Nolicin for cystitis

Cystitis is a very unpleasant disease, which is accompanied by pain, burning, irritation, painful urination. The peculiarity of the disease is that it occurs suddenly, in the form of attacks, and is accompanied by severe pain. It requires immediate emergency care. Then you must call an ambulance. It is recommended to hospitalize the patient for further treatment. There are many methods and means of treatment. As practice shows, one of the most effective means of pain relief is nolitsin for cystitis.

Indications Nolicin for cystitis

Nolitsin is recommended for use in various forms of cystitis, including cystitis of bacterial etiology. It is also prescribed for other bacterial diseases of the gastrointestinal tract and genitourinary system. Almost all types of genitourinary infections require the use of Nolitsin. Even some sexually transmitted infections, including uncomplicated gonorrhea, trichomoniasis, chlamydia, can be an indication for use. In some cases, it is used to treat and prevent salmonellosis, brucellosis, various intestinal infections, and traveler's diarrhea.

The drug is prescribed for staphylococcal infections, including those with methylin-sensitive strains of microorganisms. It is used to treat escherichiosis, citrobacter, yerisiniosis, enterobacteriosis, proteus, various types of protozoa, hemophilic infections, and legionellosis.

Nolitsin is active against clostridia, petococci, and cholera. It is an effective treatment and prevention agent for purulent-septic, inflammatory diseases, bacteremia, and sepsis.

Nolitsin for chronic cystitis

Nolicin is an antibiotic belonging to the second-generation fluoroquinolone group. The main active ingredient is norfloxacin. The principle of action is that it creates bactericidal concentrations of the substance in the gastrointestinal tract, as well as in the genitourinary tract.

The drug is prescribed for chronic cystitis of bacterial etiology. Thus, it exhibits high activity against such groups of microorganisms as gonococci, cholera, Escherichia, Haemophilus influenzae, Shigella, Citrobacter, Campylobacter, and Meningococci.

It is not advisable to use Nolitsin in the treatment of cystitis caused by ureaplasmas, bacteroids, peptococci, fusobacteria, treponemas and clostridia, since the antibiotic is resistant to these microorganisms.

The mechanism of action is based on the bactericidal effect, which is achieved by binding to DNA gyrase. As a result, the process of inhibition of bacterial deoxyribonucleic acid occurs. This leads to supercoiling of the bacterial DNA chain, followed by its further destabilization. Subsequently, DNA disintegrates into smaller fragments.

Method of administration – oral. The therapeutic effect can be achieved in the shortest possible time. The main absorption and accumulation occurs in the genitourinary and gastrointestinal systems. Complete absorption occurs within 60 to 90 minutes. In order to minimize the risk of side effects, it is necessary to drink plenty of water, in particular, you need to drink at least 2 liters per day.

The antibiotic is eliminated from the body mainly with urine. Therefore, people who suffer from kidney and liver diseases should be careful when treating it, since these organs experience the maximum load on the body. Also, a small dose of the drug is excreted from the body with feces.

The antibiotic has a specific structure, special mechanisms of activity, as a result of which it exhibits high activity against bacteria that are resistant to norfloxacin. The use of nolitsin is associated with the risk of developing a cross-reaction of resistance to fluoroquinolone drugs. Resistance is due to the presence of a mutation in the bacterial genome, in particular, in the coding of DNA gyrase. In addition to the mutation effect, during antibiotic treatment, the permeability of the bacterial cell wall changes, which changes their sensitivity to the antibiotic.

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Nolitsin for cystitis with blood

If cystitis is accompanied by blood, this is a negative sign indicating that a severe complication of cystitis is developing. Most often, this is an inflammatory process, which is accompanied by an intense inflammatory process, damage to the tissue of the ureters and kidneys. The activity of tissues and cells is also significantly transformed, the permeability of the circulatory system and vessels changes. With increased permeability of blood vessels, profuse bleeding occurs. This is dangerous due to further progression of the inflammatory process, as well as the ability to develop further edema, necrosis.

In case of cystitis with blood, self-medication is not recommended, since the risk of complications is extremely high. These may be various complications, up to severe complications from the kidneys and urinary tract. Complications may progress, up to the development of severe renal and hepatic failure. Therefore, the first thing to do is to consult a doctor for qualified medical help. Prescriptions can only be made based on the results of a clinical study, examination, and the results of laboratory and instrumental studies.

One of the drugs of choice for cystitis with blood is nolitsin, but it cannot be used independently, so in this case it is inappropriate to discuss the optimal course of treatment and dosage. In each individual case, the treatment regimen will be strictly individual.

