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Neurodar
Last reviewed: 23.04.2024
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Neurodar is a psychostimulant used in the development of ADHD. Included in the group of nootropic substances.
Indications Neurodar
It is used in the following conditions:
- stroke ;
- disorders of intracerebral blood flow in the acute stage, as well as complications and consequences of this violation;
- TBI, as well as its consequences of a neurological nature;
- cognitive disorders and behavioral problems associated with cerebral disorders of a degenerative and vascular chronic nature.
Release form
The release of the element is realized in the form of injection liquid - 0.5 or 1 g inside the ampoule with a capacity of 4 ml, 5 pieces inside the blister; 1 blister in a pack.
Pharmacodynamics
Citicoline helps to stimulate the biosynthesis of phospholipids that are part of the structure of the neural walls, which is determined during MRS. This principle of influence allows the substance to improve the work of some membrane mechanisms - the functioning of ion-exchange terminations and pumps, whose modulation is required for the stable conduct of neural impulses.
The normalizing effect of citicoline on neural walls leads to the development of an anti-edema effect, which helps to weaken brain edema.
Experimental tests have shown that the drug slows down the activation process of certain phospholipases (such as A1 with A2, as well as C and D), reduces the amount of free radicals that form, prevents the destruction of membrane structures and retains the activity of antioxidant protective components (glutathione).
The drug maintains the energy supply of neurons, slows apoptosis, and also stimulates the binding of acetylcholine.
Experiments have confirmed that citicoline has a prophylactic neuroprotective effect in the case of focal cerebral ischemia.
In clinical tests, it was found that the substance significantly increases the functional recovery in individuals with acute ischemia affecting cerebral blood flow, which coincides with the inhibition of the growth of ischemic brain destruction in accordance with the data from neuroimaging.
In individuals with TBI, the drug increases the recovery rate and reduces the duration and severity of post-traumatic symptoms.
The substance improves the performance of consciousness along with attention, eliminates neurological and at the same time cognitive impairment provoked by cerebral ischemia, and also helps to ease the signs of amnesia.
Pharmacokinetics
Citicoline is absorbed without complications during intravenous or intramuscular administration, and when ingested. After the use of drugs there is a significant increase in plasma indicators of choline. In the case of oral administration, the drug is almost completely absorbed. Tests have demonstrated that the level of bioavailability after parenteral and oral use is almost the same. The drug undergoes metabolic processes inside the liver along with the intestines; this forms cytidine with choline.
Citicoline used is well distributed inside the cerebral structures, at a high rate of incorporation into the choline fractions within the phospholipid structures, as well as in the cytidine fraction within the cytidine nucleotides with nucleic acids. Inside the brain, the drug integrates with the cytoplasmic, cellular, and also mitochondrial walls, integrating into the structure of the phospholipid fraction.
Only a small portion of the portion is noted inside the feces with urine (less than 3%). Approximately 12% is excreted through CO2 - with exhaled air. During excretion of the substance with urine, there are 2 stages: the first is 36 hours, during which the rate of excretion decreases rapidly; at the 2nd the excretion rate is much lower. Similar phasing is observed during excretion through the respiratory tract. At the same time, the rate of CO2 excretion first decreases rapidly (for about 15 hours), and then much slower.
Dosing and administration
Adults need to apply at 0.5-2 g of substance per day (the size of the portion depends on the intensity of the manifestations of the disease).
The drug is introduced in / in or in the / m method.
Intravenously, it is used through injection (over a 3-5-minute length, taking into account the size of the dosage) or an IV (at a rate of 40-60 drops / minute).
For the day, you can use no more than 2 g of the drug. The duration of therapy is determined by the nature of the pathology and is selected by a doctor.
The injection liquid can be used only once - it is injected immediately after opening the ampoule. The remaining substance should be disposed of. The drug is allowed to mix with any isotonic fluids for IV injection and, in addition, with hypertonic glucose fluid.
If necessary, continue therapy can be applied by applying Neurodar in the form of liquid for oral administration.
[4]
Use Neurodar during pregnancy
There is not enough information regarding the use of citicoline in pregnant women. There is also no information about the release of a substance from the mother's milk or the effect on the fetus. Because of this, during these periods, the drug is prescribed only in situations where the likely benefit to the woman is more expected than the risk of deterioration to the infant or fetus.
Contraindications
It is contraindicated to use the drug with a strong sensitivity associated with its elements, and in addition with an increased tone of the parasympathetic NA.
Side effects Neurodar
Among the adverse events:
- lesions of the PNS and CNS function: vertigo, severe headaches and hallucinations;
- disorders associated with the activity of the cardiovascular system: a decrease or increase in blood pressure or tachycardia;
- impaired respiratory function: dyspnea;
- problems with the work of the digestive system: vomiting or nausea and diarrhea;
- immune manifestations: signs of allergies, including hyperemia, angioedema, itching and rash, and also anaphylaxis, purpura and urticaria;
- systemic disorders: increased temperature, hyperhidrosis, chills, and changes in the injection zone.
[3]
Storage conditions
Neurodar is required to be kept in a place closed from small children. Temperature marks are not higher than 25 ° С.
[7],
Shelf life
Neurodar can be used for a 36-month term from the time the therapeutic agent is manufactured.
Application for children
There are only limited data regarding the use of drugs in pediatrics.
Analogs
Analogues of drugs are the drugs Difoshotsin, Cytokon, Somazina and Quanil with Neocebrone, and in addition to this Lira with Somakson and Tsitsikolin-Novo with Neuroxone. Also on the list is Cerakson with Farmakson and Tsitimaks-Darnitsa.
Attention!
To simplify the perception of information, this instruction for use of the drug "Neurodar" translated and presented in a special form on the basis of the official instructions for medical use of the drug. Before use read the annotation that came directly to medicines.
Description provided for informational purposes and is not a guide to self-healing. The need for this drug, the purpose of the treatment regimen, methods and dose of the drug is determined solely by the attending physician. Self-medication is dangerous for your health.