Neurorubin

Neurorubin is a medicinal product that contains a vitamin complex - among its components are B-vitamins with neurotropic properties, which actively help in the processes of protein, fat and carbohydrate metabolism.

Although these vitamin compounds belong to the same subcategory of beneficial elements, each of them has a fairly wide range of therapeutic bioactivity aimed at different systems and functions.

Indications Neurorubin

The tablets are used as a preventive measure in cases of conditions in which there is a deficiency of B-vitamins, and also in the combined treatment of the following pathologies:

• neuritis with polyneuritis;
• neuralgia;
• poisoning (also of an alcoholic nature);
• diabetic form of polyneuropathy.

The injection liquid is used as a monotherapeutic substance, and in addition, it is also used in combination therapy for the following diseases:

• polyneuropathy of diabetic origin;
• hypovitaminosis;
• avitaminosis B1 (it does not matter whether in dry or wet form);
• neuritis (there may be both chronic and acute stages of the pathology);
• polyneuritis and neuralgia.

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Release form

The pharmaceutical component is released in tablets - 10 pieces inside a cell plate. Inside the box - 2 such plates.

The liquid is sold in ampoules with a capacity of 3 ml - 5 ampoules inside a pack.

Pharmacodynamics

The vitamin medicinal complex contains such elements as pyridoxine, cyanocobalamin and thiamine. Each of these substances is required to perform various processes occurring inside the human body.

For example, thiamine is an active participant in the implementation of metabolic processes associated with fats and carbohydrates (but not proteins). Deficiency of thiamine leads to an increase in lactate and pyruvic acid values. This useful compound promotes deamination, as well as transamination of amino acids important for the body.

Thanks to these processes, which occur with the participation of thiamine, the stabilization of protein metabolism is carried out. It is necessary to take into account that the element catalyzes fat metabolism and the processes of formation of fatty acids, and in addition, it stimulates the excretory activity of the intestine together with peristalsis; in addition, the vitamin interacts with the cell walls inside neurons and stimulates the activity of ion channels.

Pyridoxine, like thiamine, is actively involved in the conduct of fat and protein metabolism, and at the same time binds enzymes. This component is a coenzyme in the development of enzymatic reactions. The vitamin helps to form the myelin neuronal wall and is involved in the exchange of lipids with proteins, and in addition, in the binding of hemoglobin and neurotransmitters inside the synapses of the central nervous system, as well as the peripheral nervous system.

Cyanocobalamin is extremely important in protein metabolism, and at the same time regulates the production of purines with nucleic acids and amino acids. This vitamin is necessary for the body because it affects the production of acetylcholine, and in addition, the processes of neuronal myelination. This component also has a positive effect on the restoration of nerve fibers and stimulates the development of impulses within the peripheral NS.

The vitamin has a hematopoietic effect, regulates cholesterol levels and at the same time stimulates erythropoiesis processes. Cyanocobalamin helps improve hematopoiesis processes and stabilizes the rate of blood clotting.

In combination, all of the above vitamins help to stabilize the function of the human nervous system and at the same time have a positive effect on the metabolism of lipids with proteins, carbohydrates and fats.

It is also necessary to take into account that such a vitamin complex significantly reduces pain arising from neurological pathologies of various etiologies.

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Pharmacokinetics

When using drugs, thiamine is absorbed inside the duodenum and small intestine, as well as the intestine. A small part of this vitamin is absorbed by the liver, after which the component undergoes metabolism and disintegrates, forming pyramine with thiamine carboxylic acid. The substance is excreted through the intestines and kidneys - in an unchanged state, as well as in the form of metabolic elements.

Vitamin B6 hydrochloride is absorbed through the intestines, after which it undergoes intrahepatic metabolism and breaks down, forming pyridoxamine together with pyridoxal-5-phosphate, which is a coenzyme, as well as with pyridoxal (the active metabolic components of the vitamin).

Pyridoxine is closely synthesized with intraplasmic blood protein. This compound accumulates inside the organs of the nervous system, liver and muscles. Excretion occurs through the kidneys - unchanged product and active metabolic elements.

In case of normal absorption of cyanocobalamin, this component undergoes exchange and is transformed into the element adenosylcobalamin. The vitamin is excreted with bile and urine, and at the same time accumulates in the liver.

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Dosing and administration

The size of the medicinal portions and the duration of the treatment cycle are selected by a medical specialist, taking into account the nature of the pathology and the patient's condition. Tablets must be taken before or with food; the substance is not chewed, washed down with plain water (boiled).

On average, 1-2 tablets of the drug are usually taken per day. The entire treatment cycle often lasts on average 1 month.

Injections of the injection liquid are performed to relieve pain - daily or every other day, 1 injection (taking into account the severity of the pathology). The drug is administered intramuscularly - into the gluteal muscles. After the patient's condition improves, in order to maintain the therapeutic effect of the drug, 3 ml of the substance is administered intramuscularly 2 times a week.

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Use Neurorubin during pregnancy

Since there is no information regarding the safety of using the drug during lactation or pregnancy, it cannot be prescribed during these periods. But the attending physician can prescribe vitamins to pregnant women - if there is a strong medical need and only if the benefit from them is significantly higher than the risk of causing harm.

If it is necessary to use Neurorubin during breastfeeding, breastfeeding should be discontinued - this is due to the fact that the medication passes through the hematoplacental barrier, changing the composition of breast milk, which can negatively affect the condition of the baby.

Contraindications

Main contraindications:

• diathesis of allergic origin;
• the presence of severe intolerance associated with the chemical elements of the drug.

The medication can complicate the course of psoriasis, and also worsen the severity of acne.

Side effects Neurorubin

Among the main side effects are:

• nausea, increased blood levels of liver transaminases, vomiting and bleeding in the stomach area;
• unexplained feelings of restlessness, headaches, increased irritability, a feeling of anxiety, sensory neuropathy, and dizziness;
• circulatory collapse and tachycardia;
• itching, urticaria, pulmonary edema, acne or rashes on the epidermis, cyanosis, hyperhidrosis, anaphylaxis and Quincke's edema.

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Overdose

Often, when intoxicated, the patient experiences an exacerbation of negative symptoms of the drug.

In such cases, it is recommended to perform gastric lavage and then carry out appropriate symptomatic measures.

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Interactions with other drugs

It is prohibited to combine the drug with altretamine or levodopa, because it weakens the medicinal activity of these drugs.

To avoid potentiating the toxic properties of isoniazid, one should avoid combining the vitamin complex and this medication.

It should be taken into account that thiosemicarbazone and fluorouracil have an antagonistic effect on thiamine.

The absorption of the drug is weakened when combined with substances that exhibit antacid activity and have an enveloping effect.

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Storage conditions

Neurorubin must be stored in a place closed to small children. Temperature indicators - within the mark of 25 ° C.

Shelf life

NeuroRubin can be used for a period of 4 years from the date of sale of the drug.

Application for children

NeuroRubin should not be used in pediatrics (persons under 18 years of age).

Analogues

The analogs of the drug are Vitaxon, Neurobeks, Neuromultivit with Neurobion, and in addition to this, Unigamma, Neurovitan and Nerviplex.