Nevigramone

Nevigramon has antibacterial and bacteriostatic properties.

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Indications Nevigramon

It is used for therapy in the development of infections in the gastrointestinal tract and urinary tract caused by the activity of microbes sensitive to the effects of drugs.

Among such diseases are cystitis with cholecystitis, urethritis and pyelonephritis with prostatitis. In addition, antibacterial drugs are prescribed to prevent complications after surgical procedures.

Release form

The medicine is released in capsules, which are packed in bottles of 56 pieces. There is 1 such bottle inside the box.

Pharmacodynamics

The active element of the drug has an antibacterial effect and belongs to the category of quinolones.

The acid inhibits the processes of replication and polymerization of bacterial DNA.

The drug demonstrates effectiveness against gram-negative microbes (Shigella, Friedlander's bacillus, Proteus, Escherichia coli and Salmonella), excluding Pseudomonas aeruginosa. Taking into account the sensitivity of the bacteria to the drug effect and its level in the body, the drug can have a bactericidal or bacteriostatic effect.

Sensitivity to the drug is demonstrated by microbes and their strains that are resistant to sulfonamides and antibiotics.

The drug does not suppress the activity of gram-positive bacteria and anaerobes. In addition, resistance to it often develops.

Pharmacokinetics

After oral administration, the drug is rapidly absorbed. The bioavailability level is 95%, and synthesis with blood protein is approximately 93%. Peak values are observed after 1-2 hours from the moment of taking the capsule. It is distributed mainly within the renal tissue.

Once inside the liver cells, the drug undergoes metabolism.

The excretion of the substance is carried out by the kidneys.

Dosing and administration

The medicine is taken orally, 1 hour before meals.

The size of the dosage portions and the duration of treatment should be determined by the doctor. Usually, an adult is prescribed 8 capsules (they contain 4 g of nalidixic acid), which must be divided into 4 doses. Such treatment lasts approximately 7 days. After that, it is allowed to reduce the daily portion to 0.5 g (taking 4 capsules with the above frequency of use).

Adolescents over 12 years of age, weighing more than 40 kg, are prescribed to take 50 mg/kg of the substance 3-4 times a day.

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Use Nevigramon during pregnancy

Nevigramon should not be prescribed in the 1st trimester or during breastfeeding.

Contraindications

Main contraindications:

• shaking palsy;
• allergy to the components of the drug;
• porphyria or epilepsy;
• severe atherosclerosis of cerebral vessels;
• diseases affecting the kidneys or liver and having a severe form;
• deficiency of the G6FD element.

Side effects Nevigramon

The use of the drug may provoke the occurrence of some side effects:

• a feeling of general weakness or drowsiness, headaches and dizziness;
• visual impairment, diplopia, and distortion of color perception (symptoms disappear after the end of therapy; it is necessary to reduce the dose or stop taking the drug);
• itching or rash on the epidermis, urticaria and arthralgia;
• redness of the epidermis, photosensitivity of the skin, the appearance of rashes in the form of blisters with liquid (disappears within 14-60 days after stopping the use of the drug, but relapses may develop);
• occasionally, convulsions, toxic psychosis and an increase in intracranial pressure occur;
• stomach pain, nausea, diarrhea and vomiting;
• Occasionally, anaphylactoid and anaphylactic symptoms, angioedema, anemia, metabolic acidosis, paresthesia, and also cholestasis and thrombocytopenia appear.

A report of the development of paralysis in the region of the 6th cranial nerve has been recorded.

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Overdose

Signs of poisoning include: metabolic acidosis, nausea, convulsions, lethargy, psychosis, and increased intracranial pressure.

To eliminate disorders, supportive procedures are performed in accordance with the symptoms that appear.

Interactions with other drugs

The use of probenecid increases the likelihood of adverse effects associated with the use of the drug and also reduces its effectiveness.

Combination of Nevigramon with other antibiotics (such as chloramphenicol and tetracycline with nitrofurazolidone) weakens its therapeutic properties.

The drug can potentiate the medicinal effect of oral anticoagulants (coumarin derivatives and warfarin). Therefore, with such combinations, it is necessary to monitor the PTI values and, if necessary, reduce the daily dose of anticoagulants.

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Storage conditions

Nevigramon should be kept in a place out of reach of children and protected from sunlight. Temperature – standard.

Shelf life

Nevigramon can be used within 5 years from the date of release of the drug.

Application for children

It is prohibited to use in children under 12 years of age. The drug is used with extreme caution in adolescents over 12 years of age.

Analogues

The analogue of the drug is the drug Palin.

Reviews

Nevigramon often receives feedback from parents who have used the medicine for children as prescribed by a doctor. In general, parents are satisfied with the therapeutic effect of the drug, and also note that no side effects appear when using it.

Adults usually use the drug to treat cystitis. In these cases, Nevigramon also demonstrates high efficiency, curing the disease and at the same time eliminating the risk of relapse.