Neyrorubin

Neurorubin is a medical drug that contains a vitamin complex - among its components, B-vitamins that have neurotropic properties, which actively assist in the implementation of protein, fat and carbohydrate metabolism processes.

Although these vitamin compounds are included in the same subcategory of useful elements, each of them has a fairly large range of therapeutic bioactivity, aimed at different systems and functions.

Indications Neyrorubina

Tablets are used as a means of prevention in the case of conditions in which there is a lack of B-vitamins, and with it in the combined treatment of the following pathologies:

• neuritis with polyneuritis;
• neuralgia ;
• poisoning (also having an alcoholic nature);
• diabetic form of polyneuropathy.

Injection fluid is used as a monotherapeutic substance, and in addition it is used in the combined treatment for the following diseases:

• polyneuropathy having a diabetic nature;
• gipovitaminosis;
• avitaminosis B1 (does not matter, in a dry or wet form);
• neuritis (can be both chronic and acute stage of pathology);
• polyneuritis and neuralgia.

[1], [2], [3]

Release form

The release of the pharmaceutical component is produced in tablets - 10 pieces inside the cell plate. Inside the box are 2 such records.

The liquid is sold in ampoules having a capacity of 3 ml - 5 ampoules inside the pack.

Pharmacodynamics

Vitamin drug complex contains elements such as pyridoxine, cyanocobalamin and thiamine. Each of these substances is required to perform a variety of processes occurring within the human body.

For example, thiamine is an active participant in the performance of metabolic processes associated with fats and carbohydrates (but not proteins). A lack of thiamine leads to an increase in lactate and pyruvic acid. This beneficial compound contributes to the deamination and transamination of essential amino acids for the body.

Thanks to these processes involving thiamine, stabilization of protein metabolism is carried out. It is necessary to take into account that the element catalyzes fat metabolism and the processes of formation of fatty acids, and in addition it stimulates the excretory activity of the intestine together with motility; In addition, the vitamin interacts with the cell walls inside the neurons and stimulates the activity of ion channels.

Pyridoxine, like thiamine, is actively involved in the conduct of fat and protein metabolism, and at the same time binds enzymes. This component is a coenzyme in the development of enzyme reactions. Vitamin helps to form the myelin neural wall and is involved in the metabolism of lipids with proteins, and besides in the binding of hemoglobin and neurotransmitters within the CNS synapses, as well as PNS.

Cyanocobalamin is extremely important in the metabolism of proteins, and with it regulates the production of purines with nucleic acids and amino acids. This vitamin is necessary for the body, because it affects the production of acetylcholine, and in addition to the processes of neural myelination. Also, this component has a positive effect on the recovery of nerve fibers and stimulates the development of impulses within peripheral NS.

Vitamin has a hematopoietic effect, regulates cholesterol levels and at the same time stimulates erythropoiesis. Cyanocobalamin helps to improve blood-forming processes and stabilizes blood-clotting speed.

In combination, all the above-mentioned vitamins help stabilize the function of the human NS and at the same time have a positive effect on the metabolism of lipids with proteins, carbohydrates and fats.

It is necessary to take into account the fact that such a vitamin complex significantly reduces pain resulting from having a diverse etiology of neurological pathologies.

[4], [5]

Pharmacokinetics

When using drugs, absorption of thiamine takes place inside the duodenum and small intestine, as well as the intestine. A small part of this vitamin is absorbed by the liver, after which the component is exchanged and decomposed, forming pyramine with thiamine carboxylic acid. The substance is excreted through the intestines and kidneys - in an unchanged state, as well as in the form of metabolic elements.

B6-vitamin hydrochloride is absorbed through the intestine, after which it undergoes intrahepatic metabolism and disintegrates, forming pyridoxamine together with pyridoxal-5-phosphate, which is a coenzyme, as well as pyridoxal (the active metabolic components of the vitamin).

Pyridoxine is closely synthesized with intraplasma blood protein. This compound accumulates inside the organs of the NA, liver and muscles. Excretion occurs through the kidneys - unchanged product and active metabolic elements.

In the case of normal absorption of cyanocobalamin, this component is exchanged and transformed into the element adenosylcobalamin. Vitamin excreted in the bile and urine, and at the same time accumulates inside the liver.

[6], [7]

Dosing and administration

The size of the medicinal portions and the duration of the treatment cycle are selected by a medical specialist, taking into account the nature of the pathology and the patient's condition. It is required to use tablets before meal or together with it; the substance is not chewed, washed down with plain water (boiled).

On average, 1-2 tablets of a drug are usually consumed per day. The whole treatment cycle on average often lasts 1 month.

Injections of injection fluid are performed to relieve pain - every day or every other day by the first injection (taking into account the severity of the pathology). The drug is injected in the / m method - inside the gluteal muscles. After improving the patient's condition, in order to maintain the therapeutic effect of the drug, 3 ml of the substance is administered 2 times a week intramuscularly.

[9]

Use Neyrorubina during pregnancy

Because there is no information regarding the safety of using drugs during lactation or pregnancy, it cannot be prescribed during these periods. But the attending doctor can prescribe vitamins to pregnant women - with a strong medical need and only provided that their benefits are significantly higher than the risk of harm.

If you need to use Neyrorubin when breastfeeding, you should cancel HB - this is due to the fact that the drug passes through the hemato-placental barrier, changing the composition of mother's milk, which can adversely affect the condition of the infant.

Contraindications

The main contraindications:

• allergic diathesis;
• the presence of severe intolerance associated with the chemical elements of the drug.

The medication can complicate the course of psoriasis, and in addition aggravate the severity of acne.

Side effects Neyrorubina

Among the main adverse events:

• nausea, increased blood transaminases of the liver, vomiting and bleeding in the stomach;
• senseless anxiety, headaches, increased irritability, anxiety, neuropathy of a sensory nature, and dizziness;
• circulatory collapse and tachycardia;
• itching, urticaria, pulmonary swelling, the appearance of acne or rash on the epidermis, cyanosis, hyperhidrosis, anaphylaxis and angioedema.

[8]

Overdose

Often, when a patient is intoxicated, an exacerbation of negative symptoms of drugs occurs.

With such violations, it is recommended to conduct gastric lavage, and then carry out the appropriate symptomatic measures.

[10], [11], [12], [13]

Interactions with other drugs

It is forbidden to combine the drug with altretamin or levodopa, because it weakens the drug activity of these drugs.

To avoid potentiation of the toxic properties of isoniazid, one should abandon the combination of the vitamin complex and this drug.

It must be borne in mind that thiosemicarbazone and fluorouracil have an antagonistic effect on thiamine.

The absorption of the drug is weakened when combined with substances that demonstrate antacid activity and have an enveloping effect.

[14], [15]

Storage conditions

Neurorubin is required to keep in a closed place from small children. Temperature indicators - within the mark of 25 ° C.

Shelf life

Neurorubin can be used for a 4-year period from the time of sale of the drug.

Application for children

Neurubin should not be used in pediatrics (persons under 18 years of age).

Analogs

Analogues of drugs are Vitaxone, Neurobex, Neuromultivitis with Neurobion, and in addition, Unigamma, Neurovitan and Nerviplex.