Nolitsin for acute cystitis

It is effective in acute cystitis. But you cannot prescribe it to yourself without first consulting a doctor. This is because a doctor also does not prescribe this drug on his own. This is a fairly complex drug, the basis for prescribing which is the result of a laboratory study, in particular, a bacteriological culture.

Along with bacteriological culture, a drug sensitivity test is performed. Thus, during this test, the sensitivity of microflora to the drug is determined, the optimal dosage is determined, which will have the necessary effect on the body. In accordance with the results of the test, the optimal dosage, concentration of the drug is prescribed, the scheme and duration of treatment are selected.

It is necessary to take into account that the use of Nolitsin requires adherence to a certain diet. In particular, the use of alcohol together with Nolitsin is strictly contraindicated, since in combination these substances cause the formation of complex toxic complexes, the removal of which from the body is difficult.

Also, when prescribing, it is necessary to take into account the sensitivity of other bacteria, as well as cross-reactions. Many bacteria exhibit high resistance to this antibiotic. It also has numerous contraindications. In each individual case, the choice of the scheme is adjusted in accordance with the contraindications, the current condition of the patient. Traditionally, the course of treatment is presented for a duration of 4 days. In this case, they take one tablet at an interval of 11 hours. Depending on the individual characteristics and specifics of the course of the disease in each individual case, the treatment scheme is adjusted. But the basis from which they start when creating various treatment options is precisely this standard scheme.

Release form

The drug is released in the form of tablets. Which contain 400 mg of the active substance - norfloxacin. The tablets are round, coated. The package usually contains 20 tablets.

Nolitsin tablets for cystitis

Nolitsin is used for various forms of cystitis, including acute and chronic. Cystitis can be of any etiology. Nolitsin exhibits the highest degree of activity in relation to staphylococcal and streptococcal forms of infection. It helps relieve inflammatory processes, normalize metabolic processes, and restore damaged tissues.

Taken orally before meals. The treatment regimen for each patient is strictly individual and should be based on the results of laboratory and instrumental studies. Self-medication in this case is strictly prohibited, since you can get numerous complications, such as increased inflammation, allergic reaction, necrosis of inflamed tissues, development of increased permeability of blood vessels and tissues, disruption of lymph exchange between tissues and cells.

It is known that the drug has a pronounced bacteriostatic effect, therefore it can be accompanied by the development of the inflammatory process, its progression, the development of dysbacteriosis. All this can only increase inflammation, provoke tissue necrosis. The most dangerous complication is the development of liver and kidney failure, which can progress to complete failure of the kidneys. All this suggests that self-medication is still not worthwhile, but it is advisable to consult a doctor who will select the optimal treatment regimen and monitor the treatment process.

During treatment, it is necessary to monitor the effectiveness of treatment. For this, it is necessary to periodically do the recommended laboratory and instrumental studies, which will show whether there is a need for an intermediate correction of the current treatment regimen.

In the most general form, a standard treatment regimen is used. Thus, the drug should be taken one tablet once every 11 hours, approximately 1.5-2 hours before meals. During treatment, you need to drink a lot (clean water) to reduce the load on the kidneys and ensure timely removal of metabolites.

Pharmacodynamics

The drug's action is based on the active substance - norfloxacin. This is an antibacterial agent (antibiotic), which exhibits high antibiotic activity against many gram-positive, gram-negative microorganisms, and sometimes against fungal infections, in particular, Candida fungi. Nolitsin is also active against such microorganisms as mycoplasma, ureaplasma, chlamydia, gardnerella, and other forms of microorganisms that are difficult to treat.

It is also worth noting the drug's activity against various forms of intestinal infection. It also has an effect on various forms of mixed infection (that is, mixed forms of infection that form associations that include various groups of microorganisms that form stable connections between themselves).

The drug is one of the few that acts against biofilms - stable microbiological formations that combine various microorganisms, possibly fungi, forming a single habitat. They form a single matrix, form stable connections between themselves. In biofilms, the properties of each microorganism change. First of all, they are formations that increase the resistance of microorganisms to the action of antibiotic drugs. Difficulties arise in the penetration of the drug into the matrix. It is also worth noting that resistance is acquired faster in biofilms. Thus, if one of the microorganisms has acquired resistance, the others will immediately become resistant, since there is a close relationship between them, and optimal conditions are formed for the formation of cross-reactions in the matrix.

The uniqueness of this drug is that it is active against such resistant forms of microorganisms as dysentery, Pseudomonas aeruginosa, and gonococci. It is also active against methylene-sensitive (resistant) forms of staphylococcus. It is active even against hospital strains, which are quite difficult to treat because they have a high degree of resistance. The danger is that they can also have multiple resistance. It is also active against asinetobacter, resistant forms of enterococci. However, it does not show activity against anaerobic forms of microorganisms.

