Nevigramon

Nevigramon has antibacterial and bacteriostatic properties.

[1], [2], [3], [4]

Indications Snowworm

It is used for therapy in the development of infections in the gastrointestinal tract and urethra, caused by the activity of microbes sensitive to the effect of drugs.

Among such diseases are cystitis with cholecystitis, urethritis and pyelonephritis with prostatitis. In addition, an antibacterial drug is prescribed to prevent complications after surgical procedures.

Release form

Release of the medication is made in capsules, which are packed in flakonchiki, 56 pieces each. Inside the box there is one such bottle.

Pharmacodynamics

The active element of the preparation has an antibacterial effect and is included in the category of quinolones.

Acid inhibits the replication and polymerization of bacterial DNA.

The medication demonstrates effectiveness against gram-negative microbes (Shigella, Friedlander's stick, Proteus, Escherichia coli and Salmonella), excluding the Pseudomonas aeruginosa. Given the sensitivity of the bacteria to the drug effect and its level inside the body, the drug may have a bactericidal or bacteriostatic effect.

Sensitivity to the drug is demonstrated by microbes and their strains, which are resistant to sulfonamides with antibiotics.

The drug does not inhibit the activity of gram-positive bacteria and anaerobes. In addition, it often develops resistance.

Pharmacokinetics

After taking the medication inside, its rapid absorption occurs. The level of bioavailability is 95%, and the synthesis with blood protein is approximately 93%. Peak values are noted after 1-2 hours from the moment of taking the capsule. It is distributed mostly inside the kidney tissues.

Penetrating into the hepatic cells, the drug is metabolized.

Excretion of the substance is realized by the kidneys.

Dosing and administration

The medicine is consumed inside, 1 hour before eating.

Dimensions of dosing portions and duration of treatment should be determined by the doctor. Usually an adult is prescribed the use of 8 capsules (they contain 4 g of nalidixic acid), which need to be divided into 4 uses. Such treatment lasts about 7 days. After that, it is allowed to reduce the daily portion to 0.5 g (taking 4 capsules with the above frequency of application).

Adolescents over 12 years of age, with weight over 40 kg, are prescribed to take 50 mg / kg of substance in 3-4 daily use.

[6]

Use Snowworm during pregnancy

You can not appoint Nevigramon on the 1st trimester, and also when breastfeeding.

Contraindications

The main contraindications:

• tremor paralysis;
• allergy to the elements of the drug;
• porphyria or epilepsy;
• atherosclerosis of cerebrospinal vessels in severe degree;
• diseases affecting the kidney or liver, and having a severe form;
• lack of element G6FD.

Side effects Snowworm

The use of the drug may trigger the occurrence of some side effects:

• a feeling of general weakness or drowsiness, headaches and dizziness;
• weakening of vision, diplopia, as well as distortion of color perception (manifestations disappear after the end of therapy, you need to lower the dose or cancel the medicine);
• itching or rash on the epidermis, hives and arthralgia;
• reddening of the epidermis, photosensitivity of the skin, the appearance of rashes in the form of vesicles with fluid (disappears in the period of 14-60 days after discontinuation of drug use, but relapses may develop);
• Occasionally there are convulsions, psychosis of a toxic nature and there is an increase in the level of ICP;
• stomach pain, nausea, diarrhea and vomiting;
• occasionally there are anaphylactoid and anaphylactic signs, angioedema, anemia, metabolic acidosis, paresthesia, and in addition cholestasis and thrombocytopenia.

A report on the development of paralysis in the region of the 6th cranial nerve was recorded.

[5]

Overdose

Among the signs of poisoning: metabolic form of acidosis, nausea, convulsions, lethargic state, psychosis and an increase in ICP.

To eliminate the disorders, support procedures are performed in accordance with the emerging symptoms.

Interactions with other drugs

The use of probenecid increases the likelihood of the appearance of negative signs associated with the use of drugs, and also weakens its effectiveness.

Combining Nevigramone with other antibiotics (such as chloramphenicol and tetracycline with nitrofurazolidone) weakens its therapeutic properties.

Medication is able to potentiate the medicinal effect of anticoagulants for ingestion (coumarin derivatives and warfarin). Therefore, with such combinations it is necessary to monitor the values of PTI and, if necessary, lower the daily portion of anticoagulants.

[7], [8]

Storage conditions

The nevigramon must be kept in a place that is closed from children and protected from sunlight. Temperature is standard.

Shelf life

Nevigramon can be used within 5 years from the date of release of the drug.

Application for children

It is forbidden to use in children under 12 years of age. Extremely cautious preparation is used for adolescents over 12 years old.

Analogues

The analogue of the medicine is the medicine Palin.

Reviews

Nevigramon often receives feedback from parents who used medicine for children for medical purposes. In general, parents are satisfied with the therapeutic effect of drugs, and also note that when it is used, there are no side effects.

Adults usually use a drug to treat cystitis. In these cases Nevigramon also demonstrates high efficiency, curing the disease and at the same time eliminating the risk of relapse.