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Neurodar
Last reviewed: 04.07.2025
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Neurodar is a psychostimulant used in the development of ADHD. It belongs to the group of nootropic substances.
Indications Neurodara
It is used in the following conditions:
- stroke;
- disorders of intracerebral blood flow in the acute stage, as well as complications and consequences of this disorder;
- TBI and its consequences of a neurological nature;
- cognitive disorders and problems with behavioral reactions associated with chronic degenerative and vascular brain disorders.
Release form
The element is released in the form of injection liquid - 0.5 or 1 g inside an ampoule with a capacity of 4 ml, 5 pieces inside a blister; 1 blister in a pack.
Pharmacodynamics
Citicoline helps stimulate the biosynthesis of phospholipids that are part of the structure of neuronal walls, as determined by MRS. This principle of action allows the substance to improve the work of some membrane mechanisms - the functioning of ion-exchange endings and pumps, whose modulation is required for stable conduction of neuronal impulses.
The normalizing effect of citicoline on the neuronal walls leads to the development of an anti-edematous effect, which helps to reduce cerebral edema.
Experimental tests have shown that the drug slows down the activation of individual phospholipases (such as A1 with A2, as well as C and D), reduces the volume of free radicals formed, prevents the destruction of membrane structures and maintains the activity of antioxidant protective components (glutathione).
The drug preserves the energy reserves of neurons, slows down apoptosis, and also stimulates the processes of acetylcholine binding.
Experiments have confirmed that citicoline has a prophylactic neuroprotective effect in cases of focal cerebral ischemia.
Clinical tests have shown that the substance significantly increases functional recovery in individuals with acute ischemia affecting cerebral blood flow, which coincides with inhibition of the growth of ischemic brain damage volumes according to neuroimaging data.
In people with TBI, the drug increases the rate of recovery and reduces the duration and severity of post-traumatic symptoms.
The substance improves the indicators of consciousness along with attention, eliminates neurological and cognitive disorders caused by cerebral ischemia, and also helps to weaken the signs of amnesia.
Pharmacokinetics
Citicoline is absorbed without complications both during intravenous or intramuscular administration and when taken orally. After using the drug, a significant increase in plasma choline levels is noted. In the case of oral administration, the drug is almost completely absorbed. Tests have shown that the level of bioavailability after parenteral and oral use is almost the same. The drug undergoes metabolic processes in the liver together with the intestine; in this case, cytidine with choline is formed.
The applied citicoline is well distributed inside the brain structures, at high speed being included in the choline fractions inside the phospholipid structures, as well as in the cytidine fraction inside the cytidine nucleotides with nucleic acids. Inside the brain, the medicine is integrated with the cytoplasmic, cellular, and mitochondrial walls, being built into the structure of the phospholipid fraction.
Only a small part of the portion is excreted in the feces with urine (less than 3%). Approximately 12% is excreted through CO2 - with exhaled air. During excretion of the substance with urine, 2 stages are noted: the 1st is 36 hours, during which the excretion rate quickly decreases; during the 2nd, the excretion rate is much lower. Similar stages are also noted during excretion through the respiratory tract. In this case, the CO2 excretion rate first decreases quickly (over approximately 15 hours), and then much more slowly.
Dosing and administration
Adults need to take 0.5-2 g of the substance per day (the portion size depends on the intensity of the disease).
The medication is administered intravenously or intramuscularly.
It is used intravenously via injection (over a 3-5 minute period, depending on the dosage size) or via drip (at a rate of 40-60 drops/minute).
No more than 2 g of the drug can be used per day. The duration of therapy is determined by the nature of the pathology and is selected by the doctor.
The injection fluid can be used only once - it is administered immediately after opening the ampoule. The remaining substance should be disposed of. The medication can be mixed with any isotonic fluids for intravenous injections, and in addition with hypertonic glucose liquid.
If necessary, therapy can be continued using Neurodar in the form of a liquid for oral administration.
[ 4 ]
Use Neurodara during pregnancy
There is not enough information regarding the use of citicoline in pregnant women. There is also no information about the excretion of the substance in breast milk or the effect on the fetus. Because of this, during these periods, the drug is prescribed only in situations where the probable benefit to the woman is more expected than the risks of deterioration for the baby or fetus.
Contraindications
It is contraindicated to use the medication in case of strong sensitivity associated with its elements, as well as in case of increased tone of the parasympathetic nervous system.
Side effects Neurodara
Side effects include:
- damage to the functions of the PNS and CNS: vertigo, severe headaches and hallucinations;
- disorders associated with the activity of the cardiovascular system: decrease or increase in blood pressure or tachycardia;
- respiratory dysfunction: dyspnea;
- problems with the digestive system: vomiting or nausea and diarrhea;
- immune manifestations: signs of allergy, including hyperemia, Quincke's edema, itching and rashes, as well as anaphylaxis, purpura and urticaria;
- systemic disorders: increased temperature, hyperhidrosis, chills and changes in the injection area.
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Storage conditions
Neurodar must be stored in a place closed to small children. Temperature marks - no higher than 25°C.
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Shelf life
Neurodar can be used for a period of 36 months from the date of manufacture of the therapeutic agent.
Application for children
There are only limited data regarding the use of drugs in pediatrics.
Analogues
The analogs of the drug are Diphosphocin, Cytocon, Somazina and Quanil with Neocebron, and in addition to this, Lira with Somaxon and Citicoline-Novo with Neuroxon. Also on the list are Ceraxon with Farmakson and Citimax-Darnitsa.
Attention!
To simplify the perception of information, this instruction for use of the drug "Neurodar" translated and presented in a special form on the basis of the official instructions for medical use of the drug. Before use read the annotation that came directly to medicines.
Description provided for informational purposes and is not a guide to self-healing. The need for this drug, the purpose of the treatment regimen, methods and dose of the drug is determined solely by the attending physician. Self-medication is dangerous for your health.