Refers to antibiotic drugs, fluoroquinolone group. The principle of action is that the active substance suppresses enzymatic activity in the bacterial cell, in particular, the activity of DNA gyrase, which is responsible for DNA supercoiling, is inhibited. As a result, the main cellular processes are blocked, which leads to the impossibility of cellular reproduction, and the subsequent death of the microorganism.

A distinctive feature of nolitsin and other drugs of the fluoroquinolone group is their resistance to the effects of beta-lactamases, which are a special type of enzyme that can be produced by bacterial cells during development. It is these enzymes that often inactivate the action of the antibiotic, which leads to the development of resistance.

Pharmacokinetics

Nolitsin is a drug belonging to the group of fluoroquinolones, which is taken 1-2 times a day, while drinking plenty of water. You cannot eat at the same time, since there is an active absorption of nutrients, and the absorption of the active substance of the drug is reduced. This significantly reduces the activity of the drug.

The level of drug metabolization is low. The main absorption of the drug occurs in the intestine. Thus, up to 30-40% of the drug is absorbed in the intestine. At the same time, only 15% of the drug binds to blood plasma. Everything that is not absorbed and does not bind is gradually excreted from the body. The main percentage of the undigested substance is excreted with bile, urine, and also through the intestine. When excreted with bile, the substance again enters the intestine, as a result of which re-absorption occurs, and the substance again enters the blood, the cycle of metabolization is repeated.

The drug molecules bind to blood plasma and to each other. The bound molecules are distributed throughout the abdominal organs. The main accumulation of the substance occurs in the kidneys and urogenital tract organs. Therefore, nolitsin has the ability to penetrate the blood-brain barrier. The drug also has the ability to bind to inflamed tissue, resulting in recovery and removal of the inflammatory process (through the synthesis of anti-inflammatory factors, histamine).

The maximum concentration of the antibiotic in the blood is achieved in the blood plasma within 1-2 hours after taking the antibiotic orally. The effective action of the dose used lasts for about 12 hours. During the day, the main part of the drug is excreted from the body. In this case, the main part accumulates in the parenchymatous organs, in particular, in the ovaries, uterus, prostate, and bladder. To maintain the optimal therapeutic dosage of the drug in the blood, it is necessary to take the drug every 12 hours. If this regimen is violated, the dosage of the drug in the blood is significantly reduced, which leads to a decrease in the activity of the active substance.

Dosing and administration

Nolitsin is taken orally at 400 mg every 11 hours. The course of treatment varies widely - from 5 days to 3 months, depending on the severity of the disease, the form of cystitis, and possible complications.

• How and how much to take Nolitsin for cystitis?

Cystitis with Nolitsin should be treated only under the strict supervision of a specialist. Periodically, control laboratory and instrumental studies should be carried out. Take one tablet orally twice a day, before meals. It is important to follow the mandatory condition of treatment - drink plenty of water. Also, when treating with Nolitsin, a number of mandatory rules should be followed.

First of all, you need to monitor the amount of liquid you drink during the day. This amount should not be less than 2 liters. As soon as you take a pill, you should also wash it down with plenty of water (about 2-3 glasses), this will minimize the risk of complications in the kidneys, and also reduce the toxic effect on the kidneys.

During treatment, it is also important to monitor daily diuresis: Thus, the required amount of urine should be excreted per day, corresponding to age norms and the treatment regimen. For monitoring, these indicators can be clarified with a doctor.

You must not overexert yourself or perform heavy physical exercise, as this will contribute to the creation of additional stress on the body. It is also important to monitor changes occurring in the body, in particular, to monitor the main indicators of the body, pain. It is important to prevent the development and progression of pain in the tendons (this is an unfavorable prognostic sign when treating with Nolitsin). If the first signs of pain in the joints appear, you should immediately stop taking the drug.

It is strictly forbidden to consume alcohol and nolitsin, as this leads to the formation of complexes that have a toxic effect on the body. You should not sunbathe, swim in open water, or overheat. You should also avoid direct sunlight on any areas, especially on the organs in the lumbar region and kidneys.

It is also not recommended to drive during the treatment period, since concentration is significantly reduced, dizziness attacks may develop, especially in a tense situation. You should not drive a vehicle at least to avoid creating emergency and potentially dangerous situations on the roads for other people. You should also not work with mechanisms that require increased attention.

