions at the site of application:

• Burning
• Itching
• Hyperemia
• Irritation
• Increased sensitivity to ultraviolet radiation (photosensitivity)
• Contact dermatitis
• Intoxication

To eliminate these symptoms, it is necessary to reduce the frequency of application of the product to the skin or stop treatment altogether. It is always necessary to seek medical help.

Overdose of ointments with antibiotic for wounds

Elevated doses of any drug cause adverse symptoms. Overdose of ointments with antibiotic for wounds manifests itself in the form of local allergic reactions. This symptom is similar to adverse reactions. Most often, patients experience itching, burning, redness and pain in the place of use.

To eliminate symptoms of overdose, it is recommended to stop treatment and seek medical help. The doctor will adjust the dosage or prescribe another drug.

Interactions with other drugs

Complex treatment is indicated for effective treatment of wounds. This involves the simultaneous use of multiple medications. Interactions with other drugs are prescribed by a doctor. Focusing on the stage of wound injury and the nature of the pathological process, the doctor selects different in form of release and action drugs. This will avoid side effects and symptoms of an overdose.

Very often antibacterial ointments are combined with oral antibiotics, immunostimulating agents and vitamins. If there is pus in the wound, then special ointments, most often on a plant basis, are used for drawing it. To accelerate the restoration of tissues, wound healing preparations are prescribed. The main condition for interaction with other drugs is compliance with the time interval and the absence of contraindications.

Storage conditions

In order for the drug to maintain its pharmacological properties during the entire shelf life, it is very important to observe the storage conditions. Ointment should be in the original packaging, protected from sunlight, moisture and inaccessible to children. The recommended temperature is 15-25 ° C.

Frequent temperature changes and light, negatively affect the quality of the drug. Thus, an increase in temperature reduces the activity of antibiotics. In addition, delamination and loss of homogeneity of the ointment base are possible.

Shelf life

An ointment with an antibiotic for wounds, like any other medicine, has a shelf life. As a rule, antibacterial drugs are allowed for use within 24-36 months from the date of manufacture. At the end of this period, the tube with the medicine must be disposed of. The use of overdue drugs in wound areas can provoke complications and cause pathological symptoms requiring medical attention.

Effective ointments with antibiotics for purulent wounds

1. Levosin

Antibacterial, local anesthetic. The active substances are chloramphenicol, methyluracil, sulfadimethoxin, trimecaine. The combined composition has an antimicrobial, analgesic, regenerative, necrolytic and anti-inflammatory effect. There is activity against anaerobes, gram-positive and gram-negative microorganisms.

After application on the skin quickly penetrates into the tissues, transporting the active components. Due to the hydration properties within 2-3 days, eliminates perifocal edema, cleans the wound, accelerates its healing and stimulates cellular defense factors. Does not cumulate and does not have a locally irritating effect.

• Indications for use: purulent wounds with infected mixed microflora, burns, hard-healing ulcers. It is not used for intolerance of active components, during pregnancy. Side effects are manifested in the form of skin allergic reactions.
• The drug is applied to sterile gauze gauzes, and they fill the wound with them. The drug can be injected into the purulent cavity with a catheter, syringe or drainage tube. If the wounds are not deep, then the ointment is applied a thin layer on the damaged areas and covered with a bandage. Dressings should be done daily, until the wound is completely cleansed of pus.

2. Levosin

Antimicrobial, anti-inflammatory with analgesic properties. Active components: sulfadimethoxin, methyluracil, polyethylene oxide and trimecaine. It is prescribed for the treatment of purulent wounds in the first phase of the wound process. Contraindicated to use with individual intolerance of active substances.

Before applying the medicine on the skin, it is recommended to determine the sensitivity of the microflora that caused the pathological process to it. The agent is applied directly to the skin and under the dressings, soaked gauze wipes and fill the wound with them. The dressings are done daily until the wound is completely cleansed.

3. Dioxin (dioxidine)

Antibacterial pharmacological agent, a derivative of quinoxaline. Has a wide spectrum of action, is active against many harmful microorganisms.

Does not have a local irritant effect, but can cause drug resistance of bacteria.

• Indications for use: wounds with deep purulent cavities, pustular skin diseases, wound and burn infection of various localization and complexity, long-term healing wounds and trophic ulcers.
• The medicine is applied a thin layer on the skin cleansed from purulent-necrotic masses, you can use napkins with ointment or bandages. Deep wounds pamp. Duration of therapy is 14-20 days. It is not prescribed for treatment of pregnant and newborns.
• Contraindicated apply when hypersensitivity to active substances. Adverse reactions manifest themselves as skin irritations and allergies.

For the treatment of suppuration, multicomponent ointments are widely used. Such drugs have an anti-inflammatory effect, improve local blood circulation and stimulate the restoration of skin: Oxycyclozole, Oxysone, Balsamic liniment according to Vishnevsky, Mafenite acetate, Levomethoxin. Special attention should be paid to topical preparations for drawing pus: Ichthyol, Synthomycin, Streptocide Ointment, Levomekol.

[24], [25], [26],