The treatment regimen for different forms of the disease may be different. You need to consult a doctor and choose your own, strictly individual form of treatment, but in general it can be said that it is recommended to take 400 mg 1-2 times a day. The duration of treatment also varies widely - from 1 week to 2-3 months. The longest course of treatment is 2-3 months for the chronic form of the disease. For uncomplicated forms of the disease, the course of treatment is usually an average of a month.

Mild forms require treatment lasting up to 1-2 weeks. It is also necessary to take into account that Nolitsin can also be prescribed for prophylactic purposes. For example, it can be prescribed to patients suffering from chronic forms of cystitis during long trips. In this case, one tablet is usually prescribed twice a day. Prophylaxis is carried out some time before the trip, as well as during the trip itself. But for prophylactic purposes, the drug cannot be taken for more than 3 weeks.

The drug is also used to prevent sepsis in neutropenia, immunodeficiency, and progressive cystitis. It is recommended for prophylactic purposes for women during menopause. In order to prevent relapse of recently cured cystitis, Nolitsin should also be taken (no more than 200 mg at a time). People prone to chronic forms of cystitis and other diseases of the genitourinary system are recommended to take it for prophylactic purposes. It is prescribed to prevent cystitis in urethritis, various vaginal infections in women, against the background of dysbacteriosis and intestinal infections. In some cases, Nolitsin for cystitis can be replaced with the closest analogues.

Nolitsin for cystitis in women

Women are more susceptible to cystitis, as it is facilitated by the anatomical and physiological features of the female reproductive system and urogenital tract. This includes the proximity of the intestines and vagina to the urogenital tract, as a result of which the infection more easily penetrates the genitourinary system. Also, a shorter urogenital tract, compared to men, leads to the fact that the infection spreads more quickly along the ascending path and penetrates the ureters and kidneys.

In addition, the development of cystitis in women can be facilitated by the development of hormonal disorders, restructuring, dysfunction of various organs. They are often observed against the background of hormonal imbalance, which accompanies changes in the female reproductive system. They appear during restructuring in adolescence, during pregnancy, a few days before menstruation, with ovarian dysfunction, during menopause. Often we have to deal with senile cystitis, which develops against the background of physiological changes, hormonal imbalance, and microbiocenosis disorders.

Cystitis often appears due to age-related changes in the body, against the background of aging, various diseases (infectious, venereal, dermatological, less often - somatic, leprosy, erythema).

Cystitis can also be a consequence of hypothermia, prolonged use of certain medications, including hormonal contraceptives.

Women should be especially careful when choosing a treatment regimen with Nolitsin. It is necessary to consult a doctor for advice, since self-treatment can be fraught with serious consequences. Usually, the dosage of the drug for women is almost the same as for men. Sometimes the regimen may change depending on the physiological state of the body. Thus, during menstruation, it is advisable to reduce the dosage of the drug. The drug is not recommended for use during pregnancy.

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Application for children

This drug is quite strong and toxic, so its use is permitted only from the age of 18. In some sources, you can find information indicating the possibility of using this drug from the age of 15. However, in any case, use under the age of 15 is prohibited, since it can lead to irreversible consequences, putting a powerful strain on the kidneys and liver of the child, which are not yet fully formed.

Use Nolicin for cystitis during pregnancy

During pregnancy, it is prohibited to take Nolitsin, since it is a rather strong and toxic drug that has the ability to penetrate the transplacental barrier. It poses a threat to the normal development of the fetus, and is sometimes life-threatening.

Contraindications

The drug is quite potent, belongs to the new generation of antibiotics, therefore it has a number of contraindications. All of them can be conditionally divided into relative contraindications, which suggest the presence of various options that will allow the drug to be prescribed in compliance with certain conditions and forms of use. Absolute contraindications are also distinguished, which imply that the drug cannot be used under any circumstances.

Thus, Nolitsin is absolutely contraindicated in case of pregnancy, and during breastfeeding, and for children under 18 years of age. It should also not be prescribed in cases of individual intolerance to fluoroquinolones and other components of the drug. The drug is also absolutely contraindicated in case of congenital deficiency of the enzyme glucose-6-phosphate dehydrogenase (since the risk of developing anemia increases sharply). It is completely contraindicated in epilepsy, atherosclerosis, liver and kidney failure.

Relative contraindications include porphyria, inflammatory processes in the joints and ligaments, tendon ruptures. Also, the drug should be prescribed with caution to patients with various kidney and liver diseases, since it is metabolized with urine and bile, and this significantly increases the load on the liver and kidneys. Also, the drug should not be prescribed for arrhythmia, bradycardia, tachycardia, and other heart rhythm disorders. Malignant tumors, especially myasthenia, are also a relative contraindication to taking nolitsin.

Should be taken with caution by patients who have decreased potassium levels in the blood (hypokalemia), as well as during therapy with certain antipsychotic drugs and antidepressants.

Side effects Nolicin for cystitis

Various side effects and complications may occur while taking Nolitsin. They may affect various organs and systems. Most often, gastrointestinal disorders are observed: nausea, diarrhea, vomiting, a taste of bile in the mouth, and loss of appetite. Various pathologies of the urinary system may also be observed, such as kidney inflammation, excessive urination. Blood may appear in the urine, pain when urinating. Analysis may show protein in the urine, the excretion of salts in the urine, and an increase in the level of creatinine in the urine.

From the cardiovascular system, creatinine in the blood, arrhythmia, increased heart rate, vasculitis are often observed. Headaches and tinnitus are also often encountered. Many patients note increased irritability, depression, excessive fatigue, and insomnia while taking this drug. The condition can progress to loss of consciousness, fainting, and constant dizziness. Leukopenia is recorded in clinical tests against the background of an increased number of eosinophils. Side effects in the form of various types of allergies may also be observed. With prolonged use, the development of a fungal infection (candidiasis) may be observed.

Also, one of the side effects is the impact on joints and tendons. Under the influence of nolitsin, their inflammation occurs. Also, they often lose elasticity, become fragile, easily torn, are subject to inflammation, transformation. Therefore, nolitsin cannot be taken by professional athletes, as well as those who play sports, have increased physical activity. It also significantly reduces concentration.

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Overdose

In case of overdose, the main signs of poisoning are: headache, dizziness, nausea, vomiting, digestive disorders, pain in the epigastric region, clouding of consciousness, sometimes loss of consciousness. The victim of an overdose should be given emergency assistance as soon as possible and an ambulance should be called. At the first signs of poisoning, vomiting should be induced, which will clear the gastrointestinal tract and prevent further absorption of the drug. Then the doctor will provide the necessary assistance and suggest hospitalization.

Usually, in a hospital setting, gastric lavage, neutralization of the poison, and further restorative treatment are performed. Do not forget to tell the doctor that you took Nolitsin for cystitis, and it caused the poisoning. This will significantly speed up the diagnosis and selection of the correct treatment.

Interactions with other drugs

Firstly, the drug should not be combined with alcohol. This is due to the fact that nolitsin quickly forms fairly stable complexes with alcohol, which enter the blood. It is quite difficult to remove them, they are practically not amenable to neutralization. It is also known that nolitsin and alcohol complexes are highly toxic. Also, when interacting with other drugs, especially those containing ethanol, weakness and decreased performance may occur. Sometimes allergic reactions can occur, including anaphylactic shock.

Heartburn medications and dairy products should not be taken together with Nolitsin, as this significantly reduces its activity and reduces absorption. The drug is also incompatible with antidiabetic drugs, in particular, with sulfonylurea-based drugs, theophylline. Nolitsin is also contraindicated in combination with nitrofurans.

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Storage conditions

The drug is stored for no more than two years unopened, in the original packaging at room temperature. The production date must be indicated on the packaging.

Shelf life

The drug is valid for 2 years from the date of production indicated on the package. And in an unsealed form, without the factory packaging, the drug can be stored for no more than three months.

Reviews

If you analyze the reviews, you can see that most patients note that Nolitsin is very effective in treating cystitis and other diseases of the genitourinary system. This treatment has its own disadvantages and advantages. Thus, the advantage is that the drug makes it possible to get rid of the disease completely, even from residual effects. The risk of relapse is reduced to a minimum. In addition to the main effect, it often has an additional effect on other organs and systems, in particular, it has a mild anti-inflammatory effect, and also affects mycobacteria, chlamydia, and reckettsia.

The disadvantages include the fact that the drug is quite effective in eliminating any infection. But at the same time, the normal state of the microflora may be disrupted, resulting in dysbacteriosis, and the amount of normal microflora decreases. This entails the development of a fungal infection, in particular. Candidiasis. Therefore, it is often necessary to use Nolitsin together with antifungal drugs.

Sometimes nolitsin stimulates the immune system, thereby increasing the body's ability to resist infection. When taking nolitsin, a person recovers much faster. It is also worth noting that while taking nolitsin, there are practically no complications or cases of relapse.

The disadvantage is that Nolitsin is prohibited for children with cystitis. It can only be prescribed from the age of 18, according to some sources - from the age of 15. It is also strictly prohibited for pregnant and nursing mothers.